Lentivirus-mediated silencing of I2PP2A through RNA interference attenuates trichloroethylene-induced cytotoxicity in human hepatic L-02 cells

Toxicology Letters

Volumn 209, Issue 3, 2012, Pages 232-238

  Yang, Xifei ^a   Jiang, Yingzhi ^a   Li, Jie ^a   Hong, Wen xu ^a   Wu, Desheng ^a   Huang, Xinfeng ^a   Huang, Haiyan ^a   Zhou, Li ^a   Yang, Lingqing ^a   Yuan, Jianhui ^a   Zhuang, Zhixiong ^a   Liu, Jianjun ^a  

^a SHENZHEN CENTER FOR DISEASE CONTROL AND PREVENTION   (China)

Author keywords

I2PP2A; Protein phosphatase (PP) 2A; SiRNA; Trichloroethylene (TCE)

Indexed keywords

CASPASE 3; MESSENGER RNA; PHOSPHOPROTEIN PHOSPHATASE 2A; SMALL INTERFERING RNA; TRICHLOROETHYLENE;

APOPTOSIS; ARTICLE; CELL LEVEL; CELL VIABILITY; CONTROLLED STUDY; CYTOTOXICITY; DRUG EFFECT; ENZYME ACTIVATION; ENZYME ACTIVITY; ENZYME INDUCTION; ENZYME INHIBITION; GENE SILENCING; HUMAN; HUMAN CELL; LENTIVIRINAE; LIVER TOXICITY; PRIORITY JOURNAL; RNA INTERFERENCE;

APOPTOSIS; CELL LINE; CELL SURVIVAL; ENVIRONMENTAL POLLUTANTS; GENE KNOCKDOWN TECHNIQUES; GENETIC VECTORS; HISTONE CHAPERONES; HUMANS; LENTIVIRUS; LIVER; REAL-TIME POLYMERASE CHAIN REACTION; RNA INTERFERENCE; RNA, SMALL INTERFERING; TRANSCRIPTION FACTORS; TRANSFECTION; TRICHLOROETHYLENE;

LENTIVIRUS;

EID: 84862801501     PISSN: 03784274     EISSN: 18793169     Source Type: Journal    
DOI: 10.1016/j.toxlet.2011.12.019     Document Type: Article

References (29)

