Antioxidant treatment reduces blast-induced cochlear damage and hearing loss

Hearing Research

Volumn 285, Issue 1-2, 2012, Pages 29-39

  Ewert, Donald L ^a   Lu, Jianzhong ^a   Li, Wei ^a   Du, Xiaoping ^a   Floyd, Robert ^b   Kopke, Richard ^a,b,c  

^a HOUGH EAR INSTITUTE   (United States)

^b OKLAHOMA MEDICAL RESEARCH FOUNDATION   (United States)

^c UNIVERSITY OF OKLAHOMA COLLEGE OF MEDICINE   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

2,4 DISULFONYL ALPHA PHENYL TERTIARY BUTYL NITRONE; ACETYLCYSTEINE; ANTIOXIDANT; UNCLASSIFIED DRUG;

ANIMAL CELL; ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ANTIOXIDANT ACTIVITY; ARTICLE; AUDITORY STIMULATION; AUDITORY THRESHOLD; BASILAR MEMBRANE; CELL ASSAY; CELL LOSS; CELLULAR DISTRIBUTION; COCHLEA INJURY; CONTROLLED STUDY; DISTORTION PRODUCT OTOACOUSTIC EMISSION; DRUG EFFECT; EVOKED BRAIN STEM AUDITORY RESPONSE; HAIR CELL; HEARING LOSS; HISTOPATHOLOGY; MALE; NONHUMAN; OPEN FIELD TEST; PHYSIOLOGICAL PROCESS; PRIORITY JOURNAL; RAT; REPRODUCIBILITY;

ACETYLCYSTEINE; ANIMALS; ANTIOXIDANTS; AUDITORY THRESHOLD; BENZENESULFONATES; COCHLEA; DISEASE MODELS, ANIMAL; DRUG THERAPY, COMBINATION; EVOKED POTENTIALS, AUDITORY, BRAIN STEM; HAIR CELLS, AUDITORY, INNER; HAIR CELLS, AUDITORY, OUTER; HEARING LOSS, NOISE-INDUCED; MALE; OTOACOUSTIC EMISSIONS, SPONTANEOUS; RATS; RATS, LONG-EVANS; TIME FACTORS;

EID: 84862776913     PISSN: 03785955     EISSN: 18785891     Source Type: Journal    
DOI: 10.1016/j.heares.2012.01.013     Document Type: Article

References (40)

