Association of PDE4B polymorphisms and schizophrenia in Northwestern Han Chinese

Human Genetics

Volumn 131, Issue 7, 2012, Pages 1047-1056

  Guan, Fanglin ^a   Zhang, Chen ^b   Wei, Shuguang ^b   Zhang, Hongbo ^a   Gong, Xiaomin ^b   Feng, Jiali ^a   Gao, Chengge ^b   Su, Rong ^b   Yang, Huanming ^c   Li, Shengbin ^d  

^a BEIJING UNIVERSITY OF POSTS AND TELECOMMUNICATIONS   (China)

^b XI'AN JIAOTONG UNIVERSITY   (China)

^c BGI SHENZHEN   (China)

^d Institute of Human Genomics and Forensic Sciences   (China)

Author keywords

[No Author keywords available]

Indexed keywords

PHOSPHODIESTERASE IV; PHOSPHODIESTERASE IVB; UNCLASSIFIED DRUG;

ADULT; ARTICLE; CHINESE; CONTROLLED STUDY; DIAGNOSTIC TEST ACCURACY STUDY; FEMALE; GENE EXPRESSION; GENE FREQUENCY; GENE LOCUS; GENE MAPPING; GENETIC ANALYSIS; GENETIC ASSOCIATION; GENETIC SUSCEPTIBILITY; GENETIC VARIABILITY; HAPLOTYPE; HUMAN; INTRON; MAJOR CLINICAL STUDY; MALE; MINOR ALLELE FREQUENCY; PREVALENCE; PRIORITY JOURNAL; PROTEIN PROCESSING; RISK FACTOR; SCHIZOPHRENIA; SENSITIVITY AND SPECIFICITY; SEX DIFFERENCE; SINGLE NUCLEOTIDE POLYMORPHISM;

ADULT; ASIAN CONTINENTAL ANCESTRY GROUP; CASE-CONTROL STUDIES; CHINA; CYCLIC NUCLEOTIDE PHOSPHODIESTERASES, TYPE 4; FEMALE; GENE FREQUENCY; GENETIC PREDISPOSITION TO DISEASE; GENOTYPE; HAPLOTYPES; HUMANS; MALE; NERVE TISSUE PROTEINS; POLYMORPHISM, SINGLE NUCLEOTIDE; SCHIZOPHRENIA;

EID: 84862769717     PISSN: 03406717     EISSN: 14321203     Source Type: Journal    
DOI: 10.1007/s00439-011-1120-8     Document Type: Article

References (52)

