Hepatocellular necrosis, fibrosis and microsomal activity determine the hepatic pharmacokinetics of basic drugs in right-heart-failure-induced liver damage

Pharmaceutical Research

Volumn 29, Issue 6, 2012, Pages 1658-1669

  Li, Peng ^a,b   Robertson, Thomas A ^a,b   Zhang, Qian ^a,b   Fletcher, Linda M ^b   Crawford, Darrell H G ^b   Weiss, Michael ^c   Roberts, Michael S ^a,b  

^a UNIVERSITY OF SOUTH AUSTRALIA   (Australia)

^b UNIVERSITY OF QUEENSLAND   (Australia)

^c MARTIN LUTHER UNIVERSITY HALLE WITTENBERG   (Germany)

Author keywords

fibrosis index; hepatic pharmacokinetics; hepatocellular necrosis; in situ perfused rat liver; right heart failure

Indexed keywords

ALANINE AMINOTRANSFERASE; ALBUMIN; ALKALINE PHOSPHATASE; ASPARTATE AMINOTRANSFERASE; ATENOLOL; BILIRUBIN; CYTOCHROME P450; LABETALOL; METOPROLOL; PHENAZONE; PROPRANOLOL;

ALANINE AMINOTRANSFERASE BLOOD LEVEL; ALBUMIN BLOOD LEVEL; ALKALINE PHOSPHATASE BLOOD LEVEL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; AREA UNDER THE CURVE; ARTICLE; ASPARTATE AMINOTRANSFERASE BLOOD LEVEL; BILIRUBIN BLOOD LEVEL; CONTROLLED STUDY; DRUG CLEARANCE; DRUG DISTRIBUTION; DRUG ELIMINATION; DRUG METABOLISM; DRUG PENETRATION; HEART RIGHT VENTRICLE FAILURE; HISTOPATHOLOGY; INTRAVASCULAR SPACE; LIPOPHILICITY; LIVER FIBROSIS; LIVER MICROSOME; LIVER NECROSIS; MALE; NONHUMAN; NUCLEOTIDE SEQUENCE; PATHOPHYSIOLOGY; PHYSICAL CHEMISTRY; PRIORITY JOURNAL; RAT; SINGLE DRUG DOSE;

ADRENERGIC ANTAGONISTS; ANALYSIS OF VARIANCE; ANIMALS; ANTI-INFLAMMATORY AGENTS, NON-STEROIDAL; ANTIPYRINE; ATENOLOL; CELL MEMBRANE PERMEABILITY; CYTOCHROME P-450 ENZYME SYSTEM; DISEASE MODELS, ANIMAL; GENE EXPRESSION REGULATION, ENZYMOLOGIC; HEART FAILURE; LABETALOL; LINEAR MODELS; LIVER; LIVER CIRRHOSIS; LIVER DISEASES; MALE; METABOLIC CLEARANCE RATE; METOPROLOL; MICROSOMES, LIVER; MODELS, BIOLOGICAL; NECROSIS; NONLINEAR DYNAMICS; PERFUSION; PROPRANOLOL; RATS; RATS, WISTAR; REAL-TIME POLYMERASE CHAIN REACTION; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION;

EID: 84862798010     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0690-z     Document Type: Article

References (45)

