A combination of metabolomics and metallomics studies of urine and serum from hypercholesterolaemic rats after berberine injection

Analytical and Bioanalytical Chemistry

Volumn 403, Issue 3, 2012, Pages 847-856

  Liu, Feng ^a   Gan, Pei Pei ^a   Wu, Huanan ^a   Woo, Wei Shan ^a   Ong, Eng Shi ^a   Li, Sam Fong Yau ^a  

^a NATIONAL UNIVERSITY OF SINGAPORE   (Singapore)

Author keywords

1H NMR; Berberine; ICP MS; Metabolomics; Metallomics

Indexed keywords

ANIMAL MODEL; BERBERINE; BIOCHEMICAL PROCESS; CHOLESTEROL METABOLISM; CONTROL GROUPS; DRUG EFFICACY; ICP-MS; KREBS CYCLE; METABOLIC FINGERPRINTING; METABOLIC PROCESS; METABOLOMICS; METALLOMICS; PROTON NUCLEAR MAGNETIC RESONANCE; RAT BLOOD; RAT MODEL; RAT URINE; URINARY TRACT INFECTIONS; URINE AND SERUM; WESTERN COUNTRIES;

BIOCHEMISTRY; BODY FLUIDS; INDUCTIVELY COUPLED PLASMA MASS SPECTROMETRY; MANGANESE; METABOLISM; SODIUM;

RATS;

BERBERINE; METAL;

ANIMAL; BLOOD; CHEMISTRY; CONFERENCE PAPER; COPTIS; DRUG EFFECT; HYPERCHOLESTEROLEMIA; MASS SPECTROMETRY; METABOLISM; METABOLOME; METABOLOMICS; METHODOLOGY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; RAT; SPRAGUE DAWLEY RAT; URINE;

ANIMALS; BERBERINE; COPTIS; HYPERCHOLESTEROLEMIA; MAGNETIC RESONANCE SPECTROSCOPY; MASS SPECTROMETRY; METABOLOME; METABOLOMICS; METALS; RATS; RATS, SPRAGUE-DAWLEY;

ANIMALIA; RATTUS;

EID: 84862781804     PISSN: 16182642     EISSN: 16182650     Source Type: Journal    
DOI: 10.1007/s00216-012-5923-9     Document Type: Conference Paper

References (38)

