Periurethral injection of autologous adipose-derived regenerative cells for the treatment of male stress urinary incontinence: Report of three initial cases

International Journal of Urology

Volumn 19, Issue 7, 2012, Pages 652-659

  Yamamoto, Tokunori ^a   Gotoh, Momokazu ^a   Kato, Masashi ^a   Majima, Tsuyoshi ^a   Toriyama, Kazuhiro ^a   Kamei, Yuzuru ^a   Iwaguro, Hideki ^b   Matsukawa, Yoshihisa ^a   Funahashi, Yasuhito ^a  

^a NAGOYA UNIVERSITY GRADUATE SCHOOL OF MEDICINE   (Japan)

^b Cytori Therapeutics Inc   (United States)

Author keywords

Adipose derived regenerative cells; Adipose derived stem cells; Injection; Prostatectomy; Stress urinary incontinence

Indexed keywords

ADIPOSE TISSUE CELL; AGED; ARTICLE; AUTOLOGOUS STEM CELL TRANSPLANTATION; BLADDER SPHINCTER; BLOOD FLOW; CASE REPORT; CELL THERAPY; FOLLOW UP; HEALTH SURVEY; HOLMIUM LASER; HUMAN; HUMAN CELL; LIPOSUCTION; MALE; NUCLEAR MAGNETIC RESONANCE IMAGING; PERIOPERATIVE PERIOD; POSTOPERATIVE PERIOD; PRIORITY JOURNAL; PROSTATECTOMY; QUALITY OF LIFE; STRESS INCONTINENCE; TRANSRECTAL ULTRASONOGRAPHY; TREATMENT OUTCOME; URETHRA DISEASE; URETHRA PRESSURE; URINE INCONTINENCE;

ADIPOSE TISSUE; AGED; HUMANS; INJECTIONS; MAGNETIC RESONANCE IMAGING; MALE; MULTIPOTENT STEM CELLS; QUALITY OF LIFE; TREATMENT OUTCOME; URETHRA; URINARY INCONTINENCE, STRESS; URODYNAMICS;

EID: 84862774775     PISSN: 09198172     EISSN: 14422042     Source Type: Journal    
DOI: 10.1111/j.1442-2042.2012.02999.x     Document Type: Article

References (30)

