Spray Atomization Modeling for Tablet Film Coating Processes

Chemical Engineering in the Pharmaceutical Industry: R&D to Manufacturing

Volumn , Issue , 2010, Pages 781-799

  Aliseda, Alberto ^a   Berchielli, Alfred ^b   Doshi, Pankaj ^c   Lasheras, Juan C ^d  

^a University of Washington   (United States)

^b PFIZER INC   (United States)

^c NATIONAL CHEMICAL LABORATORY   (India)

^d UNIVERSITY OF CALIFORNIA SAN DIEGO   (United States)

Author keywords

Coating formulations, physical properties and rheology characterization; Mathematical modeling liquid breakup, and average droplet size; Spray atomization modeling for tablet film coating processes four processes in tablet coating operation

Indexed keywords

EID: 84862814107     PISSN: None     EISSN: None     Source Type: Book    
DOI: 10.1002/9780470882221.ch40     Document Type: Chapter

References (23)

1. Smith GW, Macleod GS, Fell JT. Mixing efficiency in sidevented coating equipment. AAPS PharmSciTech, 2003;4(3): E37.
2. Am Ende MT, Berchielli A. A thermodynamic model for organic and aqueous tablet film coating. Pharm. Dev. Technol., 2005;10(1):47-58.
3. Kalbag A, et al. Inter-tablet coating variability: residence times in a horizontal pan coater. Chem. Eng. Sci., 2008;63(11): 2881-2894.
4. Ebey GC. A thermodynamic model for aqueous film-coating. Pharm. Technol., 1987;11(4):40, 42-43, 46, 48, 50.
5. Porter SC, Felton LA. Techniques to assess film coatings and evaluate film-coated products. Drug Dev. Ind. Pharm. 36(2): 128-142.
6. McGinity JW, Felton LA, editors, Aqueous Polymeric Coatings for Pharmaceutical Dosage Forms, 3rd edition, Informa Healthcare, 2008, p. 488.
7. Turton R, Cheng XX. The scale-up of spray coating processes for granular solids and tablets. Powder Technol., 2005;150(2): 78-85.
8. Gibson SHM, Rowe RC, White EFT. Mechanical properties of pigmented tablet coating formulations and their resistance to cracking. I. Static mechanical measurement. Int. J. Pharm., 1988;48(1-3):63-77.
9. Aliseda A, et al. Atomization of viscous and non-Newtonian liquids by a coaxial, high-speed gas jet. Experiments and droplet size modeling. Int. J. Multiphase Flow, 2008;34 (2):161-175.
10. Mueller R, Kleinebudde P. Comparison of a laboratory and a production coating spray gun with respect to scale-up. AAPS PharmSciTech, 2007;8(1):3.
11. Mueller R, Kleinebudde P. Comparison study of laboratory and production spray guns in film coating: effect of pattern air and nozzle diameter. Pharm. Dev. Technol., 2006. 11(4):425-433.
12. Tobiska S, Kleinebudde P. Coating uniformity: influence of atomizing air pressure. Pharm. Dev. Technol., 2003;8(1): 39-46.
13. ThombreAG, et al. Osmotic drug delivery using swellable-core technology. J. Control. Release, 2004;94(1):75-89.
14. Thombre AG, et al. Asymmetric membrane capsules for osmotic drug delivery. II. In vitro and in vivo drug release performance. J. Control. Release, 1999;57(1):65-73.
15. Cole G, Hogan J, Aulton ME. Pharmaceutical Coating Technology, Informa Healthcare, 1995.
16. de Gennes PG, Brochard-Wyart F, Quere D. Capillary and Wetting Phenomena: Drops, Bubbles, Pearls, Waves, Springer, 2002.
17. Bachalo WD. Experimental methods in multiphase flows. Int. J. Multiphase Flow, 1994;20 (Suppl.):233-259.
18. Williams FA. Combustion Theory, 2nd edition, Addison Wesley, 1985.
19. Varga CM, Lasheras JC, Hopfinger EJ. Initial breakup of a small-diameter liquid jet by a high speed gas stream. J. Fluid Mech., 2003;497:405-434.
20. Marmottant P. Atomisation d'un courant liquide dans un courant gazeux, Institut National Polytechnique de Grenoble, Grenoble, 2001.
21. Joseph DD, Beaver GS, Funada T. Rayleigh-Taylor instability of viscoelastic drops at high Weber numbers. J. Fluid Mech., 2002;453:109-132.
22. Mansour A, Chigier N. Air-blast atomization of non-Newtonian liquids. J. Non-Newtonian Fluid Mech., 1995;58:161-194.
23. Lasheras JC, Hopfinger EJ. Liquid jet instability and atomization in a coaxial gas stream. Ann. Rev. Fluid Mech., 2000;32: 275-308.