1. IM Abraham AE Herbison 2005 Major sex differences in non-genomic estrogen actions on intracellular signaling in mouse brain in vivo Neuroscience 131 4 945 951 10.1016/j.neuroscience.2004.10.046 15749347 10.1016/j.neuroscience.2004. 10.046 1:CAS:528:DC%2BD2MXhvF2ntrY%3D
2. NC Andreasen 1995 Symptoms, signs, and diagnosis of schizophrenia Lancet 346 8973 477 481 7637483 10.1016/S0140-6736(95)91325-4 1:STN:280: DyaK2MzmsVGjuw%3D%3D
3. AP Auger 2003 Sex differences in the developing brain: crossroads in the phosphorylation of cAMP response element binding protein J Neuroendocrinol 15 6 622 627 12716414 10.1046/j.1365-2826.2003.01041.x 1:CAS:528:DC%2BD3sXktlylurk%3D
4. JC Barrett B Fry J Maller MJ Daly 2005 Haploview: analysis and visualization of LD and haplotype maps Bioinformatics 21 2 263 265 10.1093/bioinformatics/bth457 15297300 10.1093/bioinformatics/bth457 1:CAS:528:DC%2BD2MXkt1WitQ%3D%3D
5. Bradshaw NJ, Porteous DJ (2010) DISC1-binding proteins in neural development, signalling and schizophrenia. Neuropharmacology. doi: 10.1016/j.neuropharm.2010.12.027
6. Chen J, Zheng H, Bei JX, Sun L, Jia WH, Li T, Zhang F, Seielstad M, Zeng YX, Zhang X, Liu J (2009) Genetic structure of the Han Chinese population revealed by genome-wide SNP variation. Am J Hum Genet 85(6):775-785. doi: 10.1016/j.ajhg.2009.10.016
7. Chen P, Chen J, Huang K, Ji W, Wang T, Li T, Wang Y, Wang H, Feng G, He L, Shi Y (2011) Analysis of association between common SNPs in ErbB4 and bipolar affective disorder, major depressive disorder and schizophrenia in the Han Chinese population. Prog Neuropsychopharmacol Biol Psychiatry. doi: 10.1016/j.pnpbp.2011.09.011
8. YF Cheung Z Kan P Garrett-Engele I Gall H Murdoch GS Baillie LM Camargo JM Johnson MD Houslay JC Castle 2007 PDE4B5, a novel, super-short, brain-specific cAMP phosphodiesterase-4 variant whose isoform-specifying N-terminal region is identical to that of cAMP phosphodiesterase-4D6 (PDE4D6) J Pharmacol Exp Ther 322 2 600 609 10.1124/jpet.107.122218 17519386 10.1124/jpet.107.122218 1:CAS:528:DC%2BD2sXoslSjtLY%3D
9. JE Chubb NJ Bradshaw DC Soares DJ Porteous JK Millar 2008 The DISC locus in psychiatric illness Mol Psychiatr 13 1 36 64 10.1038/sj.mp.4002106 10.1038/sj.mp.4002106 1:CAS:528:DC%2BD2sXhsVegtLrO
10. N Craddock MC O'Donovan MJ Owen 2005 The genetics of schizophrenia and bipolar disorder: dissecting psychosis J Med Genet 42 3 193 204 10.1136/jmg.2005.030718 15744031 10.1136/jmg.2005.030718 1:CAS:528: DC%2BD2MXjtVersb0%3D
11. Curtis D, Xu K (2007) Minor differences in haplotype frequency estimates can produce very large differences in heterogeneity test statistics. BMC Genet 8:38. doi: 10.1186/1471-2156-8-38
12. D Curtis J Knight PC Sham 2006 Program report: GENECOUNTING support programs Ann Hum Genet 70 277 279 10.1111/j.1469-1809.2005.00225.x 16626337 10.1111/j.1529-8817.2005.00225.x 1:CAS:528:DC%2BD28Xkslams7s%3D
13. RL Davis J Cherry B Dauwalder PL Han E Skoulakis 1995 The cyclic AMP system and Drosophila learning Mol Cell Biochem 149-150 271 278 8569740 10.1007/BF01076588
