Node/Aorta and Node/Liver SUV Ratios from 18F-FDG PET/CT May Improve the Detection of Occult Mediastinal Lymph Node Metastases in Patients with Non-Small Cell Lung Carcinoma

Academic Radiology

Volumn 19, Issue 6, 2012, Pages 685-692

  Kuo, Wen Han ^a   Wu, Yi Cheng ^a   Wu, Ching Yang ^a   Ho, Kung Chu ^a   Chiu, Pin Hsiu ^a   Wang, Chih Wei ^a   Chang, Chee Jen ^a   Yu, Chih Teng ^a   Yen, Tzu Chen ^a   Lin, Chieh ^a  

^a CHANG GUNG UNIVERSITY COLLEGE OF MEDICINE   (Taiwan)

Author keywords

Mediastinal lymph node; Node aorta SUV ratio; Node liver SUV ratio; Non small cell lung cancer; Positron emission tomography

Indexed keywords

FLUORODEOXYGLUCOSE F 18;

ADULT; AGED; AORTA; ARTICLE; CANCER DIAGNOSIS; CANCER STAGING; COMPUTED TOMOGRAPHY SCANNER; COMPUTER ASSISTED TOMOGRAPHY; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; FALSE NEGATIVE RESULT; FEMALE; HISTOPATHOLOGY; HUMAN; HUMAN TISSUE; LIVER; LUNG NON SMALL CELL CANCER; LYMPH NODE DISSECTION; LYMPH NODE METASTASIS; MAJOR CLINICAL STUDY; MALE; MEDIASTINUM LYMPH NODE; OCCULT CANCER; POSITRON EMISSION TOMOGRAPHY; PRIORITY JOURNAL; RADIOLOGICAL PARAMETERS; REFERENCE VALUE; SENSITIVITY AND SPECIFICITY; STANDARDIZED UPTAKE VALUE;

ADULT; AGED; AGED, 80 AND OVER; AORTA; AORTOGRAPHY; CARCINOMA, NON-SMALL-CELL LUNG; FEMALE; FLUORODEOXYGLUCOSE F18; HUMANS; LIVER; LUNG NEOPLASMS; LYMPH NODES; LYMPHATIC METASTASIS; MALE; MEDIASTINUM; MIDDLE AGED; POSITRON-EMISSION TOMOGRAPHY; RADIOPHARMACEUTICALS; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; TOMOGRAPHY, X-RAY COMPUTED;

EID: 84862792714     PISSN: 10766332     EISSN: 18784046     Source Type: Journal    
DOI: 10.1016/j.acra.2012.02.013     Document Type: Article

References (24)

