Development of a fast and simple liquid chromatography-tandem mass spectrometry method for the quantitation of argatroban in patient plasma samples

Journal of Chromatography B: Analytical Technologies in the Biomedical and Life Sciences

Volumn 893-894, Issue , 2012, Pages 168-172

  Rhea, Jeanne M ^a   Snyder, Marion L ^b   Winkler, Anne M ^a   Abou Diwan, Charbel ^c   Fantz, Corinne R ^a   Ritchie, James C ^a   Szlam, Fania ^a   Tanaka, Kenichi A ^a   Molinaro, Ross J ^a  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b GREENVILLE HOSPITAL SYSTEM   (United States)

^c BANNER GOOD SAMARITAN MEDICAL CENTER   (United States)

Author keywords

Argatroban monitoring; Hemoclot Thrombin Inhibitors HTI ; Heparin Induced Thrombocytopenia (HIT); Hospitalized patient samples; Mass spectrometry; Method comparison; Plasma

Indexed keywords

ACQUITY; ACTIVITY-BASED; ARGATROBAN; CHROMATOGRAPHIC SEPARATIONS; CLINICAL CONDITIONS; CONCENTRATION RANGES; DICLOFENAC; DIRECT MEASUREMENT; GOOD CORRELATIONS; HEPARIN-INDUCED THROMBOCYTOPENIA (HIT); HOSPITALIZED PATIENT SAMPLES; HUMAN PLASMAS; INTERNAL STANDARDS; ION ELECTROSPRAY IONIZATION; LIQUID CHROMATOGRAPHY-TANDEM MASS SPECTROMETRY; LOWER LIMIT OF QUANTITATIONS; METHOD COMPARISON; MULTIPLE-REACTION MONITORING MODES; PLASMA FIBRINOGEN LEVELS; PLASMA SAMPLES; SIMPLE LIQUIDS; THROMBIN INHIBITORS; UPLC-MS/MS;

ELECTROSPRAY IONIZATION; FORMIC ACID; LIQUID CHROMATOGRAPHY; MASS SPECTROMETRY; METHANOL;

PLASMAS;

ARGATROBAN; DICLOFENAC; FIBRINOGEN; FORMIC ACID;

ARTICLE; BLOOD SAMPLING; DRUG BLOOD LEVEL; DRUG DETERMINATION; HOSPITAL PATIENT; HUMAN; HUMAN TISSUE; PRECIPITATION; PRIORITY JOURNAL; TANDEM MASS SPECTROMETRY; ULTRA PERFORMANCE LIQUID CHROMATOGRAPHY;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; DRUG MONITORING; HUMANS; LINEAR MODELS; PIPECOLIC ACIDS; REPRODUCIBILITY OF RESULTS; TANDEM MASS SPECTROMETRY;

EID: 84862813693     PISSN: 15700232     EISSN: 1873376X     Source Type: Journal    
DOI: 10.1016/j.jchromb.2012.02.041     Document Type: Article

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