2-Anilino-4-aryl-8H-purine derivatives as inhibitors of PDK1

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 8, 2012, Pages 2880-2884

  Blanchard, Stéphanie ^a   Soh, Chang Kai ^a   Lee, Chai Ping ^a   Poulsen, Anders ^a   Bonday, Zahid ^a   Goh, Kay Lin ^a   Goh, Kee Chuan ^a   Goh, Miah Kiat ^a   Pasha, Mohammed Khalid ^a   Wang, Haishan ^a   Williams, Meredith ^a   Wood, Jeanette M ^a   Ethirajulu, Kantharaj ^a   Dymock, Brian W ^a  

^a Singapore Science Park II   (Singapore)

Author keywords

3 Phosphoinositide dependent kinase 1 (PDK1); 4 Aryl purine; Akt; CDK2; PI3K

Indexed keywords

2 ANILINO 4 ARYL 8H PURINE DERIVATIVE; ANTINEOPLASTIC AGENT; PHOSPHOINOSITIDE DEPENDENT PROTEIN KINASE 1; PROTEIN KINASE B; PROTEIN SERINE THREONINE KINASE INHIBITOR; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ARTICLE; CANCER GROWTH; CANCER SURVIVAL; CARCINOGENESIS; CELL PROLIFERATION; CONTROLLED STUDY; DRUG ABSORPTION; DRUG ACTIVITY; DRUG BIOAVAILABILITY; DRUG DISTRIBUTION; DRUG EXCRETION; DRUG METABOLISM; DRUG SYNTHESIS; HUMAN; HUMAN CELL; MOUSE; NONHUMAN; SIGNAL TRANSDUCTION; STRUCTURE ACTIVITY RELATION;

ANILINE COMPOUNDS; ANIMALS; CELL LINE, TUMOR; CELLS, CULTURED; ENZYME ACTIVATION; ENZYME INHIBITORS; HUMANS; INHIBITORY CONCENTRATION 50; MICE; MOLECULAR STRUCTURE; PROTEIN-SERINE-THREONINE KINASES; PURINES; SMALL MOLECULE LIBRARIES; SOLUBILITY;

MUS;

EID: 84862794165     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.02.058     Document Type: Article

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