Nesfatin-1 influences the excitability of glucosensing neurons in the hypothalamic nuclei and inhibits the food intake

Regulatory Peptides

Volumn 177, Issue 1-3, 2012, Pages 21-26

  Chen, Xi ^a   Dong, Jing ^a   Jiang, Zheng Yao ^a  

^a QINGDAO UNIVERSITY   (China)

Author keywords

Food intake; Glucosensing neurons; Lateral hypothalamus; Nesfatin 1; Paraventricular nucleus; Ventromedial nucleus

Indexed keywords

GLUCOSE; NESFATIN 1; NEUROPEPTIDE; UNCLASSIFIED DRUG;

ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; BRAIN NERVE CELL; CONTROLLED STUDY; FEEDING BEHAVIOR; FOOD INTAKE; GLUCOSE BLOOD LEVEL; GLUCOSE HOMEOSTASIS; GLUCOSENSING NEURON; HYPOTHALAMIC PARAVENTRICULAR NUCLEUS; HYPOTHALAMUS NUCLEUS; HYPOTHALAMUS VENTROMEDIAL NUCLEUS; LATERAL HYPOTHALAMUS; MALE; NERVE CELL EXCITABILITY; NONHUMAN; PRIORITY JOURNAL; PROTEIN FUNCTION; RAT; SATIETY;

ANIMALS; APPETITE DEPRESSANTS; APPETITE REGULATION; CALCIUM-BINDING PROTEINS; DNA-BINDING PROTEINS; EATING; GLUCOSE; HYPOTHALAMIC AREA, LATERAL; MALE; MEMBRANE POTENTIALS; MICROINJECTIONS; NERVE TISSUE PROTEINS; NEURAL PATHWAYS; NEURONS; PARAVENTRICULAR HYPOTHALAMIC NUCLEUS; RATS; RATS, WISTAR; TIME FACTORS; VENTROMEDIAL HYPOTHALAMIC NUCLEUS;

RATTUS;

EID: 84862774708     PISSN: 01670115     EISSN: 18731686     Source Type: Journal    
DOI: 10.1016/j.regpep.2012.04.003     Document Type: Article

References (16)

1. Oh-I S., Shimizu H., Satoh T., Okada S., Adachi S., Inoue K., Eguchi H., Yamamoto M., Imaki T., Hashimoto K., Tsuchiya T., Monden T., Horiguchi K., Yamada M., Mori M. Identification of nesfatin-1 as a satiety molecule in the hypothalamus. Nature 2006, 443:709-712.
2. Foo K., Brismar H., Broberger C. Distribution and neuropeptide coexistence of nucleobindin-2 mRNA/nesfatin-like immunoreactivity in the rat CNS. Neuroscience 2008, 156:563-579.
3. Fort P., Salvert D., Hanriot L., Jego S., Shimizu H., Hashimoto K., Mori M., Luppi P.H. The satiety molecule nesfatin-1 is co-expressed with melanin concentrating hormone in tuberal hypothalamic neurons of the rat. Neuroscience 2008, 155:174-181.
4. Kohno D., Nakata M., Maejima Y., Shimizu H., Sedbazar U., Yoshida N., Dezaki K., Onaka T., Mori M., Yada T. Nesfatin-1 neurons in paraventricular and supraoptic nuclei of the rat hypothalamus coexpress oxytocin and vasopressin and are activated by refeeding. Endocrinology 2008, 149:1295-1301.
5. Stengel A., Goebel M., Wang L., Rivier J., Kobelt P., Mönnikes H., Lambrecht N.W., Taché Y. Central nesfatin-1 reduces dark-phase food intake and gastric emptying in rats: differential role of corticotropin-releasing factor2 receptor. Endocrinology 2009, 150:4911-4919.
6. Yosten G.L., Samson W.K. Nesfatin-1 exerts cardiovascular actions in brain: possible interaction with the central melanocortin system. Am J Physiol Regul Integr Comp Physiol 2009, 297:R330-R336.
7. Maejima Y., Sedbazar U., Suyama S., Kohno D., Onaka T., Takano E., Yoshida N., Koike M., Uchiyama Y., Fujiwara K., Yashiro T., Horvath T.L., Dietrich M.O., Tanaka S., Dezaki K., Oh I.S., Hashimoto K., Shimizu H., Nakata M., Mori M., et al. Nesfatin-1 regulated oxytocinergic signaling in the paraventricular nucleus causes anorexia through a leptin-independent melanocortin pathway. Cell Metab 2009, 10:355-365.
8. Watts A.G., Donovan C.M. Sweet talk in the brain: glucosensing, neural networks, and hypoglycemic counterregulation. Front Neuroendocrinol 2010, 31:32-43.
9. Price C.J., Hoyda T.D., Samson W.K., Ferguson A.V. Nesfatin-1 influences the excitability of paraventricular nucleus neurones. J Neuroendocrinol 2008, 20:245-250.
10. Routh V.H. Glucose-sensing neurons: are they physiologically relevant?. Physiol Behav 2002, 76:403-413.
11. Burdakov D., Luckman S.M., Verkhratsky A. Glucose-sensing neurons of the hypothalamus. Philos Trans R Soc Lond B Biol Sci 2005, 360:2227-2235.
12. Paxinos G., Watson C. The rat brain in stereotaxic coordinates 1998, Academic Press, San Diego, California, USA. 4th edition.
13. Chen X., Ge Y.L., Jiang Z.Y., Liu C.Q., Depoortere I., Peeters T.L. Effects of ghrelin on hypothalamic glucose responding neurons in rats. Brain Res 2005, 1055:131-136.
14. Burdakov D., Gerasimenko O., Verkhratsky A. Physiological changes in glucose differentially modulate the excitability of hypothalamic melanin-concentrating hormone and orexin neurons in situ. J Neurosci 2005, 25:2429-2433.
15. Price C.J., Samson W.K., Ferguson A.V. Nesfatin-1 inhibits NPY neurons in the arcuate nucleus. Brain Res 2008, 1230:99-106.
16. Yamanaka A., Beuckmann C.T., Willie J.T., Hara J., Tsujino N., Mieda M., Tominaga M., Yagami K., Sugiyama F., Goto K., Yanagisawa M., Sakurai T. Hypothalamic orexin neurons regulate arousal according to energy balance in mice. Neuron 2003, 38:701-713.