N-glycans in liver-secreted and immunoglogulin-derived protein fractions

Journal of Proteomics

Volumn 75, Issue 7, 2012, Pages 2216-2224

  Bekesova, S ^a   Kosti, O ^a   Chandler, K B ^a   Wu, J ^a   Madej, H L ^a   Brown, K C ^a   Simonyan, V ^b   Goldman, R ^a  

^a GEORGETOWN UNIVERSITY   (United States)

^b CENTER FOR BIOLOGICS EVALUATION AND RESEARCH   (United States)

Author keywords

Liver disease; Mass spectrometry; N glycosylation; Serum

Indexed keywords

GLYCOPROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN D; IMMUNOGLOBULIN E; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LIVER PROTEIN; MANNOSE; PLASMA PROTEIN; PROTEIN A; PROTEIN G;

ADULT; ARTICLE; CLINICAL ARTICLE; CONTROLLED STUDY; FEMALE; HUMAN; LIVER CIRRHOSIS; MALE; MATRIX ASSISTED LASER DESORPTION IONIZATION TIME OF FLIGHT MASS SPECTROMETRY; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN GLYCOSYLATION; PROTEIN METHYLATION; PROTEIN SECRETION;

BLOOD PROTEINS; FEMALE; FIBROSIS; HUMANS; IMMUNOGLOBULINS; LIVER; MALE; POLYSACCHARIDES; SPECTROMETRY, MASS, MATRIX-ASSISTED LASER DESORPTION-IONIZATION;

EID: 84862813662     PISSN: 18743919     EISSN: 18767737     Source Type: Journal    
DOI: 10.1016/j.jprot.2012.01.024     Document Type: Article

References (53)