1. GM Felker LA Allen SJ Pocock LK Shaw JJ McMurray MA Pfeffer, et al. 2007 Red cell distribution width as a novel prognostic marker in heart failure: data from the CHARM Program and the Duke Databank J Am Coll Cardiol 50 1 40 47 17601544 10.1016/j.jacc.2007.02.067
2. LA Allen GM Felker S Pocock JJ McMurray MA Pfeffer K Swedberg, et al. 2009 Liver function abnormalities and outcome in patients with chronic heart failure: data from the Candesartan in Heart Failure: Assessment of Reduction in Mortality and Morbidity (CHARM) program Eur J Heart Fail 11 2 170 177 19168515 10.1093/eurjhf/hfn031
3. CC Giallourakis PM Rosenberg LS Friedman 2002 The liver in heart failure Clin Liver Dis 6 4 947 967 12516201 10.1016/S1089-3261(02)00056-9 viii-ix
4. RK Seeto B Fenn DC Rockey 2000 Ischemic hepatitis: clinical presentation and pathogenesis Am J Med 109 2 109 113 10967151 10.1016/S0002-9343(00)00461-7 1:STN:280:DC%2BD3cvosV2hsA%3D%3D
5. RL Williams RD Mamelok 1980 Hepatic disease and drug pharmacokinetics Clin Pharmacokinet 5 6 528 547 7002418 10.2165/00003088-198005060-00002 1:STN:280:DyaL3M%2FmsFKhsQ%3D%3D
6. DY Hung P Chang K Cheung B McWhinney PP Masci M Weiss, et al. 2002 Cationic drug pharmacokinetics in diseased livers determined by fibrosis index, hepatic protein content, microsomal activity, and nature of drug J Pharmacol Exp Ther 301 3 1079 1087 12023540 10.1124/jpet.301.3.1079 1:CAS:528: DC%2BD38XktlGjsbg%3D
7. DY Hung P Chang K Cheung C Winterford MS Roberts 2002 Quantitative evaluation of altered hepatic spaces and membrane transport in fibrotic rat liver Hepatology 36 5 1180 1189 12395328 10.1053/jhep.2002.36820
8. GA Siebert DY Hung P Chang MS Roberts 2004 Ion-trapping, microsomal binding, and unbound drug distribution in the hepatic retention of basic drugs J Pharmacol Exp Ther 308 1 228 235 14566005 10.1124/jpet.103.056770 1:CAS:528:DC%2BD2cXmsFegtw%3D%3D
9. P Li TA Robertson CA Thorling Q Zhang LM Fletcher DH Crawford, et al. 2011 Hepatic pharmacokinetics of cationic drugs in a high-fat emulsion-induced rat model of nonalcoholic steatohepatitis Drug Metabol Dispos 39 4 571 579 10.1124/dmd.110.036806 1:CAS:528:DC%2BC3MXkslSlsLs%3D
10. CY Ng H Ghabrial DJ Morgan MS Ching RA Smallwood PW Angus 2000 Impaired elimination of propranolol due to right heart failure: drug clearance in the isolated liver and its relationship to intrinsic metabolic capacity Drug Metab Dispos 28 10 1217 1221 10997943 1:CAS:528:DC%2BD3cXntVSlt7w%3D
11. G Jurgens HR Christensen K Brosen J Sonne S Loft NV Olsen 2002 Acute hypoxia and cytochrome P450-mediated hepatic drug metabolism in humans Clin Pharmacol Ther 71 4 214 220 11956503 10.1067/mcp.2002.121789 1:CAS:528:DC%2BD38Xjs1ersbw%3D
12. CY Ng H Ghabrial DJ Morgan MS Ching RA Smallwood PW Angus 2000 Right heart failure impairs hepatic elimination of p-nitrophenol without inducing changes in content or latency of hepatic UDP-glucuronosyltransferases J Pharmacol Exp Ther 295 2 830 835 11046125 1:CAS:528:DC%2BD3cXnsl2ktb8%3D
13. RA Baughman Jr S Arnold LZ Benet ET Lin K Chatterjee RL Williams 1980 Altered prazosin pharmacokinetics in congestive heart failure Eur J Clin Pharmacol 17 6 425 428 7398734 10.1007/BF00570159 1:CAS:528:DyaL3cXls1Sqs7g%3D
14. PW Angus CY Ng H Ghabrial DJ Morgan RA Smallwood 1995 Effects of chronic left ventricular failure on hepatic oxygenation and theophylline elimination in the rat Drug Metab Dispos 23 4 485 489 7600916 1:CAS:528:DyaK2MXltVGgu7w%3D
15. DP Jones 1981 Hypoxia and drug metabolism Biochem Pharmacol 30 10 1019 1023 7259789 10.1016/0006-2952(81)90436-6 1:CAS:528:DyaL3MXls1Wnu7o%3D
16. MH Hessel P Steendijk B den Adel CI Schutte A van der Laarse 2006 Characterization of right ventricular function after monocrotaline-induced pulmonary hypertension in the intact rat Am J Physiol 291 5 H2424 H2430 1:CAS:528:DC%2BD28Xht1Gnsb%2FJ
