Fenoterol enantiomers do not possess beneficial therapeutic properties of their racemic mixture in the rat model of post myocardial infarction dilated cardiomyopathy

Cardiovascular Drugs and Therapy

Volumn 26, Issue 2, 2012, Pages 101-108

  Ahmet, Ismayil ^a   Turner, Tia ^a   Lakatta, Edward G ^a   Talan, Mark I ^a  

^a NATIONAL INSTITUTE ON AGING   (United States)

Author keywords

2 adrenergic receptor agonists; Cardiac remodeling; Chronic heart failure; Fenoterol; Stereoisomers of fenoterol

Indexed keywords

FENOTEROL; PLACEBO;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CARDIOVASCULAR FUNCTION; CONGESTIVE CARDIOMYOPATHY; CONTINUOUS INFUSION; CONTROLLED STUDY; DRUG EFFICACY; ECHOCARDIOGRAPHY; ENANTIOMER; FUNCTIONAL DISEASE; HEART INFARCTION; HEART INFARCTION SIZE; LEFT ANTERIOR DESCENDING CORONARY ARTERY; LEFT VENTRICULAR REMODELING; MALE; NONHUMAN; PRIORITY JOURNAL; RACEMIC MIXTURE; RAT; SYSTOLIC BLOOD PRESSURE;

ADRENERGIC BETA-2 RECEPTOR AGONISTS; ANIMALS; CARDIOMYOPATHY, DILATED; CORONARY VESSELS; ECHOCARDIOGRAPHY; FENOTEROL; HEART FAILURE; MALE; MYOCARDIAL INFARCTION; MYOCYTES, CARDIAC; RATS; RATS, WISTAR; STEREOISOMERISM; VENTRICULAR REMODELING;

EID: 84862763720     PISSN: 09203206     EISSN: 15737241     Source Type: Journal    
DOI: 10.1007/s10557-011-6366-9     Document Type: Article

References (17)

1. Xu J, Kochanek KD, Murphy SL, Tejada-Vera B. Deaths: final data for 2007. NVSR. 2010;58:1-135.
2. Ahmet I, Lakatta EG, Talan MI. Pharmacological stimulation of beta2-adrenergic receptors (beta2AR) enhances therapeutic effectiveness of beta1AR blockade in rodent dilated ischemic cardiomyopathy. Heart Fail Rev. 2005;10:289-96.
3. Ahmet I, Krawczyk M, Zhu W, Woo AY, Morrell C, Poosala S, et al. Cardioprotective and survival benefits of long-term combined therapy with beta2 adrenoreceptor (AR) agonist and beta1 AR blocker in dilated cardiomyopathy postmyocardial infarction. J Pharmacol Exp Ther. 2008;325:491-9. (Pubitemid 351574789)
4. Ahmet I, Morrell C, Lakatta EG, Talan MI. Therapeutic efficacy of a combination of a beta1-adrenoreceptor (AR) blocker and beta2-AR agonist in a rat model of postmyocardial infarction dilated heart failure exceeds that of a beta1-AR blocker plus angiotensin-converting enzyme inhibitor. J Pharmacol Exp Ther. 2009;331:178-85.
5. Talan MI, Ahmet I, Xiao RP, Lakatta EG. β(2) AR agonists in treatment of chronic heart failure: long path to translation. J Mol Cell Cardiol. 2011;51:529-31.
6. 2-adrenergic receptor delivers an anti-apoptotic signal to cardiac myocytes through Gi-dependent signaling pathways. Circ Res. 2000;87:1172-9.
7. 2- adrenergic signaling in adult mouse heart cells. Proc Natl Acad Sci USA. 2001;98:1607-12. (Pubitemid 32165546)
8. 2+/Calmodulin Kinase II. J Clin Invest. 2003;111:617-25. (Pubitemid 36278580)
9. Zheng M, Zhu W, Han Q, Xiao RP. Emerging concepts and therapeutic implications of β-adrenergic receptor subtype signaling. Pharmacol Ther. 2005;509:109-15.
10. Jozwiak K, Khalid C, Tanga MJ, Berzetei-Gurske I, Jimenez L, Kozocas JA, et al. Comparative molecular field analysis of the binding of the stereoisomers of fenoterol and fenoterol derivatives to the beta2 adrenergic receptor. J Med Chem. 2007;50:2903-15. (Pubitemid 46980861)
11. Beigi F, Bertucci C, Zhu W, Chakir K, Wainer IW, Xiao RP, et al. Enantioselective separation and online affinity chromatographic characterization of R, R- and S, S-fenoterol. Chirality. 2006;18:822-7. (Pubitemid 44619175)
12. Woo AY, Wang TB, Zeng X, ZhuW, Abernethy DR, Wainer IW, et al. Stereochemistry of an agonist determines coupling preference of beta2-adrenoceptor to different G proteins in cardiomyocytes. Mol Pharmacol. 2009;75:158-65.
13. Kim HS, Siluk D, Wainer IW. Quantitative determination of fenoterol and fenoterol derivatives in rat plasma using on-line immunoextraction and liquid chromotography/mass spectrometry. J Chromatogr A. 2009;1216:3526-32.
14. Ahmet I, Krawczyk M, Heller P, Moon C, Lakatta EG, Talan MI. Beneficial effects of chronic pharmacological manipulation of beta-adrenoreceptor subtype signaling in rodent dilated ischemic cardiomyopathy. Circulation. 2004;110:1083-90. (Pubitemid 39319006)
15. 2-adrenoceptor to a pertussis toxin-sensitive G protein in cardiac myocytes. Mol Pharmacol. 1995;47:322-9.
16. 2-adrenoceptor to Gi proteins and its physiological relevance in murine cardiac myocytes. Circ Res. 1999;84:43-52. (Pubitemid 29074879)
17. 2-adrenergic contractile response in failing spontaneous hypertensive rat heart. Circulation. 2003;108:1633-9.