Synthesis and antidiabetic performance of β-amino ketone containing nabumetone moiety

Bioorganic and Medicinal Chemistry

Volumn 20, Issue 6, 2012, Pages 2119-2130

  Wang, Hang ^a   Yan, Ju Fang ^b   Song, Xiao Li ^a   Fan, Li ^a   Xu, Jin ^a   Zhou, Guang Ming ^a   Jiang, Li ^c   Yang, Da Cheng ^a  

^a SOUTHWEST UNIVERSITY   (China)

^b Chengdu di Ao Pharmaceutical Group Co Ltd   (China)

^c SCHLUMBERGER   (United States)

Author keywords

Glucosidase; Amino ketone; Diabetes mellitus; Mannich reaction; Nabumetone; Peroxisome proliferator activated receptor

Indexed keywords

1 (2,4 DICHLOROPHENYL) 5 (6 METHOXYNAPHTHALEN 2 YL) 1 (5 METHYLISOXAZOL 3 YLAMINO)PENTAN 3 ONE; 1 (3 CHLOROPHENYL) 5 (6 METHOXYNAPHTHALEN 2 YL) 1 (5 METHYLISOXAZOL 3 YLAMINO)PENTAN 3 ONE; 1 (3 FLUOROPHENYL) 5 (6 METHOXYNAPHTHALEN 2 YL) 1 (5 METHYLISOXAZOL 3 YLAMINO)PENTAN 3 ONE; 1 (3,4 DICHLOROPHENYL) 5 (6 METHOXYNAPHTHALEN 2 YL) 1 (5 METHYLISOXAZOL 3 YLAMINO)PENTAN 3 ONE; 1 (4 BROMOPHENYL) 5 (6 METHOXYNAPHTHALEN 2 YL) 1 (5 METHYLISOXAZOL 3 YLAMINO)PENTAN 3 ONE; 1 (4 BUTOXYPHENYL) 5 (6 METHOXYNAPHTHALEN 2 YL) 1 (5 METHYLISOXAZOL 3 YLAMINO)PENTAN 3 ONE; 1 (4 CHLOROPHENYL) 5 (6 METHOXYNAPHTHALEN 2 YL) 1 (5 METHYLISOXAZOL 3 YLAMINO)PENTAN 3 ONE; 1 (4 HYDROXYPHENYL) 5 (6 METHOXYNAPHTHALEN 2 YL) 1 (5 METHYLISOXAZOL 3 YLAMINO)PENTAN 3 ONE; 1 (BENZO[D][1,3]DIOXOL 5 YL) 5 (6 METHOXYNAPHTHALEN 2 YL) 1 (5 METHYLISOXAZOL 3 YLAMINO)PENTAN 3 ONE; 4 [1 (3 CHLOROPHENYL) 5 (6 METHOXYNAPHTHALEN 2 YL) 3 OXOPENTYLAMINO]BENZENESULFONAMIDE; 4 [1 (3 FLUOROPHENYL) 5 (6 METHOXYNAPHTHALEN 2 YL) 3 OXOPENTYLAMINO]BENZENESULFONAMIDE; 4 [1 (3,4 DICHLOROPHENYL) 5 (6 METHOXYNAPHTHALEN 2 YL) 3 OXOPENTYLAMINO]BENZENESULFONAMIDE; 4 [1 (4 BROMOPHENYL) 5 (6 METHOXYNAPHTHALEN 2 YL) 3 OXOPENTYLAMINO]BENZENESULFONAMIDE; 4 [1 (4 CHLOROPHENYL) 5 (6 METHOXYNAPHTHALEN 2 YL) 3 OXOPENTYLAMINO]BENZENESULFONAMIDE; 4 [5 (6 METHOXYNAPHTHALEN 2 YL) 1 (3 METHOXYPHENYL) 3 OXOPENTYLAMINO]BENZENESULFONAMIDE; 4 [5 (6 METHOXYNAPHTHALEN 2 YL) 1 (3 NITROPHENYL) 3 OXOPENTYLAMINO]BENZENESULFONAMIDE; 4 [5 (6 METHOXYNAPHTHALEN 2 YL) 1 (4 NITROPHENYL) 3 OXOPENTYLAMINO]BENZENESULFONAMIDE; 4 [5 (6 METHOXYNAPHTHALEN 2 YL) 3 OXO 1 PHENYLPENTYLAMINO]BENZENESULFONAMIDE; 5 (6 METHOXYNAPHTHALEN 2 YL) 1 (3 METHOXYPHENYL) 1 (5 METHYLISOXAZOL 3 YLAMINO)PENTAN 3 ONE; 5 (6 METHOXYNAPHTHALEN 2 YL) 1 (4 METHOXYPHENYL) 1 (5 METHYLISOXAZOL 3 YLAMINO)PENTAN 3 ONE; 5 (6 METHOXYNAPHTHALEN 2 YL) 1 (5 METHYLISOXAZOL 3 YLAMINO) 1 (3 NITROPHENYL)PENTAN 3 ONE; 5 (6 METHOXYNAPHTHALEN 2 YL) 1 (5 METHYLISOXAZOL 3 YLAMINO) 1 (4 NITROPHENYL)PENTAN 3 ONE; 5 (6 METHOXYNAPHTHALEN 2 YL) 1 (5 METHYLISOXAZOL 3 YLAMINO) 1 M TOLYLPENTAN 3 ONE; 5 (6 METHOXYNAPHTHALEN 2 YL) 1 (5 METHYLISOXAZOL 3 YLAMINO) 1 P TOLYLPENTAN 3 ONE; 5 (6 METHOXYNAPHTHALEN 2 YL) 1 (5 METHYLISOXAZOL 3 YLAMINO)1 PHENYLPENTAN 3 ONE; ALPHA GLUCOSIDASE; NABUMETONE; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR; SULFANILAMIDE; UNCLASSIFIED DRUG; UNINDEXED DRUG;

ANTIDIABETIC ACTIVITY; ARTICLE; CARBON NUCLEAR MAGNETIC RESONANCE; CONTROLLED STUDY; DRUG DESIGN; DRUG STRUCTURE; DRUG SYNTHESIS; DRUG TARGETING; ELECTROSPRAY MASS SPECTROMETRY; ENZYME ACTIVITY; ENZYME INHIBITION; IN VITRO STUDY; PROTON NUCLEAR MAGNETIC RESONANCE; STRUCTURE ACTIVITY RELATION;

ALPHA-GLUCOSIDASES; AMINES; BUTANONES; DIABETES MELLITUS; HUMANS; HYPOGLYCEMIC AGENTS; KETONES; MAGNETIC RESONANCE SPECTROSCOPY; MODELS, MOLECULAR; PEROXISOME PROLIFERATOR-ACTIVATED RECEPTORS; STRUCTURE-ACTIVITY RELATIONSHIP; SULFANILAMIDES;

EID: 84862787230     PISSN: 09680896     EISSN: 14643391     Source Type: Journal    
DOI: 10.1016/j.bmc.2012.01.028     Document Type: Article

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