Factors linked to severe thrombocytopenia during antiviral therapy in patients with chronic hepatitis c and pretreatment low platelet counts

BMC Gastroenterology

Volumn 12, Issue , 2012, Pages

  Lin, Kung Hung ^a   Hsu, Ping I ^a,b   Yu, Hsien Chung ^a   Lin, Chun Ku ^a   Tsai, Wei Lun ^a   Chen, Wen Chi ^a   Chan, Hoi Hung ^a   Lai, Kwok Hung ^a  

^a KAOHSIUNG VETERANS GENERAL HOSPITAL   (Taiwan)

^b TAIPEI MEDICAL UNIVERSITY   (Taiwan)

Author keywords

Hcv; Peg ifn ; Ribavirin; Thrombocytopenia

Indexed keywords

ANTIVIRUS AGENT; PEGINTERFERON ALPHA2A; PEGINTERFERON ALPHA2B; RIBAVIRIN; ALPHA INTERFERON; MACROGOL DERIVATIVE; RECOMBINANT PROTEIN;

ADULT; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANTIVIRAL THERAPY; ARTICLE; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DISEASE SEVERITY; DRUG WITHDRAWAL; FEMALE; FOLLOW UP; HEALTH CARE QUALITY; HEPATITIS C; HIGH RISK PATIENT; HUMAN; MAJOR CLINICAL STUDY; MALE; MEDICAL RECORD; PREDICTIVE VALUE; PROTHROMBIN TIME; RISK ASSESSMENT; SIDE EFFECT; SPLENOMEGALY; THROMBOCYTE COUNT; THROMBOCYTOPENIA; BLOOD; DRUG COMBINATION; HOSPITALIZATION; MIDDLE AGED; MULTIVARIATE ANALYSIS; RETROSPECTIVE STUDY; RISK FACTOR;

ADULT; ANTIVIRAL AGENTS; DRUG THERAPY, COMBINATION; FEMALE; FOLLOW-UP STUDIES; HEPATITIS C, CHRONIC; HUMANS; INTERFERON-ALPHA; MALE; MIDDLE AGED; MULTIVARIATE ANALYSIS; PLATELET COUNT; POLYETHYLENE GLYCOLS; RECOMBINANT PROTEINS; RETROSPECTIVE STUDIES; RIBAVIRIN; RISK FACTORS; SEVERITY OF ILLNESS INDEX; THROMBOCYTOPENIA;

EID: 84862815171     PISSN: None     EISSN: 1471230X     Source Type: Journal    
DOI: 10.1186/1471-230X-12-7     Document Type: Article

References (36)