14. PI De Bakker R Yelensky I Pe'er SB Gabriel MJ Daly D Altshuler 2005 Efficiency and power in genetic association studies Nat Genet 37 11 1217 1223 10.1038/ng1669 16244653 10.1038/ng1669
15. SH Fatemi DP King TJ Reutiman TD Folsom JA Laurence S Lee YT Fan SA Paciga M Conti FS Menniti 2008 PDE4B polymorphisms and decreased PDE4B expression are associated with schizophrenia Schizophr Res 101 1-3 36 49 10.1016/j.schres.2008.01.029 18394866 10.1016/j.schres.2008.01.029
16. SB Gabriel SF Schaffner H Nguyen JM Moore J Roy B Blumenstiel J Higgins M DeFelice A Lochner M Faggart SN Liu-Cordero C Rotimi A Adeyemo R Cooper R Ward ES Lander MJ Daly D Altshuler 2002 The structure of haplotype blocks in the human genome Science 296 5576 2225 2229 10.1126/science.1069424 12029063 10.1126/science.1069424 1:CAS:528:DC%2BD38XkvFGhtrc%3D
17. Harrison PJ, Weinberger DR (2005) Schizophrenia genes, gene expression, and neuropathology: on the matter of their convergence. Mol Psychiatry 10(1):40-68; image 45. doi: 10.1038/sj.mp.4001558
18. W Hennah P Thomson L Peltonen D Porteous 2006 Genes and schizophrenia: beyond schizophrenia: the role of DISC1 in major mental illness Schizophr Bull 32 3 409 416 10.1093/schbul/sbj079 16699061 10.1093/schbul/sbj079
19. EG Holliday DR Nyholt S Tirupati S John P Ramachandran M Ramamurti AJ Ramadoss A Jeyagurunathan S Kottiswaran HJ Smith C Filippich DA Nertney DJ Nancarrow NK Hayward WS Watkins LB Jorde R Thara BJ Mowry 2009 Strong Evidence for a Novel Schizophrenia Risk Locus on Chromosome 1p31.1 in Homogeneous Pedigrees From Tamil Nadu, India Am J Psychiat 166 2 206 215 10.1176/appi.ajp.2008.08030442 18829870 10.1176/appi.ajp.2008.08030442
20. MD Houslay DR Adams 2003 PDE4 cAMP phosphodiesterases: modular enzymes that orchestrate signalling cross-talk, desensitization and compartmentalization Biochem J 370 1 18 12444918 10.1042/BJ20021698 1:CAS:528:DC%2BD3sXhtVKktbc%3D
21. MD Houslay P Schafer KY Zhang 2005 Keynote review: phosphodiesterase-4 as a therapeutic target Drug Discov Today 10 22 1503 1519 10.1016/S1359-6446(05) 03622-6 16257373 10.1016/S1359-6446(05)03622-6 1:CAS:528:DC%2BD2MXhtFKmsrzL
22. K Ishizuka M Paek A Kamiya A Sawa 2006 A review of Disrupted-In- Schizophrenia-1 (DISC1): neurodevelopment, cognition, and mental conditions Biol Psychiatry 59 12 1189 1197 10.1016/j.biopsych.2006.03.065 16797264 10.1016/j.biopsych.2006.03.065 1:CAS:528:DC%2BD28XmtVOit7g%3D
23. AK Kahler MK Otnaess KV Wirgenes T Hansen EG Jonsson I Agartz H Hall T Werge G Morken O Mors E Mellerup H Dam P Koefod I Melle VM Steen OA Andreassen S Djurovic 2009 Association study of PDE4B gene variants in Scandinavian schizophrenia and bipolar disorder multicenter case-control samples Am J Med Genet B Neuropsychiatr Genet 153B 1 86 96 10.1002/ajmg.b.30958
24. XY Ke LR Cardon 2003 Efficient selective screening of haplotype tag SNPs Bioinformatics 19 2 287 288 12538253 10.1093/bioinformatics/19.2.287 1:CAS:528:DC%2BD3sXitlCnsbs%3D
