Bleeding-associated outcomes with preoperative clopidogrel use in on- and off-pump coronary artery bypass

Journal of Thrombosis and Thrombolysis

Volumn 34, Issue 1, 2012, Pages 56-64

  Berger, Jeffrey S ^a   Herout, Peter M ^b   Harshaw, Qing ^c   Steinhubl, Steven R ^d   Frye, Carla B ^c   Becker, Richard C ^e  

^a NEW YORK UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b Cardinal Health   (United States)

^c EPI Q Inc   (United States)

^d GEISINGER HEALTH SYSTEM   (United States)

^e DUKE UNIVERSITY MEDICAL CENTER   (United States)

Author keywords

Bleeding; CABG: Clopidogrel; Off pump; Reoperation

Indexed keywords

CLOPIDOGREL;

ACUTE CORONARY SYNDROME; ADULT; AGED; ARTICLE; BLEEDING; BLOOD TRANSFUSION; CONTROLLED STUDY; CORONARY ARTERY BYPASS GRAFT; DRUG EXPOSURE; DRUG USE; FEMALE; HEART MUSCLE REVASCULARIZATION; HUMAN; LENGTH OF STAY; LOGISTIC REGRESSION ANALYSIS; MAJOR CLINICAL STUDY; MALE; MORBIDITY; OFF PUMP CORONARY SURGERY; ON PUMP CORONARY ARTERY BYPASS; OUTCOME ASSESSMENT; PREOPERATIVE CARE; PRIORITY JOURNAL; REOPERATION; RETROSPECTIVE STUDY; SCORING SYSTEM;

ACUTE CORONARY SYNDROME; AGED; CORONARY ARTERY BYPASS, OFF-PUMP; FEMALE; HEMORRHAGE; HUMANS; LENGTH OF STAY; LOGISTIC MODELS; MALE; MIDDLE AGED; PLATELET AGGREGATION INHIBITORS; PREOPERATIVE CARE; RETROSPECTIVE STUDIES; RISK FACTORS; TICLOPIDINE;

EID: 84862755761     PISSN: 09295305     EISSN: 1573742X     Source Type: Journal    
DOI: 10.1007/s11239-012-0694-x     Document Type: Article

References (25)

