Targeted resuscitation improves coagulation and outcome

Journal of Trauma and Acute Care Surgery

Volumn 72, Issue 4, 2012, Pages 835-843

  Doran, Catherine M ^a,b   Doran, Callie A ^b   Woolley, Tom ^a   Carter, Alun ^b   Male, Keith ^b   Midwinter, Mark J ^a   Mahoney, Peter F ^a   Watts, Sarah ^b   Kirkman, Emrys ^b  

^a QUEEN ELIZABETH HOSPITAL   (United Kingdom)

^b DEFENCE SCIENCE AND TECHNOLOGY LABORATORY   (United Kingdom)

Author keywords

Blast; Coagulation; Hemorrhage; Inflammation; Resuscitation; Trauma

Indexed keywords

INTERLEUKIN 6; OXYGEN;

ANESTHESIA; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTERIAL PRESSURE; ARTICLE; BLAST INJURY; BLEEDING; BLOOD CLOTTING; BLOOD VOLUME; CONTROLLED STUDY; CYTOKINE RELEASE; HEART RATE; HEMATOCRIT; HYPOTENSION; INFLAMMATION; LIVER INJURY; NONHUMAN; OXYGEN EXTRACTION FRACTION; OXYGEN TISSUE LEVEL; PH; PRIORITY JOURNAL; PROTHROMBIN TIME; SHOCK; SURGERY; SURVIVAL TIME; SYSTOLIC ARTERIAL PRESSURE; TISSUE OXYGENATION; ANIMAL; BLOOD; BLOOD CLOTTING DISORDER; DISEASE MODEL; EXSANGUINATION; INJURY; LIVER; METHODOLOGY; RESUSCITATION; SWINE;

ANIMALS; BLAST INJURIES; BLOOD COAGULATION; BLOOD COAGULATION DISORDERS; DISEASE MODELS, ANIMAL; EXSANGUINATION; HYPOTENSION; INTERLEUKIN-6; LIVER; PROTHROMBIN TIME; RESUSCITATION; SWINE; WOUNDS AND INJURIES;

EID: 84862748944     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e318248347b     Document Type: Article

References (33)