25. MP Kelly C Isiegas YF Cheung J Tokarczyk X Yang MF Esposito DA Rapoport SA Fabian SJ Siegel G Wand MD Houslay SJ Kanes T Abel 2007 Constitutive activation of Galphas within forebrain neurons causes deficits in sensorimotor gating because of PKA-dependent decreases in cAMP Neuropsychopharmacol 32 3 577 588 10.1038/sj.npp.1301099 10.1038/sj.npp.1301099 1:CAS:528:DC%2BD2sXhslWhurs%3D
26. King DP, Paciga SA, Fan Y, Menniti FS (2006) Positive genetic association of phosphodiesterase 4B (PDE4B) with schizophrenia: analysis in two case-control populations. neuroscience meeting planner, vol Program no. 94.20. Society for Neuroscience, Atlanta
27. J Lai Y Zhu Z Huo R Sun B Yu Y Wang Z Chai S Li 2010 Association study of polymorphisms in the promoter region of DRD4 with schizophrenia, depression, and heroin addiction Brain Res 1359 227 232 20801104 10.1016/j.brainres.2010.08. 064 1:CAS:528:DC%2BC3cXhtlSgt73E
28. H Le Hir A Nott MJ Moore 2003 How introns influence and enhance eukaryotic gene expression Trends Biochem Sci 28 4 215 220 10.1016/S0968- 0004(03)00052-5 12713906 10.1016/S0968-0004(03)00052-5 1:CAS:528: DC%2BD3sXjtFeqtr0%3D
29. J Ma W Qin XY Wang TW Guo L Bian SW Duan XW Li FG Zou YR Fang JX Fang GY Feng NF Gu D St Clair L He 2006 Further evidence for the association between G72/G30 genes and schizophrenia in two ethnically distinct populations Mol Psychiatry 11 5 479 487 16402132 10.1038/sj.mp.4001788 1:CAS:528: DC%2BD28XjslKksr0%3D
30. Menashe I, Rosenberg PS, Chen BE (2008) PGA: power calculator for case-control genetic association analyses. BMC Genet 9:36. doi: 10.1186/1471-2156-9-36
31. JK Millar BS Pickard S Mackie R James S Christie SR Buchanan MP Malloy JE Chubb E Huston GS Baillie PA Thomson EV Hill NJ Brandon JC Rain LM Camargo PJ Whiting MD Houslay DHR Blackwood WJ Muir DJ Porteous 2005 DISC1 and PDE4B are interacting genetic factors in schizophrenia that regulate cAMP signaling Science 310 5751 1187 1191 10.1126/science.1112915 16293762 10.1126/science. 1112915 1:CAS:528:DC%2BD2MXht1WgtLbL
32. KT Mueser SR McGurk 2004 Schizophrenia Lancet 363 9426 2063 2072 15207959 10.1016/S0140-6736(04)16458-1
33. C Muly 2002 Signal transduction abnormalities in schizophrenia: the cAMP system Psychopharmacol Bull 36 4 92 105 12858148
34. H Murdoch S Mackie DM Collins EV Hill GB Bolger E Klussmann DJ Porteous JK Millar MD Houslay 2007 Isoform-selective susceptibility of DISC1/phosphodiesterase-4 complexes to dissociation by elevated intracellular cAMP levels J Neurosci 27 35 9513 9524 10.1523/JNEUROSCI.1493-07.2007 17728464 10.1523/JNEUROSCI.1493-07.2007 1:CAS:528:DC%2BD2sXhtVaksLzJ
35. DM Nielsen MG Ehm BS Weir 1998 Detecting marker-disease association by testing for Hardy-Weinberg disequilibrium at a marker locus Am J Hum Genet 63 5 1531 1540 9867708 10.1086/302114 1:STN:280:DyaK1M%2FotV2rsg%3D%3D
36. S Numata SI Ueno JI Iga S Hongwei M Nakataki S Tayoshi S Sumitani M Tomotake M Itakura A Sano T Ohmori 2008 Positive association of the PDE4B (phosphodiesterase 4B) gene with schizophrenia in the Japanese population J Psychiatr Res 43 1 7 12 10.1016/j.jpsychires.2008.01.013 18329668 10.1016/j.jpsychires.2008.01.013