1. Carlson KV, Nitti VW. Prevention and management of incontinence following radical prostatectomy. Urol. Clin. North Am. 2001; 28: 595-612.
2. Arai Y, Kaiho Y, Takei M etal. Burden of male stress urinary incontinence: a survey among urologists in Japan. Int. J. Urol. 2009; 16: 915-17.
3. Okamura K, Nojiri Y, Seki N etal. Perioperative management of transurethral surgery for benign prostatic hyperplasia: a nationwide survey in Japan. Int. J. Urol. 2011; 18: 304-11.
4. Crivellaro S, Singla A, Aggarwal N, Frea B, Kocjancic E. Adjustable continence therapy (ProACT) and bone anchored male sling: complication of two new treatments of post prostatectomy incontinence. Int. J. Urol. 2008; 15: 910-14.
5. Fraser JK, Wulur I, Alfonso Z, Hedrick MH. Fat tissue. An underappreciated source of stem cells for biotechnology. Trends Biotechnol. 2006; 24: 150-4.
6. Jiang Y, Jahagirdar BN, Reinhardt RL etal. Pluripotency of mesenchymal stem cells derived from adult marrow. Nature 2002; 418: 41-9.
7. Nagaya N, Kanagawa K, Itoh T etal. Transplantation of mesenchymal stem cells improves cardiac function in a rat model of dilated cardiomyopathy. Circulation 2005; 112: 1128-35.
8. Safford KM, Hicok KC, Safford SD etal. Neurogenic differentiation of murine and human adipose-derived stromal cells. Biochem. Biophys. Res. Commun. 2002; 294: 371-9.
9. Gluckman E, Horowitz MM, Champlin RE etal. Bone marrow transplantation for severe aplastic anemia: influence of conditioning and graft-versus-host disease prophylaxis regimens on outcome. Blood 1992; 79: 269-75.
10. Banfi A, Bianchi G, Galotto M, Cancedda R, Quarto R. Bone marrow stromal damage after chemo/radiotherapy: occurrence, consequences and possibilities of treatment. Leuk. Lymphoma 2001; 42: 863-70.
11. Banfi A, Podesta M, Fazzuoli L etal. High-dose chemotherapy shows a dose-dependent toxicity to bone marrow osteoprogenitors: a mechanism for post-bone marrow transplantation osteopenia. Cancer 2001; 92: 2419-28.
12. Zuk PA, Zhu M, Ashjian P etal. Human adipose tissue is a source of multipotent stem cells. Mol. Biol. Cell 2002; 13: 4279-95.
13. Zuk PA, Zhu M, Mizuno H etal. Multilineage cells from human adipose tissue: implications for cell-based therapies. Tissue Eng. 2001; 7: 211-28.
14. Halvorsen YD, Franklin D, Bond AL etal. Extracellular matrix mineralization and osteoblast gene expression by human adipose tissue-derived stromal cells. Tissue Eng. 2001; 7: 729-41.
15. Rangappa S, Fen C, Lee EH, Bongso A, Sim EK. Transformation of adult mesenchymal stem cells isolated from the fatty tissue into cardiomyocytes. Ann. Thorac. Surg. 2003; 75: 775-9.
16. Rehman J, Traktuev D, Li J etal. Secretion of angiogenic and antiapoptotic factors by human adipose stromal cells. Circulation 2004; 109: 1292-8.
17. Lin K, Matsubara Y, Masuda Y etal. Charactrization of adipose tissue-derived cells isolated with the Celution TM system. Cytotherapy 2008; 10: 417-26.
18. Avery K, Avery K, Donovan J etal. The ICIQ, a brief and robust measure for evaluating the symptoms and impact of urinary incontinence. Neurourol. Urodyn. 2004; 23: 322-30.
19. Gotoh M, Homma Y, Funahashi Y, Matsukawa Y, Kato M. Psychometric validation of the Japanese version of the International Consultation on Incontinence Questionnaire-Short Form (ICIQ-SF). Int. J. Urol. 2009; 16: 303-6.
20. Hagen EK, Magnusson A, Aksnes AK, Norberg M. Enhanced visualization of the normal prostate blood flow in young healthy volunteers using a new ultrasound contrast agent. Acta Radiol. 2001; 42: 225-9.
21. Garcia-Olmo D, Garcia-Arranz M, Herreros D, Pascual I, Peiro C, Rodriguez-Montes JA. Phase I clinical trial of the treatment of Crohn's fistula by adipose mesenchymal stem cell transplantation. Dis. Colon Rectum 2005; 48: 1416-23.
22. Horwitz EM, Gordon PL, Koo WK etal. Isolated allogenetic bone marrow-derived mesenchymal cells engraft and stimulate growth in children with osteogenesis imperfect: implications for cell therapy of bone. Proc. Natl. Acad. Sci. U.S.A. 2002; 99: 8932-7.
23. Yoshimura K, Matsumoto D, Gonda K. A clinical trial of soft-tissue augmentation by lipoinjection with adipose-derived stromal cells (ASC). International Fat Applied Technology Society (IFATS);Third Annual Meeting 2005; 9-10.
24. Watanabe T, Maruyama S, Yamamoto T etal. Increased urethral resistance by periuretahral injection of low serum cultured adipose-derived mesenchymal stromal cells in rats. Int. J. Urol. 2011; 18: 659-66.
25. Dave DS, Gunther-Lopez V, Zhang R etal. Periurethral injection of autologous adipose-derived stem cells with hepatocyte growth factor-impregnated PLGA microsheres for treatment of stress incontinence in an animal model. J. Urol. 2008; 179 (Suppl): 568 (abstract).
26. Wu G, Song Y, Zheng X, Jiang Z. Adipose-derived stromal cell transplantation for treatment of stress urinary incontinence. Tissue Cell 2011; 43: 246-53.
27. Roche R, Festy F, Fritel X. Stem cells for stress urinary incontinence: the adipose promise. J. Cell. Mol. Med. 2010; 14: 135-42.
28. Carr LK, Steele D, Chancellor MB etal. 1-year follow-up of autologous muscle-derived stem cell injection pilot study to treat stress urinary incontinence. Int. Urogynecol. J. 2008; 19: 881-3.
29. Lee PE, Kung RC, Drutz HP. Periurethral autologous fat injection as treatment for female stress urinary incontinence: a randomized double-blind controlled trial. J. Urol. 2001; 165: 153-8.
30. Jack GS, Almeida FG, Zhang R, Alfonso ZC, Zuk PA, Rodriguez LV. Processed lipoaspirate cells for tissue engineering of the lower urinary tract: implications for the treatment of stress urinary incontinence and bladder reconstruction. J. Urol. 2005; 174: 2041-5.