17. M Weiss C Stedtler MS Roberts 1997 On the validity of the dispersion model of hepatic drug elimination when intravascular transit time densities are long-tailed Bull Math Biol 59 5 911 929 9281905 10.1007/BF02459999 1:CAS:528:DyaK2sXlvFSjs7k%3D
18. M Weiss MS Roberts 1996 Tissue distribution kinetics as determinant of transit time dispersion of drugs in organs: application of a stochastic model to the rat hindlimb J Pharmacokinet Biopharm 24 2 173 196 8875346 10.1007/BF02353488 1:CAS:528:DyaK28XlvVKru7c%3D
19. MS Roberts 2010 Drug structure-transport relationships J Pharmacokinet Pharmacodyn 37 6 541 573 21107662 10.1007/s10928-010-9174-0 1:CAS:528: DC%2BC3cXhsF2gurjJ
20. E Pasini A Cargnioni F Pastore R Razzetti S Bongrani GL Gitti, et al. 2004 Effect of nolomirole on monocrotaline-induced heart failure Pharmacol Res 49 1 1 5 14597145 10.1016/S1043-6618(03)00246-9 1:CAS:528:DC%2BD3sXosVKltLs%3D
21. K Cheung PE Hickman JM Potter NI Walker M Jericho R Haslam, et al. 1996 An optimized model for rat liver perfusion studies J Surg Res 66 1 81 89 8954836 10.1006/jsre.1996.0376 1:CAS:528:DyaK2sXks12ntw%3D%3D
22. DY Hung P Chang M Weiss MS Roberts 2001 Structure-hepatic disposition relationships for cationic drugs in isolated perfused rat livers: transmembrane exchange and cytoplasmic binding process J Pharmacol Exp Ther 297 2 780 789 11303070 1:CAS:528:DC%2BD3MXjt1Wltrc%3D
23. MJ O'Brien NM Keating S Elderiny S Cerda AP Keaveny NH Afdhal, et al. 2000 An assessment of digital image analysis to measure fibrosis in liver biopsy specimens of patients with chronic hepatitis C Am J Clin Pathol 114 5 712 718 11068544 10.1309/D7AU-EYW7-4B6C-K08Y
24. T Matsubara M Koike A Touchi Y Tochino K Sugeno 1976 Quantitative determination of cytochrome P-450 in rat liver homogenate Anal Biochem 75 2 596 603 984414 10.1016/0003-2697(76)90114-7 1:CAS:528:DyaE28XltFymsb4%3D
25. M Weiss O Kuhlmann DY Hung MS Roberts 2000 Cytoplasmic binding and disposition kinetics of diclofenac in the isolated perfused rat liver Br J Pharmacol 130 6 1331 1338 10903973 10.1038/sj.bjp.0703448 1:CAS:528: DC%2BD3cXlsFOnsLc%3D
26. M Weiss 1999 Cellular pharmacokinetics: effects of cytoplasmic diffusion and binding on organ transit time distribution J Pharmacokinet Biopharm 27 3 233 256 10728488 10.1023/A:1020990912291 1:CAS:528:DC%2BD3cXitFaktL4%3D
27. B Joseph V Kumaran E Berishvili KK Bhargava CJ Palestro S Gupta 2006 Monocrotaline promotes transplanted cell engraftment and advances liver repopulation in rats via liver conditioning Hepatology 44 6 1411 1420 17133480 10.1002/hep.21416 1:CAS:528:DC%2BD2sXislKmtA%3D%3D
28. BL Copple RA Roth PE Ganey 2006 Anticoagulation and inhibition of nitric oxide synthase influence hepatic hypoxia after monocrotaline exposure Toxicology 225 2-3 128 137 16828949 10.1016/j.tox.2006.05.016 1:CAS:528: DC%2BD28Xns12ltLk%3D
29. H Nishi T Takahashi H Ichikawa G Matsumiya H Matsuda Y Sawa 2009 Prediction of postoperative hepatic dysfunction after cardiac surgery in patients with chronic congestive heart failure Gen Thorac Cardiovasc Surg 57 7 357 362 19597925 10.1007/s11748-008-0387-8
30. CY Ng PW Angus H Ghabrial ST Chou L Arnolda DJ Morgan, et al. 1995 Right heart failure impairs hepatic oxygenation and theophylline clearance in rats J Pharmacol Exp Ther 273 3 1332 1336 7791105 1:CAS:528:DyaK2MXmsVCgurg%3D
31. M Petersson B Rundqvist BM Bennett MA Adams P Friberg 2008 Impaired nitroglycerin biotransformation in patients with chronic heart failure Clin Physiol Funct Imaging 28 4 229 234 18384624 10.1111/j.1475-097X.2008.00793.x 1:CAS:528:DC%2BD1cXovFCitb8%3D