1. Jemal A., Siegel R., Xu J., et al. Cancer statistics, 2010. CA Cancer J Clin 2010, 60:277-300.
2. Detterbeck F.C., Boffa D.J., Tanoue L.T. The new lung cancer staging system. Chest 2009, 136:260-271.
3. Ettinger D.S., Akerley W., Bepler G., et al. Non-small cell lung cancer. J Natl Compr Canc Netw 2010, 8:740-801.
4. Beggs A.D., Hain S.F., Curran K.M., et al. FDG-PET as a "metabolic biopsy" tool in non-lung lesions with indeterminate biopsy. Eur J Nucl Med Mol Imaging 2002, 29:542-546.
5. Pieterman R.M., van Putten J.W., Meuzelaar J.J., et al. Preoperative staging of non-small-cell lung cancer with positron-emission tomography. N Engl J Med 2000, 343:254-261.
6. 18Fluorodeoxyglucose positron emission tomography in the diagnosis and staging of lung cancer: a systematic review. J Natl Cancer Inst 2007, 99:1753-1767.
7. Whitson B.A., Groth S.S., Maddaus M.A. Recommendations for optimal use of imaging studies to clinically stage mediastinal lymph nodes in non-small-cell lung cancer patients. Lung Cancer 2008, 61:177-185.
8. Takamochi K., Yoshida J., Murakami K., et al. Pitfalls in lymph node staging with positron emission tomography in non-small cell lung cancer patients. Lung Cancer 2005, 47:235-242.
9. Vesselle H., Pugsley J.M., Vallieres E., et al. The impact of fluorodeoxyglucose F 18 positron-emission tomography on the surgical staging of non-small cell lung cancer. J Thorac Cardiovasc Surg 2002, 124:511-519.
10. Reed C.E., Harpole D.H., Posther K.E., et al. Results of the American College of Surgeons Oncology Group Z0050 trial: the utility of positron emission tomography in staging potentially operable non-small cell lung cancer. J Thorac Cardiovasc Surg 2003, 126:1943-1951.
11. Pozo-Rodriguez F., Martin de Nicolas J.L., Sanchez-Nistal M.A., et al. Accuracy of helical computed tomography and [18F] fluorodeoxyglucose positron emission tomography for identifying lymph node mediastinal metastases in potentially resectable non-small-cell lung cancer. J Clin Oncol 2005, 23:8348-8356.
12. Bille A., Pelosi E., Skanjeti A., et al. Preoperative intrathoracic lymph node staging in patients with non-small-cell lung cancer: accuracy of integrated positron emission tomography and computed tomography. Eur J Cardiothorac Surg 2009, 36:440-445.
13. Shim S.S., Lee K.S., Kim B.T., et al. Non-small cell lung cancer: prospective comparison of integrated FDG PET/CT and CT alone for preoperative staging. Radiology 2005, 236:1011-1019.
14. Hellwig D., Graeter T.P., Ukena D., et al. 18F-FDG PET for mediastinal staging of lung cancer: which SUV threshold makes sense?. J Nucl Med 2007, 48:1761-1766.
15. Bryant A.S., Cerfolio R.J., Klemm K.M., et al. Maximum standard uptake value of mediastinal lymph nodes on integrated FDG-PET-CT predicts pathology in patients with non-small cell lung cancer. Ann Thorac Surg 2006, 82:417-422.
16. Cerfolio R.J., Ojha B., Bryant A.S., et al. The accuracy of integrated PET-CT compared with dedicated PET alone for the staging of patients with nonsmall cell lung cancer. Ann Thorac Surg 2004, 78:1017-1023.
17. Melek H., Gunluoglu M.Z., Demir A., et al. Role of positron emission tomography in mediastinal lymphatic staging of non-small cell lung cancer. Eur J Cardiothorac Surg 2008, 33:294-299.
18. Hwangbo B., Kim S.K., Lee H.S., et al. Application of endobronchial ultrasound-guided transbronchial needle aspiration following integrated PET/CT in mediastinal staging of potentially operable non-small cell lung cancer. Chest 2009, 135:1280-1287.
19. Saydam O, Gokce M, Kilicgun A, et al. Accuracy of positron emission tomography in mediastinal node assessment in coal workers with lung cancer. Med Oncol. In press.
20. Tournoy K.G., Maddens S., Gosselin R., et al. Integrated FDG-PET/CT does not make invasive staging of the intrathoracic lymph nodes in non-small cell lung cancer redundant: a prospective study. Thorax 2007, 62:696-701.
21. Cheng N.M., Yu C.T., Ho K.C., et al. Respiration-averaged CT for attenuation correction in non-small-cell lung cancer. Eur J Nucl Med Mol Imaging 2009, 36:607-615.
22. Karam M., Roberts-Klein S., Shet N., et al. Bilateral hilar foci on 18F-FDG PET scan in patients without lung cancer: variables associated with benign and malignant etiology. J Nucl Med 2008, 49:1429-1436.
23. Lardinois D., De Leyn P., Van Schil P., et al. ESTS guidelines for intraoperative lymph node staging in non-small cell lung cancer. Eur J Cardiothorac Surg 2006, 30:787-792.
24. Kong F.M., Frey K.A., Quint L.E., et al. A pilot study of [18F]fluorodeoxyglucose positron emission tomography scans during and after radiation-based therapy in patients with non small-cell lung cancer. J Clin Oncol 2007, 25:3116-3123.