1. Abi-Hacehm R.N., Sine Z., Van De Water T.R. The injured cochlea as a target for inflammatory processes, initiation of cell death pathways and application of related otoprotective strategies. Recent Patents CNS Drug Discov. 2010, 5:147-163.
2. Cave K.M., Cornish E.M., Chandler D.W. Blast injury of the ear: clinical update from the global war on terror. Mil Med. 2007, 172:726-730.
3. Cernak I., Noble-Haeusslein L.J. Traumatic brain injury: an overview of pathobiology with emphasis on military populations. J. Cereb. Blood Flow Metab. 2010, 30:255-266.
4. Chavko M., Adeeb S., Ahlers S.T., McCarron R.M. Attenuation of pulmonary inflammation after exposure to blast overpressure by N-acetylcysteine amide. Shock 2009, 32:325-331.
5. Chen G., Shi J., Hu Z., Hang C. Inhibitory effect on cerebral inflammatory response following traumatic brain injury in rats: a potential neuroprotective mechanism of N-acetylcysteine. Mediators Inflamm. 2008, 1-8.
6. Cheng J., Gu J., Ma Y., Yang T., Kuang Y., Li B., Kang J. Development of a rat model for studying blast-induced traumatic brain injury. J. Neurol. Sci. 2010, 294:23-28.
7. Choi C.H., Chen K., Vasquez-Weldon A., Jackson R.L., Floyd R.A., Kopke R.D. Effectiveness of 4-hydroxy phenyl N-tert-butylnitrone (4-OHPBN) alone and in combination with other antioxidant drugs in the treatment of acute acoustic trauma in chinchilla. Free Radic. Biol. Med. 2008, 44:1772-1784.
8. Clausen F., Marklund N., Lewe'n A., Hillered L. The tirone free radical scavenger NXY-059 is neuroprotective when administered after traumatic brain injury in the rat. J. Neurotrauma 2008, 25:1449-1457.
9. Elsayed N.M., Gorbunov N.V. Interplay between high energy impulse noise (blast) and antioxidants in the lung. Toxicology 2003, 189:63-74.
10. Elsayed N.M., Armstrong K.L., William M.T., Cooper M.F. Antioxidant loading reduces oxidative stress induced by high-energy impulse noise (blast) exposure. Toxicology 2000, 155:91-99.
11. Fausti S.A., Wilmington D.J., Gallun F.J., Myers P.J., Henry J.A. Auditory and vestibular dysfunction associated with blast-related traumatic brain injury. J. Rehabil. R. D. 2009, 46:797-810.
12. Floyd R.A., Kopke R.D., Choi C.-H., Foster S.B., Doblas S., Towner R.A. Nitrones as therapeutics. Free Radic. Biol. Med. 2008, 15:1361-1374.
13. Garth R.J.N. Blast injury of the auditory system: a review of the mechanisms and pathology. J. Laryngol. Otology 1994, 108:925-929.
14. Gondusky J.S., Reiter M.P. Protecting military convoys in Iraq: an examination of battle injuries sustained by a mechanized battalion during Operation Iraqi Freedom II. Mil. Md. 2005, 170:546-549.
15. Haase G.M., Prasad K.N., Cole W.C., Baggett-Strehlau J.M., Wyatt S.E. Antioxidant micronutrient impact on hearing disorders: concept, rationale, and evidence. Am. J. Otol. 2011, 32:55-61.
16. Hamernik R.P. The effect of impulse intensity and the number of impulses on hearing and cochlear pathology in the chinchilla. J. Acoust. Soc. Am. 1987, 81:1118-1129.
17. Hamernik R.P., Ahroon W.A., Hsueh K.D. The energy spectrum of an impulse: its relation to hearing loss. J. Acoust. Soc. Am. 1991, 90:197-204.
18. Henderson D., Bielefeld E.C., Harris K.C., Hu B.H. The role of oxidative stress in noise-induced hearing loss. Ear Hear 2006, 27:1-19.
19. Henry W.R., Mulroy M.J. Afferent synaptic changes in auditory hair cells during noise-induced temporary threshold shift. Hearing Res. 1995, 84:81-90.
20. Hoffer M.E., Balaban C.D. Neurotologic Consequences of Blast Injury 2010, International Brain Injury Association, NeuroTrauma Letter 05. http://www.internationalbrain.org/%3fq%3Dnode/151.
21. Jaffin J.H., McKinney L., Kinney RC., Cunningham J.A., Moritz D.M., Krimer J.M., Graeber G.M., Moe J.B., Salander J.M., Harmon J.W. A laboratory model for studying blast overpressure injury. The Journal of Trauma 1987, 27:349-356.
22. Jensen J.H., Bonding P. Experimental pressure induced rupture of the tympanic membrane in man. Acta Otolaryngo. 1993, 113:62-67.
23. Kopke R., Bielefeld E., Liu J., Zheng J., Jackson R., Henderson D., Coleman J.K.M. Prevention of impulse noise-induced hearing loss with antioxidants. Acta Oto-Laryngologica 2005, 125:235-243.
24. Kopke R.D., Jackson R.L., Coleman J.K.L., Liu J., Bielefeld E.C., Balugh B.J. NAC for noise: from bench top to the clinic. Hear Res. 2007, 226:114-125.
25. Kujawa S.G., Lieberman M.C. Adding insult to injury: cochlear nerve degeneration after " temporary" noise-induced hearing loss. J. Neurosci. 2009, 11:14077-14085.
26. Long J.B., Bently T.L., Wassner K.A., Cerone C., Sweeney S., Bauman R.A. Blast overpressure in rats: recreating a battlefield injury in the laboratory. J. Neurotrauma 2008, 26:827-840.
27. Lyden P.D., Shuaib A., Lees K.R., Davalos A., Davis S.M., Diener H.-C., Grotta J.C., Ashwood T.J., Hardemark H.G., Svensson H.H., Rodichok L., Wasiewski W.W., åhlberg G. Safety and tolerability of NXY-059 for acute intracerebral hemorrhage: the CHANT Trial. Stroke 2007, 38:2262-2269.
28. Maj R.H., Chait M.C. Blast injury of the ear: historical perspective. Ann. Otol. Rhinol. Laryngol. 1989, 98:9-12.
29. Nageris B.I., Attias J., Shemesh R. Otologic and audiologic lesions due to blast injury. J. Basic Clin. Physiol. Pharmacol. 2008, 19:185-191.
30. Nilsson D., Wemer J., Cheng Y.-F., Reinholdsson I., Englund G., Egberg N., Schulman S. Placebo-controlled, 3-period crossover phase I study NXY-059 does not affect bleeding time in healthy volunteers: a randomized, double-blind, placebo-controlled, 3-period crossover phase I study. J. Clin. Pharmacol. 2007, 47:264-272.
31. Ohlemiller K.K., Wright J.S., Dugan L.L. Early elevation of cochlear reactive oxygen species following noise exposure. Audiol. Neurootol. 1999, 4:229-236.
32. Patterson J.H., Hamernik R.P. Blast overpressure induced structural and functional changes in the auditory system. Toxicology 1997, 121:29-49.
33. Price G.R., Kim H., Lim D.J., Dunn D. Hazard from weapons impulses: historical and electrophysiological evidence. J. Acoust. Soc. Am. 1989, 85:1245-1254.
34. Richmond D.R., Fletcher E.R., Yelverton J.T., Phillips Y.Y. Physical correlates of eardrum rupture. Ann. Otol. Rhinol. Laryngol. 1989, 98:35-41.
35. Roberto M., Hamernik R.P., Turentine G.A. Damage of the auditory system associated with acute blast trauma. Ann. Otol. Rhinol. Laryngol. 1989, 98:23-34.
36. Svetlov S.I., Prima V., Kirk D.R., Gutierrrez H., Curley K.C., Hayes R.L., Wang K.W. Morphologic and biochemical characterization of brain injury in a model of controlled blast overpessure exposure. Trauma 2010, 69:795-804.
37. Wu A., Ying Z., Gomez-Pinilla F. Dietary curcumin counteracts the outcome of traumatic brain injury on oxidative stress, synaptic plasticity, and cognition. Exp. Neurol. 2006, 197:309-317.
38. Xiong Y., Peterson P.L., Lee C.P. Effect of N-acetylcysteine on mitochondrial function following traumatic brain injury in rats. J. Neurotrauma 1999, 16:1067-1082.
39. Xydakis M.S., Berbarta V.S., Harrison C.D., Conner J.C., Grant G.A. Tympanic membrane perforation as a marker of concussive brain injury in Iraq. N. Engl. J. Med. 2007, 357:830-831.
40. Ylikosi J. Impulse noise induced damage in the vestibular end organs of the guinea pig. Acta Otolaryngol. 1987, 103:415-421.