Characterization of germline antibody libraries from human umbilical cord blood and selection of monoclonal antibodies to viral envelope glycoproteins: Implications for mechanisms of immune evasion and design of vaccine immunogens

Biochemical and Biophysical Research Communications

Volumn 417, Issue 4, 2012, Pages 1164-1169

  Chen, Weizao ^a   Streaker, Emily D ^a,b   Russ, Daniel E ^c   Feng, Yang ^a   Prabakaran, Ponraj ^a,b   Dimitrov, Dimiter S ^a  

^a NATIONAL CANCER INSTITUTE   (United States)

^b SAIC FREDERICK INC   (United States)

^c NATIONAL INSTITUTES OF HEALTH   (United States)

Author keywords

Envelope glycoprotein; Gp120; HIV 1; Human monoclonal antibody; IgM; Immunogen

Indexed keywords

GUANINE NUCLEOTIDE BINDING PROTEIN; HUMAN IMMUNODEFICIENCY VIRUS ANTIBODY; IMMUNOGLOBULIN M ANTIBODY; MONOCLONAL ANTIBODY; NEUTRALIZING ANTIBODY; VACCINE; VIRUS ENVELOPE PROTEIN; VIRUS GLYCOPROTEIN;

AMINO ACID SEQUENCE; ANTIBODY LIBRARY; ANTIBODY SPECIFICITY; ANTIGEN BINDING; ARTICLE; BINDING AFFINITY; GERM LINE; HENDRA VIRUS; HUMAN; HUMAN IMMUNODEFICIENCY VIRUS 1; HUMAN TISSUE; IMMUNE EVASION; IMMUNE RESPONSE; NONHUMAN; PRIORITY JOURNAL; PROTEIN BINDING; PROTEIN DOMAIN; RECEPTOR BINDING; SARS CORONAVIRUS; SOMATIC HYPERMUTATION; UMBILICAL CORD BLOOD; VIROPHAGE;

ADAPTIVE IMMUNITY; AMINO ACID SEQUENCE; ANTIBODIES, MONOCLONAL; ANTIBODIES, NEUTRALIZING; FETAL BLOOD; GLYCOPROTEINS; HENDRA VIRUS; HIV-1; HUMANS; MOLECULAR SEQUENCE DATA; PEPTIDE LIBRARY; PROTEIN STRUCTURE, TERTIARY; SARS VIRUS; VIRAL ENVELOPE PROTEINS;

HENDRA VIRUS; HUMAN IMMUNODEFICIENCY VIRUS 1; NIPAH VIRUS; SARS CORONAVIRUS;

EID: 84862777880     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2011.12.089     Document Type: Article

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