1. Williams R. Global challenges in liver disease. Hepatology Sep. 2006, 44(3):521-526.
2. Kuper H., Ye W., Broome U., Romelsjo A., Mucci L.A., Ekbom A., et al. The risk of liver and bile duct cancer in patients with chronic viral hepatitis, alcoholism, or cirrhosis. Hepatology Oct. 2001, 34(4 Pt 1):714-718.
3. Turner G.A. N-glycosylation of serum proteins in disease and its investigation using lectins. Clin Chim Acta Jun. 30, 1992, 208(3):149-171.
4. Cummings R.D. The repertoire of glycan determinants in the human glycome. Mol Biosyst Oct. 2009, 5(10):1087-1104.
5. Dube D.H., Bertozzi C.R. Glycans in cancer and inflammation-potential for therapeutics and diagnostics. Nat Rev Drug Discov Jun. 2005, 4(6):477-488.
6. Kiessling L.L., Splain R.A. Chemical approaches to glycobiology. Annu Rev Biochem 2010, 79:619-653.
7. Varki N.M., Strobert E., Dick E.J., Benirschke K., Varki A. Biomedical differences between human and nonhuman hominids: potential roles for uniquely human aspects of sialic acid biology. Annu Rev Pathol Feb. 28, 2011, 6:365-393.
8. Vanderschaeghe D., Laroy W., Sablon E., Halfon P., Van H.A., Delanghe J., et al. GlycoFibroTest is a highly performant liver fibrosis biomarker derived from DNA sequencer-based serum protein glycomics. Mol Cell Proteomics May 2009, 8(5):986-994.
9. Klein A., Carre Y., Louvet A., Michalski J.C., Morelle W. Immunoglobulins are the major glycoproteins involved in the modifications of total serum N-glycome in cirrhotic patients. Proteomics Clin Appl Apr. 2010, 4(4):379-393.
10. Mehta A.S., Long R.E., Comunale M.A., Wang M., Rodemich L., Krakover J., et al. Increased levels of galactose-deficient anti-Gal immunoglobulin G in the sera of hepatitis C virus-infected individuals with fibrosis and cirrhosis. J Virol Feb. 2008, 82(3):1259-1270.
11. Adamson J.T., Hakansson K. Electron capture dissociation of oligosaccharides ionized with alkali, alkaline Earth, and transition metals. Anal Chem Apr. 1, 2007, 79(7):2901-2910.
12. Arnold J.N., Radcliffe C.M., Royle L., Dwek R.A., Rudd P.M., Sim R.B. Immunoglobulin glycosylation: the search for MBL binding targets. Mol Immunol Jun. 2004, 41(2-3):203-204.
13. Lee F.I. Immunoglobulins in viral hepatitis and active alcoholic liver-disease. Lancet Nov. 20, 1965, 2(7421):1043-1046.
14. Becker W. Variations of immunoglobulins in disease. J Clin Pathol Suppl (Assoc Clin Pathol) 1975, 6:92-101.
15. Thiele G.M., Freeman T.L., Klassen L.W. Immunologic mechanisms of alcoholic liver injury. Semin Liver Dis Aug, 2004, 24(3):273-287.
16. Klein A., Michalski J.C., Morelle W. Modifications of human total serum N-glycome during liver fibrosis-cirrhosis, is it all about immunoglobulins?. Proteomics Clin Appl Apr. 2010, 4(4):372-378.
17. Comunale M.A., Rodemich-Betesh L., Hafner J., Wang M.J., Norton P., Di Bisceglie A.M., et al. Linkage specific fucosylation of alpha-1-antitrypsin in liver cirrhosis and cancer patients: implications for a biomarker of hepatocellular carcinoma. PLoS One Aug. 25, 2010, 5(8).
18. Zhang S., Shu H., Luo K.X., Kang X.N., Zhang Y., Lu H.J., et al. N-linked glycan changes of serum haptoglobin beta chain in liver disease patients. Mol Biosyst 2011, 7(5):1621-1628.
19. Kang P., Mechref Y., Klouckova I., Novotny M.V. Solid-phase permethylation of glycans for mass spectrometric analysis. Rapid Commun Mass Spectrom 2005, 19(23):3421-3428.
20. Kang P., Mechref Y., Novotny M.V. High-throughput solid-phase permethylation of glycans prior to mass spectrometry. Rapid Commun Mass Spectrom 2008, 22(5):721-734.
21. Goldman R., Ressom H.W., Varghese R.S., Goldman L., Bascug G., Loffredo C.A., et al. Detection of hepatocellular carcinoma using glycomic analysis. Clin Cancer Res Mar. 1, 2009, 15(5):1808-1813.
22. Ressom H.W., Varghese R.S., Goldman L., An Y., Loffredo C.A., bdel-Hamid M., et al. Analysis of MALDI-TOF mass spectrometry data for discovery of peptide and glycan biomarkers of hepatocellular carcinoma. J Proteome Res Feb. 2008, 7(2):603-610.
23. Tang Z., Varghese R.S., Bekesova S., Loffredo C.A., Hamid M.A., Kyselova Z., et al. Identification of N-glycan serum markers associated with hepatocellular carcinoma from mass spectrometry data. J Proteome Res Jan. 2010, 9(1):104-112.
24. Tang H., Mechref Y., Novotny M.V. Automated interpretation of MS/MS spectra of oligosaccharides. Bioinformatics Jun. 2005, 21(Suppl. 1):i431-i439.
25. Yang C., He Z., Yu W. Comparison of public peak detection algorithms for MALDI mass spectrometry data analysis. BMC Bioinformatics 2009, 10:4.
26. Coombes K.R., Tsavachidis S., Morris J.S., Baggerly K.A., Hung M.C., Kuerer H.M. Improved peak detection and quantification of mass spectrometry data acquired from surface-enhanced laser desorption and ionization by denoising spectra with the undecimated discrete wavelet transform. Proteomics Nov. 2005, 5(16):4107-4117.
27. Goldberg D., Sutton-Smith M., Paulson J., Dell A. Automatic annotation of matrix-assisted laser desorption/ionization N-glycan spectra. Proteomics Mar. 2005, 5(4):865-875.
28. Morelle W., Flahaut C., Michalski J.C., Louvet A., Mathurin P., Klein A. Mass spectrometric approach for screening modifications of total serum N-glycome in human diseases: application to cirrhosis. Glycobiology Apr. 2006, 16(4):281-293.