37. NA Patsopoulos A Tatsioni JPA Ioannidis 2007 Claims of sex differences-an empirical assessment in genetic associations JAMA 298 8 880 893 17712072 10.1001/jama.298.8.880 1:CAS:528:DC%2BD2sXpsFCrsr0%3D
38. BS Pickard PA Thomson A Christoforou KL Evans SW Morris DJ Porteous DHR Blackwood WJ Muir 2007 The PDE4B gene confers sex-specific protection against schizophrenia Psychiatr Genet 17 3 129 133 17417055 10.1097/YPG.0b013e328014492b
39. A Rastogi C Zai O Likhodi JL Kennedy AH Wong 2009 Genetic association and post-mortem brain mRNA analysis of DISC1 and related genes in schizophrenia Schizophr Res 114 1-3 39 49 10.1016/j.schres.2009.06.019 19632097 10.1016/j.schres.2009.06.019
40. Ripke S, Sanders AR, Kendler KS, Levinson DF, Sklar P, Holmans PA, Lin DY, Duan J, Ophoff RA, Andreassen OA, Scolnick E, Cichon S, St. Clair D, Corvin A, Gurling H, Werge T, Rujescu D, Blackwood DH, Pato CN, Malhotra AK, Purcell S, Dudbridge F, Neale BM, Rossin L, Visscher PM, Posthuma D, Ruderfer DM, Fanous A, Stefansson H, Steinberg S, Mowry BJ, Golimbet V, De Hert M, Jönsson EG, Bitter I, Pietiläinen OP, Collier DA, Tosato S, Agartz I, Albus M, Alexander M, Amdur RL, Amin F, Bass N, Bergen SE, Black DW, Børglum AD, Brown MA, Bruggeman R, Buccola NG, Byerley WF, Cahn W, Cantor RM, Carr VJ, Catts SV, Choudhury K, Cloninger CR, Cormican P, Craddock N, Danoy PA, Datta S, de Haan L, Demontis D, Dikeos D, Djurovic S, Donnelly P, Donohoe G, Duong L, Dwyer S, Fink-Jensen A, Freedman R, Freimer NB, Friedl M, Georgieva L, Giegling I, Gill M, Glenthøj B, Godard S, Hamshere M, Hansen M, Hansen T, Hartmann AM, Henskens FA, Hougaard DM, Hultman CM, Ingason A, Jablensky AV, Jakobsen KD, Jay M, Jürgens G, Kahn RS, Keller MC, Kenis G, Kenny E, Kim Y, Kirov GK, Konnerth H, Konte B, Krabbendam L, Krasucki R, Lasseter VK, Laurent C, Lawrence J, Lencz T, Lerer FB, Liang KY, Lichtenstein P, Lieberman JA, Linszen DH, Lönnqvist J, Loughland CM, Maclean AW, Maher BS, Maier W, Mallet J, Malloy P, Mattheisen M, Mattingsdal M, McGhee KA, McGrath JJ, McIntosh A, McLean DE, McQuillin A, Melle I, Michie PT, Milanova V, Morris DW, Mors O, Mortensen PB, Moskvina V, Muglia P, Myin-Germeys I, Nertney DA, Nestadt G, Nielsen J, Nikolov I, Nordentoft M, Norton N, Nöthen MM, O'Dushlaine CT, Olincy A, Olsen L, O'Neill FA, Orntoft TF, Owen MJ, Pantelis C, Papadimitriou G, Pato MT, Peltonen L, Petursson H, Pickard B, Pimm J, Pulver AE, Puri V, Quested D, Quinn EM, Rasmussen HB, Réthelyi JM, Ribble R, Rietschel M, Riley BP, Ruggeri M, Schall U, Schulze TG, Schwab SG, Scott RJ, Shi J, Sigurdsson E, Silverman JM, Spencer CC, Stefansson K, Strange A, Strengman E, Stroup TS, Suvisaari J, Terenius L, Thirumalai S, Thygesen JH, Timm S, Toncheva D, van den Oord E, van Os J, van Winkel R, Veldink J, Walsh D, Wang AG, Wiersma D, Wildenauer DB, Williams HJ, Williams NM, Wormley B, Zammit S, Sullivan PF, O'Donovan MC, Daly MJ, Gejman PV; Schizophrenia Psychiatric Genome-Wide Association Study (GWAS) Consortium (2011) Genome-wide association study identifies five new schizophrenia loci. Nat Genet 43(10):969-976. doi: 10.1038/ng.940