1. Yin J, Xing H, Ye J (2008) Efficacy of berberine in patients with type 2 diabetes mellitus. Metab Clin Exp 57(5):712-717 (Pubitemid 351608234)
2. Leng SH, Lu FE, Xu LJ (2004) Therapeutic effects of berberine in impaired glucose tolerance rats and its influence on insulin secretion. Acta Pharmacol Sin 25(4):496-502
3. Wang HX, Ng TB (1999) Natural products with hypoglycemic, hypotensive, hypocholesterolemic, antiatherosclerotic and antithrombotic activities. Life Sci 65(25):2663-2677
4. Lee YS, Kim WS, Kim KH, Yoon MJ, Cho HJ, Shen Y, Ye JM, Lee CH, Oh WK, Kim CT, Hohnen-Behrens C, Gosby A, Kraegen EW, James DE, Kim JB (2006) Berberine, a natural plant product, activates AMP-activated protein kinase with beneficial metabolic effects in diabetic and insulin-resistant states. Diabetes 55(8):2256-2264 (Pubitemid 44743622)
5. Nicholson JK, Lindon JC, Holmes E (1999) 'Metabonomics': understanding the metabolic responses of living systems to pathophysiological stimuli via multivariate statistical analysis of biological NMR spectroscopic data. Xenobiotica 29(11):1181-1189
6. Wu H, Xue R, Tang Z, Deng C, Liu T, Zeng H, Sun Y, Shen X (2010) Metabolomic investigation of gastric cancer tissue using gas chromatography/mass spectrometry. Anal Bioanal Chem 396(4):1385-1395
7. Dunn WB, Ellis DI (2005) Metabolomics: current analytical platforms and methodologies. TrAC Trends Anal Chem 24(4):285-294 (Pubitemid 40461029)
8. Pan Z, Raftery D (2007) Comparing and combining NMR spectroscopy and mass spectrometry in metabolomics. Anal Bioanal Chem 387(2):525-527 (Pubitemid 46067468)
9. Nicholson JK, Connelly J, Lindon JC, Holmes E (2002) Metabonomics: a platform for studying drug toxicity and gene function. Nat Rev Drug Discov 1(2):153-161 (Pubitemid 41646523)
10. Robertson DG, Reily MD, Baker JD (2007) Metabonomics in pharmaceutical discovery and development. J Proteome Res 6(2):526-539 (Pubitemid 46340156)
11. Keun HC (2006) Metabonomic modeling of drug toxicity. Pharmacol Ther 109(1-2):92-106 (Pubitemid 41740817)
12. 31P NMR studies with D-serine in rat urine and kidney, time-and dose-related metabolic effects. Chem Res Toxicol 16(10):1207-1216 (Pubitemid 37315210)
13. Bollard ME, Keun HC, Beckonert O, Ebbels T M D, Antti H, Nicholls AW, Shockcor JP, Cantor GH, Stevens G, Lindon JC, Holmes E, Nicholson JK (2005) Comparative metabonomics of differential hydrazine toxicity in the rat and mouse. Toxicol Appl Pharmacol 204(2):135-151 (Pubitemid 40432371)
14. Waters NJ, Waterfield CJ, Farrant RD, Holmes E, Nicholson JK (2006) Integrated metabonomic analysis of bromobenzene-induced hepatotoxicity: novel induction of 5-oxoprolinosis. J Proteome Res 5(6):1448-1459 (Pubitemid 43865813)
15. Gu H, Chen H, Pan Z, Jackson AU, Talaty N, Xi B, Kissinger C, Duda C, Mann D, Raftery D, Cooks RG (2007) Monitoring diet effects via biofluids and their implications for metabolomics studies. Anal Chem 79(1):89-97 (Pubitemid 46095034)
16. Yamamoto H, Yamaji H, Abe Y, Harada K, Waluyo D, Fukusaki E, Kondo A, Ohno H, Fukuda H (2009) Dimensionality reduction for metabolome data using PCA, PLS, OPLS, and RFDA with differential penalties to latent variables. Chemom Intell Lab Syst 98(2):136-142
17. Haraguchi H (2004) Metallomics as integrated biometal science. J Anal At Spectrom 19(1):5-14
18. Szpunar J (2005) Advances in analytical methodology for bioinorganic speciation analysis: metallomics, metalloproteomics and heteroatom-tagged proteomics and metabolomics. Analyst 130(4):442-465 (Pubitemid 40523241)
19. Riondato J, Vanhaecke F, Moens L, Dams R (1997) Determination of trace and ultratrace elements in human serum with a double focusing magnetic sector inductively coupled plasma mass spectrometer. J Anal At Spectrom 12(9):933-937 (Pubitemid 127589805)
20. http://sis.nlm.nih.gov/index.html. Accessed 11 Mar. 2011
21. -1 NMR-based metabonomics for the diagnosis of inborn errors of metabolism in urine. Anal Chim Acta 542(2):169-177. doi:10.1016/j.aca.2005.03.059 (Pubitemid 40804514)
22. Craig A, Cloarec O, Holmes E, Nicholson JK, Lindon JC (2006) Scaling and normalization effects in NMR spectroscopic metabonomic data sets. Anal Chem 78(7):2262-2267
23. Waters NJ, Holmes E, Williams A, Waterfield CJ, Duncan Farrant R, Nicholson JK (2001) NMR and pattern recognition studies on the time-related metabolic effects of a-naphthylisothiocyanate on liver, urine, and plasma in the rat: an integrative metabonomic approach. Chem Res Toxicol 14(10):1401-1412 (Pubitemid 32983265)
24. Warrack BM, Hnatyshyn S, Ott KH, Reily MD, Sanders M, Zhang HY, Drexler DM (2009) Normalization strategies for metabonomic analysis of urine samples. J Chromatogr B 877(5-6):547-552. doi:10.1016/j.jchromb.2009.01.007
25. Szpunar J (2004) Metallomics: a new frontier in analytical chemistry. Anal Bioanal Chem 378(1):54-56 (Pubitemid 40877796)
26. 1H NMR metabolomics reveals extensive metabolic reprogramming of primary and secondary metabolism in elicitor-treated opium poppy cell cultures. BMC Plant Biol 8(5):10.1186/1471-2229-8-5 (Pubitemid 351327252)
27. http://www.sciencedaily.com/articles/k/ketone-bodies.htm. Accessed 6 Feb. 2011
28. http://science.jrank.org/pages/3776/Krebs-Cycle.html. Accessed 21 Dec. 2010
29. http://hyperphysics.phy-astr.gsu.edu/hbase/biology/nakpump. html. Accessed 21 Feb. 2011
30. http://www.articlealley.com/article-657739-23.html. Accessed 7 Feb. 2011
31. Sakurai H (2002) A new concept: the use of vanadium complexes in the treatment of diabetes mellitus. Chem Rec 2(4):237-248. doi:10.1002/tcr.10029 (Pubitemid 44133929)
32. Nielsen FH (2000) Importance of making dietary recommendations for elements designated as nutritionally beneficial, pharmacologically beneficial, or conditionally essential. J Trace Elem Exp Med 13(1):113-129 (Pubitemid 30088424)
33. Willsky GR, Goldfine AB, Kostyniak PJ, McNeill JH, Yang LQ, Khan HR, Crans DC (2001) Effect of vanadium (IV) compounds in the treatment of diabetes: in vivo and in vitro studies with vanadyl sulfate and bis (maltolato) oxovandium (IV). J Inorg Biochem 85(1):33-42 (Pubitemid 32506793)
34. Verma S, Cam MC, McNeill JH (1998) Nutritional factors that can favorably influence the glucose/insulin system: vanadium. J Am Coll Nutr 17(1):11-18 (Pubitemid 28081135)
35. Bhattacharyya S, Tracey AS (2001) Vanadium (V) complexes in enzyme systems: aqueous chemistry, inhibition and molecular modeling in inhibitor design. J Inorg Biochem 85(1):9-13 (Pubitemid 32506791)
36. Legleiter LR, Spears JW, Lloyd KE (2005) Influence of dietary manganese on performance, lipid metabolism, and carcass composition of growing and finishing steers. J Anim Sci 83(10):2434-2439
37. Ko BS, Choi SB, Park SK, Jang JS, Kim YE, Park S (2005) Insulin sensitizing and insulinotropic action of berberine from Cortidis rhizoma. Biol Pharm Bull 28(8):1431-1437 (Pubitemid 41379694)
38. http://www.execulink.com/~ekimmel/central/na-k.htm. Accessed 7 Feb. 2011