1. Ghany MG, Strader DB, Thomas DB, Seeff LB, . American Association for the Study of Liver Diseases Diagnosis, management, and treatment of hepatitis C: an update. Hepatology 2009, 49:1335-1374. 10.1002/hep.22759, 19330875, American Association for the Study of Liver Diseases.
2. Fried MW, Shiffman ML, Reddy KR, Smith C, Marinos G, Gonçales FL, Häussinger D, Diago M, Carosi G, Dhumeaux D, Craxi A, Lin A, Hoffman J, Yu J. Peginterferon alfa-2a plus ribavirin for chronic hepatitis C virus infection. N Engl J Med 2002, 347:975-982. 10.1056/NEJMoa020047, 12324553.
3. Manns MP, McHutchison JG, Gordon SC, Rustgi VK, Shiffman M, Reindollar R, Goodman ZD, Koury K, Ling M, Albrecht JK. Peginterferon alfa-2b plus ribavirin compared with interferon alfa-2b plus ribavirin for initial treatment of chronic hepatitis C: a randomised trial. Lancet 2001, 358:958-965. 10.1016/S0140-6736(01)06102-5, 11583749.
4. Hadziyannis SJ, Sette H, Morgan TR, Balan V, Diago M, Marcellin P, Ramadori G, Bodenheimer H, Bernstein D, Rizzetto M, Zeuzem S, Pockros PJ, Lin A, Ackrill AM, . PEGASYS International Study Group Peginterferon-alpha2a and ribavirin combination therapy in chronic hepatitis C: a randomized study of treatment duration and ribavirin dose. Ann Intern Med 2004, 140:346-355. PEGASYS International Study Group.
5. Roomer R, Hansen BE, Janssen HLE, de Knegt RJ. Thrombocytopenia and the risk of bleeding during treatment with peginterferon alfa and ribavirin for chronic hepatitis C. J Hepatol 2010, 53:455-459. 10.1016/j.jhep.2010.04.013, 20561709.
6. McHutchison JG, Dusheiko G, Shiffman ML, Rodriguez-Torres M, Sigal S, Bourliere M, Berg T, Gordon SC, Campbell FM, Theodore D, Blackman N, Jenkins J, Afdhal NH, . TPL102357 Study Group Eltrombopag for thrombocytopenia in patients with cirrhosis associated with hepatitis C. N Engl J Med 2007, 357:2227-2236. 10.1056/NEJMoa073255, 18046027, TPL102357 Study Group.
7. Dienstag JL, McHutchison JG. American Gastroenterological Association technical review on the management of hepatitis C. Gastroenterology 2006, 130:231-264. 10.1053/j.gastro.2005.11.010, 16401486.
8. Shiffman ML, Ghany MG, Morgan TR, Wright EC, Everson GT, Lindsay KL, Lok AS, Bonkovsky HL, Di Bisceglie AM, Lee WM, Dienstag JL, Gretch DR. Impact of reducing peginterferon alfa-2a and ribavirin dose during retreatment in patients with chronic hepatitis C. Gastroenterology 2007, 132:103-112. 10.1053/j.gastro.2006.11.011, 17241864.
9. Lole KS, Jha JA, Shrotri AP, Tandon BN, Prasad VG, Arankalle VA. Comparison of hepatitis C virus genotyping by 5' noncoding region- and core- based reverse transcriptase PCR assay with sequencing and use of the assay for determining subtype distribution in India. J Clin Microbiol 2003, 41:5240-5244. 10.1128/JCM.41.11.5240-5244.2003, 262521, 14605173.
10. Bedossa P, Poynard T. An algorithm for the grading of activity in chronic hepatitis C. The METAVIR Cooperative Study Group. Hepatology 1996, 24:289-293. 10.1002/hep.510240201, 8690394.
11. Loftus WK, Metreweli C. Normal splenic size in a Chinese population. Journal of Ultrasound in Medicine 1997, 16:345-347.
12. Weksler BB. Review article: the pathophysiology of thrombocytopenia in hepatitis C virus infection and chronic liver disease. Aliment Pharmacol Ther 2007, 26(Suppl 1):13-19.
13. Afdhal N, McHutchison J, Brown R, Jacobson I, Manns M, Poordad F, Weksler B, Esteban R. Thrombocytopenia associated with chronic liver disease. J Hepatol 2008, 48:1000-1007. 10.1016/j.jhep.2008.03.009, 18433919.
14. Giannini EG. Review article: Thrombocytopenia in chronic liver disease and pharmacologic treatment options. Aliment Pharmacol Ther 2006, 23:1055-1065. 10.1111/j.1365-2036.2006.02889.x, 16611265.
15. Khattab MA, Eslam M, Alavian SM. Hepatitis C Virus as a Multifaceted Disease: A Simple and Updated Approach for Extrahepatic Manifestations of Hepatitis C Virus Infection. Hepat Mon 2010, 10:258-269.
16. Aster RH. Pooling of platelets in spleen: role in the pathogenesis of ''hypersplenic'' thrombocytopenia. J Clin Invest 1966, 45:645-657. 10.1172/JCI105380, 292742, 5327481.
17. Adinolfi LE, Giordano MG, Andreana A, Tripodi MF, Utili R, Cesaro G, Ragone E, Durante Mangoni E, Ruggiero G. Hepatic fibrosis plays a central role in the pathogenesis of thrombocytopenia in patients with chronic viral hepatitis. Br J Haematol 2001, 113:590-595. 10.1046/j.1365-2141.2001.02824.x, 11380442.
18. Giannini E, Borro P, Botta F, Fumagalli A, Malfatti F, Podestà E, Romagnoli P, Testa E, Chiarbonello B, Polegato S, Mamone M, Testa R. Serum thrombopoietin levels are linked to liver function in untreated patients with hepatitis C virus-related chronic hepatitis. J Hepatol 2002, 37:572-577. 10.1016/S0168-8278(02)00274-X, 12399221.