1. Agency for Toxic Substances and Disease Registry (ATSDR) Toxicological Profile for Trichloroethylene 1977, Unite States Department of Health and Human Services, Atlanta, GA, USA.
2. Al-Murrani S.W., Woodgett J.R., Damuni Z. Expression of I2PP2A, an inhibitor of protein phosphatase 2A, induces c-Jun and AP-1 activity. Biochem. J. 1999, 341:293-298.
3. Atkinson A., Meeks R.G., Roy D. Increased oxidative stress in the liver of mice treated with trichloroethylene. Biochem. Mol. Biol. Int. 1993, 31:297-304.
4. Bakke B., Stewart P.A., Waters M.A. Uses of and exposure to trichloroethylene in U.S. industry: a systematic literature review. J. Occup. Environ. Hyg. 2007, 4:375-390.
5. Eichhorn P.J., Creyghton M.P., Bernards R. Protein phosphatase 2A regulatory subunits and cancer. Biochim. Biophys. Acta 2009, 1795:1-15.
6. Fukukawa C., Shima H., Tanuma N., Ogawa K., Kikuchi K. Up-regulation of I-2(PP2A)/SET gene expression in rat primary hepatomas and regenerating livers. Cancer Lett. 2000, 161:89-95.
7. Goldman S.M. Trichloroethylene and Parkinson's disease: dissolving the puzzle. Expert. Rev. Neurother. 2010, 10:835-837.
8. Griffin J.M., Gilbert K.M., Lamps L.W., Pumford N.R. CD4(+) T-cell activation and induction of autoimmune hepatitis following trichloroethylene treatment in MRL+/+ mice. Toxicol. Sci. 2000, 57:345-352.
9. Hu C., Jiang L., Geng C., Zhang X., Cao J., Zhong L. Possible involvement of oxidative stress in trichloroethylene-induced genotoxicity in human HepG2 cells. Mutat. Res. 2008, 652:88-94.
10. Kadry A.M., Farghali H., Abdel-Rahman M.S. Toxicity and metabolism of trichloroethylene in rat hepatocytes. Arch. Environ. Contam. Toxicol. 1989, 18:888-894.
11. Kaindl A.M., Sifringer M., Zabel C., Nebrich G., Wacker M.A., Felderhoff-Mueser U., Endesfelder S., von der Hagen M., Stefovska V., Klose J., Ikonomidou C. Acute and long-term proteome changes induced by oxidative stress in the developing brain. Cell. Death. Differ. 2006, 13:1097-1109.
12. Kumar P., Prasad A.K., Maji B.K., Mani U., Dutta K.K. Hepatoxic alterations induced by inhalation of trichlorethylene (TCE) in rats. Biomed. Environ. Sci. 2001, 14:325-332.
13. Lash L.H., Fisher J.W., Lipscomb J.C., Parker J.C. Metabolism of trichloroethylene. Environ. Health. Perspect. 2000, 108:177-200.
14. Lee K.M., Muralidhara S., Schnellmann R.G., Bruckner J.V. Contribution of direct solvent injury to the dose-dependent kinetics of trichloroethylene: portal vein administration to rats. Toxicol. Appl. Pharmacol. 2000, 164:46-54.
15. Li M., Makkinje A., Damuni Z. The myeloid leukemia-associated protein SET is a potent inhibitor of protein phosphatase 2A. J. Biol. Chem. 1996, 271:11059-11062.
16. Liu.J., Huang H., Xing X., Xi R., Zhuang Z., Yuan J., Yang F., Zhao J. Comparative proteomic analysis on human L-02 liver cells treated with varying concentrations of trichloroethylene. Toxicol. Ind. Health. 2007, 23:91-101.
17. Madeira A., Pommet J.M., Prochiantz A., Allinquant B. SET protein (TAF1beta, I2PP2A) is involved in neuronal apoptosis induced by an amyloid precursor protein cytoplasmic subdomain. FASEB J. 2005, 19:1905-1907.
18. Pantucharoensri S., Boontee P., Likhitsan P., Padungtod C., Prasartsansoui S. Generalized eruption accompanied by hepatitis in two Thai metal cleaners exposed to trichloroethylene. Ind. Health. 2004, 42:385-388.
19. Phoon W.H., Chan M.O., Rajan V.S., Tan K.J., Thirumoorthy T., Goh C.L. Stevens-Johnson syndrome associated with occupational exposure to trichloroethylene. Contact. Dermatiti. 1984, 10:270-276.
20. Prout M.S., Provan W.M., Green T. Species differences in response to trichloroethylene. I. Pharmacokinetics in rats and mice. Toxicol. Appl. Pharmacol. 1985, 79:389-400.
21. Purdue M.P., Bakke B., Stewart P., De Roos A.J., Schenk M., Lynch C.F., Bernstein L., Morton L.M., Cerhan J.R., Severson R.K., Cozen W., Davis S., Rothman N., Hartge P., Colt J.S. A case-control study of occupational exposure to trichloroethylene and non-Hodgkin lymphoma. Environ. Health. Perspect. 2011, 119:232-238.
22. Tabrez S., Ahmad M. Toxicity, biomarkers, genotoxicity, and carcinogenicity of trichloroethylene and its metabolites: a review. J. Environ. Sci. Health. C: Environ. Carcinog. Ecotoxicol. Rev. 2009, 27:178-196.
23. Tabrez S., Ahmad M. Some enzymatic/non enzymatic antioxidants as potential stress biomarkers of trichloroethylene, heavy metal mixture and ethyl alcohol in rat tissues. Environ. Toxicol. 2011, 26:207-216.
24. Tabrez S., Ahmad M. Genotoxicity of trichloroethylene in the natural milieu. Int. J. Hyg. Environ. Health 2011, Sep 13. (Epub ahead of print). 10.1016/j.ijheh.2011.08.004.
25. Thiele D.L., Eigenbrodt E.H., Ware A.J. Cirrhosis after repeated trichloroethylene and 1,1,1-trichloroethane exposure. Gastroenterology 1982, 83:926-929.
26. Trotta R., Ciarlariello D., Dal Col J., Allard J., Nevianim P., Santhanam R., Mao H., Becknell B., Yum J., Ferketichm A.K., Thomas B., Modi A., Blaser B.W., Perrotti D., Caligiuri M.A. The PP2A inhibitor SET regulates natural killer cell IFN-gamma production. J. Exp. Med. 2007, 204:2397-2405.
27. Von Lindern M., van Baal S., Wiegant J., Raap A., Hagemeijer A., Grosveld G. Can, a putative oncogene associated with myeloid leukemogenesis, may be activated by fusion of its 3' half to different genes: characterization of the set gene. Mol. Cell. Biol. 1992, 12:346-355.
28. Westermarck J., Hahn W.C. Multiple pathways regulated by the tumor suppressor PP2A in transformation. Trends Mol. Med. 2008, 14:152-160.
29. Xia L., Yu T. Study of the relationship between the hepatotoxicity and free radical induced by 1,1,2-trichloroethane and 1,1,1-trichloroethane in rat. Biomed. Environ. Sci. 1992, 5:303-313.