Association of aureolic acid antibiotic, chromomycin A3 with Cu 2+ and its negative effect upon DNA binding property of the antibiotic

BioMetals

Volumn 25, Issue 2, 2012, Pages 435-450

  Lahiri, Shibojyoti ^a   Takao, Toshifumi ^b   Devi, Pukhrambam Grihanjali ^a,c   Ghosh, Saptaparni ^a   Ghosh, Ayanjeet ^a,d   Dasgupta, Amrita ^a,e   Dasgupta, Dipak ^a  

^a SAHA INSTITUTE OF NUCLEAR PHYSICS   (India)

^b OSAKA UNIVERSITY   (Japan)

^c Department of Chemistry   (India)

^d UNIVERSITY OF PENNSYLVANIA   (United States)

^e TATA INSTITUTE OF FUNDAMENTAL RESEARCH   (India)

Author keywords

Chromomycin; Copper ion; Distorted octahedral structure; DNA binding; Electrospray ionization mass spectrometry; Multiple equilibria

Indexed keywords

CHROMOMYCIN A3; COPPER COMPLEX; COPPER ION; DNA; MAGNESIUM DERIVATIVE; MAGNESIUM ION; MITHRAMYCIN; ZINC COMPLEX; ZINC ION;

ARTICLE; BINDING AFFINITY; CIRCULAR DICHROISM; COMPLEX FORMATION; CONTROLLED STUDY; DISSOCIATION CONSTANT; DNA DRUG COMPLEX; DNA HELIX; DRUG CONFORMATION; DRUG DNA BINDING; DRUG DNA INTERACTION; DRUG STRUCTURE; ENTHALPY; ENTROPY; ISOTHERMAL TITRATION CALORIMETRY; PH; PROTON NUCLEAR MAGNETIC RESONANCE; STOICHIOMETRY; STRUCTURE ANALYSIS; TEMPERATURE SENSITIVITY;

ANTIBIOTICS, ANTINEOPLASTIC; CHROMOMYCIN A3; COPPER; DNA; PLICAMYCIN; SPECTROMETRY, MASS, ELECTROSPRAY IONIZATION; THERMODYNAMICS; ZINC;

EID: 84862763959     PISSN: 09660844     EISSN: 15728773     Source Type: Journal    
DOI: 10.1007/s10534-011-9516-4     Document Type: Article

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