1. Kushner F, Hand M, Smith S, King S, Anderson J et al (2009) 2009 Focused updates: ACC/AHA guidelines for the management of patients with ST-elevation myocardial infarction (Updating the 2004 Guideline and 2007 Focused Update) and ACC/AHA/SCAI Guidelines on Percutaneous Coronary Intervention (Updating the 2005 Guideline and 2007 Focused Update): a report of the American College of Cardiology Foundation/American Heart Association Task Force on Practice Guidelines. Circulation 120:2271-2306
2. Ferraris VA, Ferraris SP, Saha SP, Hessel EA II, Haan CK, Royston BD et al, for the Society of Thoracic Surgeons Blood Conservation Task Force (2007) Perioperative blood transfusion and blood conservation in cardiac surgery: The Society of Thoracic Surgeons and the Society of Cardiovascular Anesthesiologists Clinical Practice Guideline. Ann Thorac Surg 83(suppl 5):s27-s86
3. JS Berger CB Frye Q Harshaw FH Edwards SR Steinhubl RC Becker 2008 Impact of clopidogrel in patients with acute coronary syndromes requiring coronary artery bypass surgery: a multicenter analysis J Am Coll Cardiol 52 1693 1701 19007688 10.1016/j.jacc.2008.08.031 1:CAS:528:DC%2BD1cXhtlyktLzJ
4. R Ascione S Williams CT Lloyd T Sundaramoorthi AA Pitsis GD Angelini 2005 Reduced postoperative blood loss and transfusion requirement after beating-heart coronary operations: a prospective randomized study J Thorac Cardiovasc Surg 121 689 696 10.1067/mtc.2001.112823
5. Kobayashi J, Tashiro T, Ochi M, Yaku H, Watanabe G, Satoh T et al (2005) Early outcome of a randomized comparison of off-pump and on-pump multiple arterial coronary revascularization. Circulation 112(9 Suppl):I-338-I-343
6. JD Puskas WH Williams PG Duke JR Staples KE Glas JJ Marshall, et al. 2003 Off-pump coronary artery bypass grafting provides complete revascularization with reduced myocardial injury, transfusion requirements, and length of stay: a prospective randomized comparison of two hundred unselected patients undergoing off-pump versus conventional coronary artery bypass grafting J Thorac Cardiovasc Surg 125 797 808 12698142 10.1067/mtc.2003.324 1:STN:280:DC%2BD3s7nvFWqtg%3D%3D
7. GJ Despotis MS Avidan CW Hogue Jr 2001 Mechanisms and attenuation of hemostatic activation during extracorporeal circulation Ann Thorac Surg 72 S1821 S1831 11722116 10.1016/S0003-4975(01)03211-8 1:STN:280:DC%2BD3Mnns1ensA%3D%3D
8. BM Matata AW Sosnowski M Galiñanes 2000 Off-pump bypass graft operation significantly reduces oxidative stress and inflammation Ann Thorac Surg 69 785 791 10750762 10.1016/S0003-4975(99)01420-4 1:STN:280: DC%2BD3c3ht1yjsg%3D%3D
9. LA Brasil WJ Gomes R Salomão E Buffolo 1998 Inflammatory response after myocardial revascularization with or without cardiopulmonary bypass Ann Thorac Surg 66 56 59 9692438 10.1016/S0003-4975(98)00181-7 1:STN:280: DyaK1czlsFWltA%3D%3D
10. J Vedin A Antovic A Ericsson J Vaage 2005 Hemostasis in off-pump compared to on-pump coronary artery bypass grafting: a prospective, randomized study Ann Thorac Surg 80 586 593 16039210 10.1016/j.athoracsur.2005.02.036
11. TL Frankel SC Stamou SR Lowery EI Kapetanakis PC Hill E Haile PJ Corso 2005 Risk factors for hemorrhage-related reexploration and blood transfusion after conventional versus coronary revascularization without cardiopulmonary bypass Eur J Cardio-Thorac Surg 27 494 500 10.1016/j.ejcts.2004.11.021
12. JK Shim YS Choi YJ Oh SO Bang KJ Yoo YL Kwak 2007 Effects of preoperative aspirin and clopidogrel therapy on perioperative blood loss and blood transfusion requirements in patients undergoing off-pump coronary artery bypass graft surgery J Thorac Cardiovasc Surg 134 59 64 17599487 10.1016/j.jtcvs.2007. 03.013 1:CAS:528:DC%2BD2sXos12it7Y%3D
13. EI Kapetanakis DA Medlam KR Petro E Haile PC Hill MK Dullum, et al. 2006 Effect of clopidogrel premedication in off-pump cardiac surgery: are we forfeiting the benefits of reduced hemorrhagic sequelae? Circulation 113 1667 1674 16567570 10.1161/CIRCULATIONAHA.105.571828 1:CAS:528:DC%2BD28XivVenuro%3D
14. YJ Woo T Grand N Valettas 2005 Off-pump coronary artery bypass grafting attenuates postoperative bleeding associated with preoperative clopidogrel administration Heart Surg Forum 6 282 285
15. S Maltais K Tetreault Q-B Do 2005 Effects of clopidogrel in off-pump beating heart surgery Chest 128 273S 10.1378/chest.128.3.1168
16. K Skelding PB Berger 2006 Does clopidogrel pretreatment counteract the benefits of off-pump CABG surgery? Nat Clin Pract Cardiovasc Med 3 530 531 16990834 10.1038/ncpcardio0652
17. RH Hongo J Ley SE Dick RR Yee 2002 The effect of clopidogrel in combination with aspirin when given before coronary artery bypass grafting J Am Coll Cardiol 40 231 237 12106925 10.1016/S0735-1097(02)01954-X 1:CAS:528:DC%2BD38XmtVSlurw%3D
18. EI Kapetanakis DA Medlam SW Boyce E Haile PC Hill MK Dullum, et al. 2005 Clopidogrel administration prior to coronary artery bypass grafting surgery: the cardiologist's panacea or the surgeon's headache? Eur Heart J 26 576 583 15723815 10.1093/eurheartj/ehi074 1:CAS:528:DC%2BD2MXksFCnsrc%3D
19. Mehta RH, Roe MT, Mulgund J, Ohman EM, Cannon CP, Gibler WB et al (2006) Acute clopidogrel use and outcomes in patients with non-ST-segment elevation acute coronary syndromes undergoing coronary artery bypass surgery. J Am Coll Cardiol 48(2):281-286
20. C von Heymann U Redlich M Moritz M Sander O Vargas Hein H Grubitzsch, et al. 2005 Aspirin and clopidogrel taken until 2 days prior to coronary artery bypass graft surgery is associated with increased postoperative drainage loss Thorac Cardiovasc Surg 53 341 345 10.1055/s-2005-865760
21. F Filsoufi PB Rahmanian JG Castillo RA Kahn G Fischer DH Adams 2008 Clopidogrel treatment before coronary artery bypass graft surgery increases postoperative morbidity and blood product requirements J Cardiothorac Vasc Anesth 22 60 66 18249332 10.1053/j.jvca.2007.10.009 1:CAS:528: DC%2BD1cXjt1yltL4%3D
22. Z Straka P Widimsky K Jirasek P Stros J Votava T Vanek, et al. 2004 Off-pump versus on-pump coronary surgery: final results from a prospective randomized study PRAGUE-4 Ann Thorac Surg 77 789 793 14992872 10.1016/j.athoracsur.2003.08.039
23. SG Raja Z Haider M Ahmad 2003 Predictors of gastrointestinal complications after conventional and beating heart coronary surgery Surgeon 1 221 228 15570766 10.1016/S1479-666X(03)80021-5 1:STN:280:DC%2BD2crpslaqtQ%3D%3D
24. Schulman S, Angeras U, Bergqvist D, Eriksson B, Lassen MR, Fisher W, on behalf of the Subcommittee on Control of Anticoagulation of the Scientific and Standardization Committee of the International Society on Thrombosis and Haemostasis (2010) Definition of major bleeding in clinical investigations of antihemostatic medicinal products in surgical patients. J Thromb Haemost 8:202-204
25. AL Shroyer FL Grover B Hattler JF Collins GO McDonald E Kozora, et al. 2009 On-pump versus off-pump coronary-artery bypass surgery N Engl J Med 361 1827 1837 19890125 10.1056/NEJMoa0902905 1:CAS:528:DC%2BD1MXhtlyltbzO