29. Arnold J.N., Wormald M.R., Suter D.M., Radcliffe C.M., Harvey D.J., Dwek R.A., et al. Human serum IgM glycosylation-identification of glycoforms that can bind to mannan-binding lectin. J Biol Chem Aug. 12, 2005, 280(32):29080-29087.
30. Blomme B., Van S.C., Callewaert N., Van V.H. Alteration of protein glycosylation in liver diseases. J Hepatol Mar. 2009, 50(3):592-603.
31. Martinez J., Barsigian C. Carbohydrate abnormalities of N-linked plasma glycoproteins in liver disease. Lab Invest Sep. 1987, 57(3):240-257.
32. Gravel P., Walzer C., Aubry C., Balant L.P., Yersin B., Hochstrasser D.F., et al. New alterations of serum glycoproteins in alcoholic and cirrhotic patients revealed by high resolution two-dimensional gel electrophoresis. Biochem Biophys Res Commun Mar. 7, 1996, 220(1):78-85.
33. Thompson S., Matta K.L., Turner G.A. Changes in fucose metabolism associated with heavy drinking and smoking: a preliminary report. Clin Chim Acta Sep. 14, 1991, 201(1-2):59-64.
34. Mann A.C., Record C.O., Self C.H., Turner G.A. Monosaccharide composition of haptoglobin in liver diseases and alcohol abuse: large changes in glycosylation associated with alcoholic liver disease. Clin Chim Acta Jun. 1994, 227(1-2):69-78.
35. Hada T., Kondo M., Yasukawa K., Amuro Y., Higashino K. Discrimination of liver cirrhosis from chronic hepatitis by measuring the ratio of Aleuria aurantia lectin-reactive serum cholinesterase to immunoreactive protein. Clin Chim Acta Mar. 1999, 281(1-2):37-46.
36. Ryden I., Pahlsson P., Lindgren S. Diagnostic accuracy of alpha(1)-acid glycoprotein fucosylation for liver cirrhosis in patients undergoing hepatic biopsy. Clin Chem Dec. 2002, 48(12):2195-2201.
37. Marino K., Bones J., Kattla J.J., Rudd P.M. A systematic approach to protein glycosylation analysis: a path through the maze. Nat Chem Biol Oct. 2010, 6(10):713-723.
38. Mechref Y., Novotny M.V. Miniaturized separation techniques in glycomic investigations. J Chromatogr B Analyt Technol Biomed Life Sci Sep. 1, 2006, 841(1-2):65-78.
39. Bones J., Mittermayr S., O'Donoghue N., Guttman A., Rudd P.M. Ultra performance liquid chromatographic profiling of serum N-glycans for fast and efficient identification of cancer associated alterations in glycosylation. Anal Chem Dec. 15, 2010, 82(24):10208-10215.
40. Szabo Z., Guttman A., Rejtar T., Karger B.L. Improved sample preparation method for glycan analysis of glycoproteins by CE-LIF and CE-MS. Electrophoresis Apr. 2010, 31(8):1389-1395.
41. Royle L., Dwek R.A., Rudd P.M. Determining the structure of oligosaccharides N- and O-linked to glycoproteins. Curr Protoc Protein Sci Mar. 2006, Chapter 12:6.1-45.
42. Ahn J., Bones J., Yu Y.Q., Rudd P.M., Gilar M. Separation of 2-aminobenzamide labeled glycans using hydrophilic interaction chromatography columns packed with 1.7 mu m sorbent. J Chromatogr B Analyt Technol Biomed Life Sci Feb. 1, 2010, 878(3-4):403-408.
43. Harvey D.J. Structural determination of N-linked glycans by matrix-assisted laser desorption/ionization and electrospray ionization mass spectrometry. Proteomics May 2005, 5(7):1774-1786.
44. Madi A., Lakhdari O., Blottiere H.M., Guyard-Nicodeme M., Le R.K., Groboillot A., et al. The clinical Pseudomonas fluorescens MFN1032 strain exerts a cytotoxic effect on epithelial intestinal cells and induces Interleukin-8 via the AP-1 signaling pathway. BMC Microbiol 2010, 10:215.
45. Ashline D., Singh S., Hanneman A., Reinhold V. Congruent strategies for carbohydrate sequencing. 1. Mining structural details by MSn. Anal Chem Oct. 1, 2005, 77(19):6250-6262.
46. Stumpo K.A., Reinhold V.N. The N-glycome of human plasma. J Proteome Res Sep. 2010, 9(9):4823-4830.
47. Stanta J.L., Saldova R., Struwe W.B., Byrne J.C., Leweke F.M., Rothermund M., et al. Identification of N-glycosylation changes in the CSF and serum in patients with schizophrenia. J Proteome Res Sep. 2010, 9(9):4476-4489.
48. Wu S., Grimm R., German J.B., Lebrilla C.B. Annotation and structural analysis of sialylated human milk oligosaccharides. J Proteome Res Feb. 4, 2011, 10(2):856-868.
49. Lattova E., McKenzie E.J., Gruwel M.L.H., Spicer V., Goldman R., Perreault H. Mass spectrometric study of N-glycans from serum of woodchucks with liver cancer. Rapid Commun Mass Spectrom Sep. 2009, 23(18):2983-2995.
50. Harada H., Kamei M., Tokumoto Y., Yui S., Koyama F., Kochibe N., et al. Systematic fractionation of oligosaccharides of human immunoglobulin G by serial affinity chromatography on immobilized lectin columns. Anal Biochem Aug. 1, 1987, 164(2):374-381.
51. Arnold J.N., Wallis R., Willis A.C., Harvey D.J., Royle L., Dwek R.A., et al. Interaction of mannan binding lectin with alpha(2) macroglobulin via exposed oligomannose glycans-a conserved feature of the thiol ester protein family?. J Biol Chem Mar. 17, 2006, 281(11):6955-6963.
52. Ritchie G.E., Moffatt B.E., Sim R.B., Morgan B.P., Dwek R.A., Rudd P.M. Glycosylation and the complement system. Chem Rev Feb. 2002, 102(2):305-319.
53. Knezevic A., Polasek O., Gornik O., Rudan I., Campbell H., Hayward C., et al. Variability, heritability and environmental determinants of human plasma N-glycome. J Proteome Res Feb. 2009, 8(2):694-701.