41. CA Ross RL Margolis SA Reading M Pletnikov JT Coyle 2006 Neurobiology of schizophrenia Neuron 52 1 139 153 10.1016/j.neuron.2006.09.015 17015232 10.1016/j.neuron.2006.09.015 1:CAS:528:DC%2BD28XhtFentr7I
42. F Rousset M Raymond 1995 Testing heterozygote excess and deficiency Genetics 140 4 1413 1419 7498780 1:STN:280:DyaK287itVemtA%3D%3D
43. DJ Schaid CM Rowland DE Tines RM Jacobson GA Poland 2002 Score tests for association between traits and haplotypes when linkage phase is ambiguous Am J Hum Genet 70 2 425 434 11791212 10.1086/338688
44. PC Sham D Curtis 1995 Monte-Carlo tests for associations between disease and alleles at highly polymorphic loci Ann Hum Genet 59 97 105 7762987 10.1111/j.1469-1809.1995.tb01608.x 1:STN:280:DyaK2M3otlansg%3D%3D
45. S Shifman M Bronstein M Sternfeld A Pisante-Shalom E Lev-Lehman A Weizman I Reznik B Spivak N Grisaru L Karp R Schiffer M Kotler RD Strous M Swartz-Vanetik HY Knobler E Shinar JS Beckmann B Yakir N Risch NB Zak A Darvasi 2002 A highly significant association between a COMT haplotype and schizophrenia Am J Hum Genet 71 6 1296 1302 12402217 10.1086/344514 1:CAS:528:DC%2BD3sXjsV2m
46. L Tomppo W Hennah P Lahermo A Loukola A Tuulio-Henriksson J Suvisaari T Partonen J Ekelund J Lonnqvist L Peltonen 2009 Association between genes of Disrupted in Schizophrenia 1 (DISC1) interactors and schizophrenia supports the role of the DISC1 pathway in the etiology of major mental illnesses Biol Psychiat 65 12 1055 1062 10.1016/j.biopsych.2009.01.014 19251251 10.1016/j.biopsych.2009.01.014 1:CAS:528:DC%2BD1MXms1Oqtbo%3D
47. Y Wei C Li S Li Y Liu L Hu 2011 Association study of monoamine oxidase A/B genes and schizophrenia in Han Chinese Behav Brain Funct 7 42 10.1186/1744-9081-7-42 21978760 10.1186/1744-9081-7-42 1:CAS:528: DC%2BC3MXhsFGjs77K
48. Xu S, Yin X, Li S, Jin W, Lou H, Yang L, Gong X, Wang H, Shen Y, Pan X, He Y, Yang Y, Wang Y, Fu W, An Y, Wang J, Tan J, Qian J, Chen X, Zhang X, Sun Y, Zhang X, Wu B, Jin L (2009) Genomic dissection of population substructure of Han Chinese and its implication in association studies. Am J Hum Genet 85(6):762-774. doi: 10.1016/j.ajhg.2009.10.015
49. R Zhang SM Lu C Qiu XG Liu CG Gao TW Guo RK Valenzuela HW Deng J Ma 2011 Population-based and family-based association studies of ZNF804A locus and schizophrenia Mol Psychiatry 16 4 360 361 20458322 10.1038/mp.2010.55 1:CAS:528:DC%2BC3MXjslCmt7o%3D
50. JH Zhao PC Sham 2003 Generic number systems and haplotype analysis Comput Methods Prog Biomed 70 1 9 10.1016/S0169-2607(01)00193-6
51. JH Zhao D Curtis PC Sham 2000 Model-free analysis and permutation tests for allelic associations Hum Hered 50 2 133 139 10799972 10.1159/000022901 1:CAS:528:DC%2BD3cXhtVaiuw%3D%3D
52. JH Zhao S Lissarrague L Essioux PC Sham 2002 GENECOUNTING: haplotype analysis with missing genotypes Bioinformatics 18 12 1694 1695 12490459 10.1093/bioinformatics/18.12.1694 1:CAS:528:DC%2BD38XpslOhtbo%3D