Plasma levodopa peak delay and impaired gastric emptying in Parkinson's disease

Journal of the Neurological Sciences

Volumn 319, Issue 1-2, 2012, Pages 86-88

  Doi, Hirokazu ^a   Sakakibara, Ryuji ^a   Sato, Mitsutoshi ^a   Masaka, Tohru ^a   Kishi, Masahiko ^a   Tateno, Akihiko ^a   Tateno, Fuyuki ^a   Tsuyusaki, Yohei ^a   Takahashi, Osamu ^a  

^a TOHO UNIVERSITY   (Japan)

Author keywords

Constipation; Gastric emptying; Parkinson's disease; Plasma levodopa concentration

Indexed keywords

CARBIDOPA PLUS LEVODOPA; LEVODOPA; OCTANOIC ACID C 13;

AGED; ARTICLE; CLINICAL ARTICLE; CONSTIPATION; DISEASE DURATION; DRUG BLOOD LEVEL; EXPIRED AIR; FEMALE; HUMAN; MALE; PARKINSON DISEASE; PRIORITY JOURNAL; STOMACH EMPTYING; TIME TO MAXIMUM PLASMA CONCENTRATION; UNIFIED PARKINSON DISEASE RATING SCALE;

AGED; ANTIPARKINSON AGENTS; BREATH TESTS; FEMALE; GASTRIC EMPTYING; GASTROPARESIS; HUMANS; LEVODOPA; MALE; MIDDLE AGED; PARKINSON DISEASE;

EID: 84862764529     PISSN: 0022510X     EISSN: 18785883     Source Type: Journal    
DOI: 10.1016/j.jns.2012.05.010     Document Type: Article

References (12)

1. Melamed E, Ziv I, Djaldetti R. Management of motor complications in advanced Parkinson's disease. Mov Disord 2007;22(Suppl. 17):S379-84. (Pubitemid 350134192)
2. Evans MA, Broe GA, Triggs EJ, Cheung M, Creasey H, Paull PD. Gastric emptying rate and the systemic availability of levodopa in the elderly parkinsonian patient. Neurology 1981;31:1288-94. (Pubitemid 11026847)
3. Dizdar N, Granérus AK, Hannestad U, Kullman A, Ljungdahl A, Olsson JE, et al. L-dopa pharmacokinetics studied with microdialysis in patients with Parkinson's disease and a history of malignant melanoma. Acta Neurol Scand 1999;100:231-7. (Pubitemid 29428397)
4. Hughes AJ, Daniel SE, Kilford L, Lees AJ. Accuracy of clinical diagnosis of idiopathic Parkinson's disease: a clinicopathological study of 100 cases. J Neurol Neurosurg Psychiatry 1992;55:181-4.
5. Yeh KC, August TF, Bush DF, Lasseter KC, Musson DG, Schwartz S, et al. Pharmacokinetics and bioavailability of Sinemet CR: a summary of human studies. Neurology 1989;39(11 Suppl 2):25-38. (Pubitemid 20020578)
6. Ghoos YF, Maes BD, Geypens BJ, Mys G, Hiele MI, Rutgeerts PJ, et al. Measurement of gastric emptying rate of solids by means of a carbon-labeled octanoic acid breath test. Gastroenterology 1993;104:1640-7. (Pubitemid 23235453)
7. Horowitz M, Dent J, Fraser R, Sun W, Hebbard G. Role and integration of mechanisms controlling Gastric emptying. Dig Dis Sci 1994;39:S7-S13.
8. Lin HC, van Citters GW, Heimer F, Bonorris G. Slowing of gastrointestinal transit by oleic acid: a preliminary report of a novel, nutrient-based treatment in humans. Dig Dis Sci 2001;46:223-9. (Pubitemid 32243490)
9. Delgado-Aros S, Camilleri M, Cremonini F, Ferber I, Stephens D, Burton DD. Contributions of gastric volumes and gastric emptying to meal size and postmeal symptoms in functional dyspepsia. Gastroenterology 2004;127:1685-94. (Pubitemid 39575847)
10. Jain S. Multi-organ autonomic dysfunction in Parkinson disease. Parkinsonism Relat Disord 2011;17:77-83.
11. Sakakibara R, Kishi M, Ogawa E, Tateno F, Uchiyama T, Yamamoto T, et al. Bladder, bowel, and sexual dysfunction in Parkinson's disease. Parkinsons Dis 2011:924605 Epub 2011 Sep 12.
12. Tateno F, Sakakibara R, Yokoi Y, Kishi M, Ogawa E, Uchiyama T, et al. Levodopa ameliorated anorectal constipation in de novo Parkinson's disease: the QL-GAT study. Parkinsonism Relat Disord 2011;17:662-6.