Utilization of a deuterated derivatization agent to synthesize internal standards for gas chromatography-tandem mass spectrometry quantification of silylated metabolites

Journal of Chromatography A

Volumn 1247, Issue , 2012, Pages 118-124

  Lien, Stina K ^a   Kvitvang, Hans Fredrik Nyvold ^a   Bruheim, Per ^a  

^a NORWEGIAN UNIVERSITY OF SCIENCE AND TECHNOLOGY   (Norway)

Author keywords

Data normalization; GC MS MS; Isotopically labelled derivatization agent; Metabolomics; Quantitative metabolic profiling; Silylation

Indexed keywords

DATA NORMALIZATION; DERIVATIZATIONS; GC-MS/MS; METABOLIC PROFILING; METABOLOMICS; SILYLATIONS;

AMINO ACIDS; BIOMOLECULES; BODY FLUIDS; DEUTERIUM; GAS CHROMATOGRAPHY; MASS SPECTROMETRY; STANDARDS; SUGARS;

METABOLITES;

2 OXOGLUTARIC ACID; ALANINE; CITRIC ACID; CYSTEINE; GLUCOSE; GLUTAMIC ACID; LYSINE; MANNITOL; N METHYL N TRIMETHYLSILYLTRIFLUOROACETAMIDE; PYRUVIC ACID; SUCCINIC ACID; TREHALOSE; TRIMETHYLSILYL DERIVATIVE; TYROSINE; UNCLASSIFIED DRUG; VALINE; XYLOSE;

ARTICLE; CONCENTRATION (PARAMETERS); CONTROLLED STUDY; DERIVATIZATION; FRAGMENTATION REACTION; IONIZATION; MASS FRAGMENTOGRAPHY; METABOLITE; METABOLOMICS; PRIORITY JOURNAL; PROCESS OPTIMIZATION; QUANTITATIVE ANALYSIS; REACTION OPTIMIZATION; SIGNAL NOISE RATIO; SILYLATION; STANDARD; STORAGE TEMPERATURE; TANDEM MASS SPECTROMETRY; TEMPERATURE SENSITIVITY;

ACETAMIDES; AMINO ACIDS; CARBOHYDRATES; CARBOXYLIC ACIDS; DEUTERIUM; FLUOROACETATES; GAS CHROMATOGRAPHY-MASS SPECTROMETRY; METABOLOMICS; REFERENCE STANDARDS; TANDEM MASS SPECTROMETRY; TRIFLUOROACETIC ACID; TRIMETHYLSILYL COMPOUNDS;

EID: 84862775514     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.05.053     Document Type: Article

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