Discovery of a new class of ghrelin receptor antagonists

Bioorganic and Medicinal Chemistry Letters

Volumn 22, Issue 5, 2012, Pages 2046-2051

  Mihalic, Jeffrey T ^a   Kim, Yong Jae ^a   Lizarzaburu, Mike ^a   Deignan, Jeff ^a   Wanska, Malgorzata ^a   Yu, Ming ^a   Fu, Jiasheng ^a   Chen, Xi ^a   Zhang, Alex ^a   Connors, Richard ^a   Liang, Lingming ^a   Lindstrom, Michelle ^a   Ma, Ji ^a   Tang, Liang ^a   Dai, Kang ^a   Li, Leping ^a   Chen, Xiaoqi ^a  

^a AMGEN INC   (United States)

Author keywords

Ghrelin; GHSR1a; Obesity

Indexed keywords

AEQUORIN; CALCIUM ION; GHRELIN RECEPTOR ANTAGONIST; PEPTIDE HORMONE RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ARTICLE; ASSAY; CALCIUM CELL LEVEL; DRUG ANTAGONISM; DRUG DETERMINATION; DRUG POTENCY; DRUG STABILITY; DRUG STRUCTURE; DRUG SYNTHESIS; IN VITRO STUDY; LIVER CELL;

ANIMALS; BENZODIAZEPINES; CALCIUM; CELL LINE; HEPATOCYTES; HUMANS; LUMINESCENT MEASUREMENTS; OBESITY; RATS; RATS, SPRAGUE-DAWLEY; RECEPTORS, GHRELIN; STRUCTURE-ACTIVITY RELATIONSHIP;

RATTUS;

EID: 84862777459     PISSN: 0960894X     EISSN: 14643405     Source Type: Journal    
DOI: 10.1016/j.bmcl.2012.01.014     Document Type: Article

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