Protection by cilostazol against amyloid-β 1-40-induced suppression of viability and neurite elongation through activation of CK2α in HT22 mouse hippocampal cells

Journal of Neuroscience Research

Volumn 90, Issue 8, 2012, Pages 1566-1576

  Lee, Hye Rin ^a   Park, So Youn ^a   Kim, Hye Young ^a   Shin, Hwa Kyoung ^a   Lee, Won Suk ^a,b   Rhim, Byung Yong ^b   Hong, Ki Whan ^a   Kim, Chi Dae ^a,b  

^a Pusan National University   (South Korea)

^b Pusan National University School of Medicine   (South Korea)

Author keywords

catenin; Amyloid peptide; Cilostazol; CK2 ; GSK 3 ; P53

Indexed keywords

AMYLOID BETA PROTEIN[1-40]; BETA CATENIN; CASEIN KINASE II; CASPASE 3; CILOSTAZOL; GLYCOGEN SYNTHASE KINASE 3BETA; PROTEIN BAX; PROTEIN BCL 2; PROTEIN P53; SERINE;

ANIMAL CELL; ARTICLE; CELL VIABILITY; CONTROLLED STUDY; DRUG EFFECT; DRUG MECHANISM; ENZYME ACTIVATION; ENZYME PHOSPHORYLATION; HIPPOCAMPUS; MOUSE; NERVE CELL; NERVE FIBER GROWTH; NEUROPROTECTION; NONHUMAN; NUCLEOTIDE SEQUENCE; PRIORITY JOURNAL; PROTEIN EXPRESSION; SIGNAL TRANSDUCTION;

AMYLOID BETA-PEPTIDES; ANIMALS; APOPTOSIS; BLOTTING, WESTERN; CASEIN KINASE II; CELL LINE; CELL PROLIFERATION; CELL SURVIVAL; ENZYME ACTIVATION; GENE KNOCKDOWN TECHNIQUES; HIPPOCAMPUS; MICE; NEURITES; NEUROPROTECTIVE AGENTS; RNA, SMALL INTERFERING; SIGNAL TRANSDUCTION; TETRAZOLES; TRANSFECTION;

EID: 84862802141     PISSN: 03604012     EISSN: 10974547     Source Type: Journal    
DOI: 10.1002/jnr.23037     Document Type: Article

References (24)