1. Champion HR, Bellamy RF, Roberts CP, Leppaniemi A. A profile of combat injury. J Trauma. 2003;54:S13-S19.
2. Cothren CC, Moore EE, Hedegaard HB, Meng K. Epidemiology of urban trauma deaths: a comprehensive reassessment 10 years later. World J Surg. 2007;31:1507-1511.
3. Brohi K, Singh J, Heron M, Coats T. Acute traumatic coagulopathy. J Trauma. 2003;54:1127-1130.
4. Spahn DR. Hypocalcemia in trauma: frequent but frequently undetected and underestimated. Crit Care Med. 2005;33:2124-2125.
5. Kashuk JL, Moore EE, Sawyer M, et al. Postinjury coagulopathy management: goal directed resuscitation via POC thromboelastography. Ann Surg. 2010;251:604-614.
6. Curry N, Stanworth S, Hopewell S, Doree C, Brohi K, Hyde C. Trauma-induced coagulopathy - a review of the systematic reviews: is there sufficient evidence to guide clinical transfusion practice? Transfus Med Rev. 2011;25:217-231 e2.
7. Brohi K, Cohen MJ, Davenport RA. Acute coagulopathy of trauma: mechanism, identification and effect. Curr Opin Crit Care. 2007;13: 680-685.
8. Macleod JBA, Lynn M, McKenney MG, Cohn SM, Murtha M. Early coagulopathy predicts mortality in trauma. J Trauma. 2003;55:39-44.
9. Maegele M, Lefering R, Yucel N, et al. Early coagulopathy in multiple injury: an analysis from the German Trauma Registry on 8724 patients. Injury. 2007;38:298-304.
10. Plotkin AJ, Wade CE, Jenkins DH, et al. A reduction in clot formation rate and strength assessed by thrombelastography is indicative of transfusion requirements in patients with penetrating injuries. J Trauma. 2008;64:S64-S68.
11. Holcomb JB, Jenkins D, Rhee P, et al. Damage control resuscitation: directly addressing the early coagulopathy of trauma [commentary]. J Trauma. 2007;62:307-310.
12. Loveland JA, Boffard KD. Damage control in the abdomen and beyond. Br J Surg. 2004;91:1095-1101.
13. Brohi K, Cohen MJ, Ganter MT, et al. Acute coagulopathy of trauma: hypoperfusion induces systemic anticoagulation and hyperfibrinolysis. J Trauma. 2008;64:1211-1217; discussion 1217.
14. Cohen MJ, Brohi K, Ganter MT, Manley GT, Mackersie RC, Pittet JF. Early coagulopathy after traumatic brain injury: the role of hypoperfusion and the protein C pathway. J Trauma. 2007;63:1254-1261.
15. Brohi K, Cohen MJ, Ganter MT, Matthay MA, Mackersie RC, Pittet JF. Acute traumatic coagulopathy: initiated by hypoperfusion - modulated through the protein C pathway? Ann Surg. 2007;245:812-818.
16. Rossaint R, Bouillon B, Cerny V, et al. Management of bleeding following major trauma: an updated European guideline. Crit Care. 2010;14:R52.
17. National Institute for Clinical Excellence. Pre-Hospital Initiation of Fluid Replacement in Trauma. Technology Appraisal Guidance. London, UK: NICE; 2004:74.
18. Defence Medical Education and Training Agency. Battlefield Advanced Life Support. UK; 2006.
19. Midwinter MJ, Woolley T. Resuscitation and coagulation in the severely injured trauma patient. Philos Trans R Soc Lond B Biol Sci. 2011;366: 192-203.
20. Bilski TR, Baker BC, Grove JR, et al. Battlefield casualties treated at Camp Rhino, Afghanistan: lessons learned. J Trauma. 2003;54:814-821.
21. Kirkman E, Watts S, Cooper G. Blast injury research models. Philos Trans R S Lond B Biol Sci. 2011;366:144-159.
22. Garner J, Watts S, Parry C, Bird J, Cooper G, Kirkman E. Prolonged permissive hypotensive resuscitation is associated with poor outcome in primary blast injury with controlled hemorrhage. Ann Surg. 2010;251: 1131-1139.
23. Garner JP, Watts S, Parry C, Bird J, Kirkman E. Development of a large animal model for investigating resuscitation after blast and hemorrhage. World J Surg. 2009;33:2194-2202.
24. Bickell WH, Wall MJ Jr, Pepe PE, et al. Immediate versus delayed fluid resuscitation for hypotensive patients with penetrating torso injuries. N Engl J Med. 1994;331:1105-1109.
25. Kowalenko T, Stern S, Dronen S, Wang X. Improved outcome with hypotensive resuscitation of uncontrolled hemorrhagic shock in a swine model. J Trauma. 1992;33:349-353; discussion 361-362.
26. Shuja F, Shults C, Duggan M, et al. Development and testing of freeze-dried plasma for the treatment of trauma-associated coagulopathy. J Trauma. 2008;65:975-985.
27. Dong F, Hall CH, Golech SA, et al. Immune effects of resuscitation with HBOC-201, a hemoglobin-based oxygen carrier, in swine with moderately severe hemorrhagic shock from controlled hemorrhage. Shock. 2006;25:50-55.
28. Hess JR, Brohi K, Dutton RP, et al. The coagulopathy of trauma: a review of mechanisms. J Trauma. 2008;65:748-754.
29. Tieu BH, Holcomb JB, Schreiber MA. Coagulopathy: its pathophysiology and treatment in the injured patient. World J Surg. 2007;31:1055-1064.
30. White NJ, Martin EJ, Brophy DF, Ward KR. Coagulopathy and traumatic shock: characterizing hemostatic function during the critical period prior to fluid resuscitation. Resuscitation. 2010;81:111-116.
31. Watters JM, Tieu BH, Todd SR, et al. Fluid resuscitation increases inflammatory gene transcription after traumatic injury. J Trauma. 2006; 61:300-308; discussion 308-309.
32. Molina PE, Malek S, Lang CH, Qian L, Naukam R, Abumrad NN. Early organ-specific hemorrhage-induced increases in tissue cytokine content: associated neurohormonal and opioid alterations. Neuroimmunomodulation. 1997;4:28-36.
33. Tsukamoto T, Chanthaphavong RS, Pape HC. Current theories on the pathophysiology of multiple organ failure after trauma. Injury. 2010;41: 21-26.