A method for the generation of Pamys-based lipopeptide mimics via CuAAC click chemistry

Synlett

Volumn 23, Issue 11, 2012, Pages 1617-1620

  Yeung, Ho ^a   Lee, Dong Jun ^a   Williams, Geoffrey M ^a   Harris, Paul W R ^a   Dunbar, Rod P ^a   Brimble, Margaret A ^a  

^a UNIVERSITY OF AUCKLAND   (New Zealand)

Author keywords

click chemistry; CuAAC; lipopeptides; Pamys

Indexed keywords

4 AMINOPYRIDINE; [2,3 BIS(PALMITOYLOXY)PROPYL]CYSTEINE; AZIDE; IMMUNOLOGICAL ADJUVANT; LIPOPEPTIDE; PALMITIC ACID; PEPTIDOMIMETIC AGENT; SYNTHETIC PEPTIDE; UNCLASSIFIED DRUG;

AMINO TERMINAL SEQUENCE; ARTICLE; CLICK CHEMISTRY; DEPROTECTION REACTION; DRUG IDENTIFICATION; DRUG STRUCTURE; DRUG SYNTHESIS; ESTERIFICATION; IMMUNOSTIMULATION; MASS SPECTROMETRY; NUCLEAR MAGNETIC RESONANCE SPECTROSCOPY; PEPTIDE SYNTHESIS; REACTION ANALYSIS; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SOLID PHASE EXTRACTION; SOLID PHASE SYNTHESIS; TEMPERATURE SENSITIVITY;

EID: 84862757081     PISSN: 09365214     EISSN: 14372096     Source Type: Journal    
DOI: 10.1055/s-0031-1291148     Document Type: Article

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6. SPPS of the target peptide was undertaken using Fmoc-Lys(Boc)-WANG resin (0.142 g, 0.7 mmol/g loading, 0.1 mmol scale) using microwave-enhanced Fmoc-SPPS as described in: Harris P, Williams G, Shepherd P, Brimble M. Int. J. Pept. Res. Ther.: 2008; 14 387