Sp 2-iminosugar O-, S-, and N-glycosides as conformational mimics of α-linked disaccharides; Implications for glycosidase inhibition

Chemistry - A European Journal

Volumn 18, Issue 27, 2012, Pages 8527-8539

  Sánchez Fernández, Elena M ^a   Rísquez Cuadro, Rocío ^b   Ortiz Mellet, Carmen ^b   García Fernández, José M ^a   Nieto, Pedro M ^a   Angulo, Jesús ^a  

^a INSTITUTO DE INVESTIGACIONES QUÍMICAS   (Spain)

^b UNIVERSITY OF SEVILLE   (Spain)

Author keywords

carbohydrates; conformation analysis; inhibitors; molecular modeling; structural biology

Indexed keywords

AGLYCONES; ANOMERIC EFFECT; CONFORMATION ANALYSIS; CONFORMATIONAL ANALYSIS; CONFORMATIONAL ASPECTS; CONFORMATIONAL BEHAVIOR; CONFORMATIONAL PROPERTIES; CONFORMATIONAL SPACE; GLUCOPYRANOSIDE; GLYCOSIDASE INHIBITION; GLYCOSIDASES; GLYCOSIDIC LINKAGES; GLYCOSYLATION REACTIONS; HETEROATOMS; IMINOSUGARS; MIMETICS; N-LINKED; O-LINKED; POTENT INHIBITOR; PROTECTING GROUP; SELECTIVE INHIBITORS; STRUCTURAL BIOLOGY; STRUCTURAL FEATURE;

CARBOHYDRATES; CORROSION INHIBITORS; ENZYMES; MALTOSE; MOLECULAR MODELING; OLIGOSACCHARIDES;

CONFORMATIONS;

ALPHA GLUCOSIDASE; IMINOSUGAR; ISOMALTOSE; MALTOSE;

ARTICLE; CHEMICAL STRUCTURE; CHEMISTRY; DRUG ANTAGONISM; METABOLISM; NUCLEAR MAGNETIC RESONANCE; SYNTHESIS;

ALPHA-GLUCOSIDASES; IMINO SUGARS; ISOMALTOSE; MALTOSE; MODELS, MOLECULAR; MOLECULAR STRUCTURE; NUCLEAR MAGNETIC RESONANCE, BIOMOLECULAR;

EID: 84862748354     PISSN: 09476539     EISSN: 15213765     Source Type: Journal    
DOI: 10.1002/chem.201200279     Document Type: Article

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