Physicochemical characterization of complex drug substances: Evaluation of structural similarities and differences of protamine sulfate from various sources

AAPS Journal

Volumn 14, Issue 3, 2012, Pages 619-626

  Awotwe Otoo, David ^a   Agarabi, Cyrus ^a   Keire, David ^a   Lee, Sau ^a   Raw, Andre ^a   Yu, Lawrence ^a   Habib, Muhammad J ^b   Khan, Mansoor A ^a   Shah, Rakhi B ^a  

^a CENTER FOR DRUG EVALUATION AND RESEARCH   (United States)

^b HOWARD UNIVERSITY   (United States)

Author keywords

circular dichroism; differential scanning calorimetry; Fourier transform infrared spectroscopy; nuclear magnetic resonance; peptide; protamine sulfate; thermogravimetric analysis

Indexed keywords

AMIDE; PEPTIDE; PROTAMINE SULFATE; PROTEIN;

ANALYTIC METHOD; ARTICLE; BETA SHEET; CIRCULAR DICHROISM; CONTROLLED STUDY; DIFFERENTIAL SCANNING CALORIMETRY; DRUG CONFORMATION; DRUG STRUCTURE; GLASS TRANSITION TEMPERATURE; INFRARED SPECTROSCOPY; MELTING POINT; MOISTURE; PROTON NUCLEAR MAGNETIC RESONANCE; THERMAL ANALYSIS; THERMOGRAVIMETRY;

CALORIMETRY, DIFFERENTIAL SCANNING; CIRCULAR DICHROISM; MAGNETIC RESONANCE SPECTROSCOPY; PROTAMINES; SPECTROSCOPY, FOURIER TRANSFORM INFRARED; THERMOGRAVIMETRY;

EID: 84862756371     PISSN: 15507416     EISSN: None     Source Type: Journal    
DOI: 10.1208/s12248-012-9375-0     Document Type: Article

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