19. Pereira J, Accatino L, Alfaro J, Brahm J, Hidalgo P, Mezzano D. Platelet autoantibodies in patients with chronic liver disease. Am J Hematol 1995, 50:173-178. 10.1002/ajh.2830500305, 7485078.
20. Aoki Y, Hirai K, Tanikawa K. Mechanism of thrombocytopenia in liver cirrhosis: kinetics of indium-111 tropolone labelled platelets. Eur J Nucl Med 1993, 20:123-129.
21. Nagamine T, Ohtuka T, Takehara K, Arai T, Takagi H, Mori M. Thrombocytopenia associated with hepatitis C viral infection. J Hepatol 1996, 24:135-140. 10.1016/S0168-8278(96)80021-3, 8907565.
22. Sanjo A, Satoi J, Ohnishi A, Maruno J, Fukata M, Suzuki N. Role of elevated platelet-associated immunoglobulin G and hypersplenism in thrombocytopenia of chronic liver diseases. J Gastroenterol Hepatol 2003, 18:638-644. 10.1046/j.1440-1746.2003.03026.x, 12753144.
23. Iga D, Tomimatsu M, Endo H, Ohkawa S, Yamada O. Improvement of thrombocytopenia with disappearance of HCV RNA in patients treated by interferon-a therapy: possible etiology of HCV-associated immune thrombocytopenia. Eur J Haematol 2005, 75:417-423. 10.1111/j.1600-0609.2005.00524.x, 16191092.
24. Bordin G, Ballaré M, Zigrossi P, Bertoncelli MC, Paccagnino L, Baroli A, Brambilla M, Monteverde A, Inglese E. A laboratory and thrombokinetic study of HCV-associated thrombocytopenia: a direct role of HCV in bone marrow exhaustion?. Clin Exp Rheumatol 1995, 13(suppl 13):S39-43.
25. Li X, Jeffers LJ, Garon C, Fischer ER, Scheffel J, Moore B, Reddy KR, Demedina M, Schiff ER. Persistence of hepatitis C virus in a human megakaryoblastic leukaemia cell line. J Viral Hepat 1999, 6:107-114. 10.1046/j.1365-2893.1999.00140.x, 10607221.
26. García-Suárez J, Burgaleta C, Hernanz N, Albarran F, Tobaruela P, Alvarez-Mon M. HCV-associated thrombocytopenia: clinical characteristics and platelet response after recombinant a2b-interferon therapy. Br J Haematol 2000, 110:98-103. 10.1046/j.1365-2141.2000.02132.x, 10930984.
27. Dai CY, Ho CK, Huang JF, Hsieh MY, Hou NJ, Lin ZY, Chen SC, Hsieh MY, Wang LY, Chang WY, Yu ML, Chuang WL. Hepatitis C virus viremia and low platelet count: a study in a hepatitis B & C endemic area in Taiwan. J Hepatol 2010, 52:160-166. 10.1016/j.jhep.2009.11.017, 20034694.
28. Ganser A, Carlo-Stella C, Greher A, Völkers B, Hoelzer D. Effect of recombinant interferons alpha and gamma on human bone marrow-derived megakaryocytic progenitor cells. Blood 1987, 70:1173-1179.
29. Dourakis SP, Deutsch M, Hadziyannis SJ. Immune thrombocytopenia and alpha-interferon therapy. J Hepatol 1996, 25:972-975. 10.1016/S0168-8278(96)80304-7, 9007728.
30. Peck-Radosavljevic M, Wichlas M, Pidlich J, Sims P, Meng G, Zacherl J, Garg S, Datz C, Gangl A, Ferenci P. Blunted thrombopoietin response to interferon alfa-induced thrombocytopenia during treatment for hepatitis C. Hepatology 1998, 28:424-1429.
31. Wang Q, Miyakawa Y, Fox N, Kaushansky K. Interferon-alpha directly represses megakaryopoiesis by inhibiting thrombopoietin-induced signaling through induction of SOCS-1. Blood 2000, 96:2093-2099.
32. Nachnani JS, Rao GA, Bulchandani D, Pandya PK, Alba LM. Predictors of hematological abnormalities in patients with chronic hepatitis C treated with interferon and ribavirin. Ann Hematol 2010, 89:121-125. 10.1007/s00277-009-0774-y, 19565241.
33. Promacta (eltrombopag) Portal venous system thromboses in study of patients with chronic liver disease. 2010 FDA Safety Alerts for Human Medical Products. Promacta (eltrombopag)., http://www.fda.gov/Safety/MedWatch/SafetyInformation/SafetyAlertsforHumanMedicalProducts/ucm196258.htm
34. Akahoshi T, Tomikawa M, Korenaga D, Ikejiri K, Saku M, Takenaka K. Laparoscopic splenectomy with peginterferon and ribavirin therapy for patients with hepatitis C virus cirrhosis and hypersplenism. Surg Endosc 2010, 24:680-685. 10.1007/s00464-009-0653-6, 19690915.
35. Foruny JR, Blázquez J, Moreno A, Bárcena R, Gil-Grande L, Quereda C, Pérez-Elías MJ, Moreno J, Sánchez J, Muriel A, Rodriguez-Sagrado MA, Moreno S. Safe use of pegylated interferon/ribavirin in hepatitis C virus cirrhotic patients with hypersplenism after partial splenic embolization. Eur J Gastroenterol Hepatol 2005, 17:1157-1164. 10.1097/00042737-200511000-00002, 16215426.
36. Alavian SM, Behnava B, Tabatabaei SH. The Comparative Efficacy and Safety of Peginterferon Alpha-2a vs. 2b for the Treatment of Chronic HCV Infection: A Meta-Analysis. Hepat Mon 2010, 10:121-31.