1. Arai H, Takahashi T. 2009. A combination therapy of donepezil and cilostazol for patients with moderate Alzheimer disease: pilot follow-up study. Am J Geriatr Psychiatry 17: 353-354.
2. Arevalo MA, Rodríguez-Tébar A. 2006. Activation of casein kinase II and inhibition of phosphatase and tensin homologue deleted on chromosome 10 phosphatase by nerve growth factor/p75NTR inhibit glycogen synthase kinase-3beta and stimulate axonal growth. Mol Biol Cell 17: 3369-3377.
3. Bhat RV, Shanley J, Correll MP, Fieles WE, Keith RA, Scott CW, Lee CM. 2000. Regulation and localization of tyrosine 216 phosphorylation of glycogen synthase kinase-3β in cellular and animal models of neuronal degeneration. Proc Natl Acad Sci U S A 97: 11074-11079.
4. Caricasole A, Copani A, Caruso A, Caraci F, Iacovelli L, Sortino MA, Terstappen GC, Nicoletti F. 2003. The Wnt pathway, cell-cycle activation and beta-amyloid: novel therapeutic strategies in Alzheimer's disease? Trends Pharmacol Sci 24: 233-238.
5. Cenini G, Sultana R, Memo M, and Butterfield DA. 2008. Effects of oxidative and nitrosative stress in brain on p53 proapoptotic protein in amnestic mild cognitive impairment and Alzheimer disease. Free Radic Biol Med 45: 81-85.
6. Chipuk JE, Green DR. 2004. Cytoplasmic p53: Bax and forward. Cell Cycle 3: 429-431.
7. Copani A, Sortino MA, Caricasole A, Chiechio S, Chisari M, Battaglia G, Giuffrida-Stella AM, Vancheri C, Nicoletti F. 2002. Erratic expression of DNA polymerases by beta-amyloid causes neuronal death. FASEB J 16: 2006-2008.
8. Hardy J, Selkoe DJ. 2002. The amyloid hypothesis of Alzheimer's disease: progress and problems on the road to therapeutics. Science 297: 353-356.
9. Hashimoto K, Ishima T. 2011. Neurite outgrowth mediated by translation elongation factor eEF1A1: a target for antiplatelet agent cilostazol. PLoS One 6: e17431.
10. Hino S, Tanji C, Nakayama KI, Kikuchi A. 2005. Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination. Mol Cell Biol 25: 9063-9072.
11. Hong KW, Lee JH, Kim KY, Park SY, Lee WS. 2006. Cilostazol: therapeutic potential against focal cerebral ischemic damage. Curr Pharm Des 12: 565-573.
12. Kim KY, Shin HK, Lee JH, Kim CD, Lee WS, Rhim BY, Shin YW, Hong KW. 2004. Cilostazol enhances casein kinase 2 phosphorylation and suppresses tumor necrosis factor-alpha-induced increased phosphatase and tensin homolog deleted from chromosome 10 phosphorylation and apoptotic cell death in SK-N-SH cells. J Pharmacol Exp Ther 308: 97-104.
13. Kleijn M, Welsh GI, Scheper GC, Voorma HO, Proud CG, Thomas AA. 1998. Nerve and epidermal growth factor induce protein synthesis and eIF2B activation in PC12 cells. J Biol Chem 273: 5536-5541.
14. Lee JH, Kim KY, Lee YK, Park SY, Kim CD, Lee WS, Rhim BY, Hong KW. 2004. Cilostazol prevents focal cerebral ischemic injury by enhancing casein kinase 2 phosphorylation and suppression of phosphatase and tensin homolog deleted from chromosome 10 phosphorylation in rats. J Pharmacol Exp Ther 308: 896-903.
15. Lee JH, Park SY, Shin YW, Hong KW, Kim CD, Sung SM, Kim KY, Lee WS. 2006. Neuroprotection by cilostazol, a phosphodiesterase type 3 inhibitor, against apoptotic white matter changes in rat after chronic cerebral hypoperfusion. Brain Res 1082: 182-191.
16. Lee JH, Park SY, Shin YW, Kim CD, Lee WS, Hong KW. 2007. Concurrent administration of cilostazol with donepezil effectively improves cognitive dysfunction with increased neuroprotection after chronic cerebral hypoperfusion in rats. Brain Res 1185: 246-255.
17. Leroy K, Yilmaz Z, Brion J-P. 2007. Increased level of active GSK-3β in Alzheimer's disease and accumulation in argyrophilic grains and in neurones at different stages of neurofibrillary degeneration. Neuropathol Applied Neurobiol 33: 43-55.
18. Litchfield DW. 2003. Protein kinase CK2α: structure, regulation and role in cellular decisions of life and death. Biochem J 369: 1-15.
19. Park SH, Kim JH, Bae SS, Hong KW, Lee DS, Leem JY, Choi BT, Shin HK. 2011. Protective effect of the phosphodiesterase III inhibitor cilostazol on beta-amyloid-induced cognitive deficits associated with decreased amyloid β accumulation. Biochem Biophys Res Commun 408: 602-608.
20. Schuler M, Green DR. 2001. Mechanisms of p53-dependent apoptosis. Biochem Soc Trans 29: 684-688.
21. Ulloa L, Díaz-Nido J, Avila J. 1993. Depletion of casein kinase II by antisense oligonucleotide prevents neuritogenesis in neuroblastoma cells. EMBO J 12: 1633-1640.
22. van Oijen M, Hofman MA, Soares HD, Koudstaal PJ, Breteler MB. 2006. Plasma Aβ1-40 and Aβ1-42 and the risk of dementia: a prospective case-cohort study. Lancet Neurol 5: 655-660.
23. Wiltfang J, Esselmann H, Bibl M, Smirnov A, Otto M, Paul S, Schmidt B, Klafki HW, Maler M, Dyrks T, Bienert M, Beyermann M, Ruther E, Kornhuber J. 2002. Highly conserved and disease-specific patterns of carboxyterminally truncated Abeta peptides 1-37/38/39 in addition to 1-40/42 in Alzheimer's disease and in patients with chronic neuroinflammation. J Neurochem 81: 481-496.
24. Wyttenbach A, Tolkovsky AM. 2006. The BH3-only protein Puma is both necessary and sufficient for neuronal apoptosis induced by DNA damage in sympathetic neurons. J Neurochem 96: 1213-1226.