32. MS Roberts YG Anissimov 1999 Modeling of hepatic elimination and organ distribution kinetics with the extended convection-dispersion model J Pharmacokinet Biopharm 27 4 343 382 10826128 10.1023/A:1020992421184 1:CAS:528:DC%2BD3cXjtFSntLc%3D
33. MS Roberts M Rowland 1986 A dispersion model of hepatic elimination: 1. Formulation of the model and bolus considerations J Pharmacokinet Biopharm 14 3 227 260 3783446 10.1007/BF01106706 1:CAS:528:DyaL28XmtFyhtbk%3D
34. KS Pang M Rowland 1977 Hepatic clearance of drugs. I. Theoretical considerations of a "well-stirred" model and a "parallel tube" model. Influence of hepatic blood flow, plasma and blood cell binding, and the hepatocellular enzymatic activity on hepatic drug clearance J Pharmacokinet Biopharm 5 6 625 653 599411 10.1007/BF01059688 1:CAS:528:DyaE1cXhtFGjtLs%3D
35. D Catalano G Caruso S DiFazzio G Carpinteri N Scalisi GM Trovato 1998 Portal vein pulsatility ratio and heart failure J Clin Ultrasound 26 1 27 31 9475205 10.1002/(SICI)1097-0096(199801)26:1<27::AID-JCU6>3.0.CO;2-L 1:STN:280:DyaK1c7jtlemsA%3D%3D
36. MS Roberts X Liu Y Zou GA Siebert P Chang MW Whitehouse, et al. 2011 Effect of adjuvant-induced systemic inflammation in rats on hepatic disposition kinetics of taurocholate Am J Physiol Gastrointest Liver Physiol 300 1 G130 G136 21030608 10.1152/ajpgi.00162.2010 1:CAS:528:DC%2BC3MXhvVSjt78%3D
37. M Weiss P Li MS Roberts 2010 An improved nonlinear model describing the hepatic pharmacokinetics of digoxin: evidence for two functionally different uptake systems and saturable binding Pharm Res 27 9 1999 2007 20625800 10.1007/s11095-010-0204-9 1:CAS:528:DC%2BC3cXos1yqur4%3D
38. L Yan CA Hunt GE Ropella MS Roberts 2004 In silico representation of the liver-connecting function to anatomy, physiology and heterogeneous microenvironments Conf Proc IEEE Eng Med Biol Soc 2 853 856 17271811
39. S Park GE Ropella SH Kim MS Roberts CA Hunt 2009 Computational strategies unravel and trace how liver disease changes hepatic drug disposition J Pharmacol Exp Ther 328 1 294 305 18948498 10.1124/jpet.108.142497 1:CAS:528:DC%2BD1MXisFyrsQ%3D%3D
40. ZY Wu LP Rivory MS Roberts 1993 Physiological pharmacokinetics of solutes in the isolated perfused rat hindlimb: characterization of the physiology with changing perfusate flow, protein content, and temperature using statistical moment analysis J Pharmacokinet Biopharm 21 6 653 688 8138892 10.1007/BF01113500 1:CAS:528:DyaK2cXjtFGisL4%3D
41. P Singh MS Roberts 1993 Dermal and underlying tissue pharmacokinetics of salicylic acid after topical application J Pharmacokinet Biopharm 21 4 337 373 8133461 10.1007/BF01061687 1:CAS:528:DyaK2cXitlGgsr0%3D
42. MS Roberts MJ Roberts TA Robertson W Sanchez C Thorling Y Zou, et al. 2008 In vitro and in vivo imaging of xenobiotic transport in human skin and in the rat liver J Biophotonics 1 6 478 493 19343674 10.1002/jbio.200810058 1:CAS:528:DC%2BD1MXhsFKjt7w%3D
43. L Bass MS Roberts PJ Robinson 1987 On the relation between extended forms of the sinusoidal perfusion and of the convection-dispersion models of hepatic elimination J Theor Biol 126 4 457 482 3657241 10.1016/S0022-5193(87)80152-2 1:STN:280:DyaL1c%2Fht1Grtg%3D%3D
44. MS Roberts JD Donaldson M Rowland 1988 Models of hepatic elimination: comparison of stochastic models to describe residence time distributions and to predict the influence of drug distribution, enzyme heterogeneity, and systemic recycling on hepatic elimination J Pharmacokinet Biopharm 16 1 41 83 3373419 10.1007/BF01061862 1:CAS:528:DyaL1cXktlWnurw%3D
45. MS Roberts M Rowland 1986 A dispersion model of hepatic elimination: 3. Application to metabolite formation and elimination kinetics J Pharmacokinet Biopharm 14 3 289 308 3783448 10.1007/BF01106708 1:CAS:528:DyaL2sXht1alsg%3D%3D