Development of myeloproliferative disease in 12/15-lipoxygenase deficiency

Blood

Volumn 119, Issue 25, 2012, Pages 6173-6174

  Taylor, Philip R ^a   Heydeck, Dagmar ^b   Jones, Gareth W ^a   Krönke, Gerhard ^c   Funk, Colin D ^d   Knapper, Steven ^a   Adams, Deborah ^a   Kühn, Hartmut ^b   O'Donnell, Valerie B ^a  

^a CARDIFF UNIVERSITY SCHOOL OF MEDICINE   (United Kingdom)

^b CHARITÉ UNIVERSITÄTSMEDIZIN BERLIN   (Germany)

^c UNIVERSITY OF ERLANGEN NUREMBERG   (Germany)

^d QUEEN S UNIVERSITY   (Canada)

Author keywords

[No Author keywords available]

Indexed keywords

BASOPHILIA; BLAST CELL CRISIS; CHRONIC MYELOID LEUKEMIA; ENZYME DEFICIENCY; EOSINOPHIL; HEMATOPOIETIC STEM CELL; LETTER; LEUKOCYTOSIS; LIPOXYGENASE DEFICIENCY; LYMPHOCYTE DEPLETION; MONOCYTOPENIA; MORTALITY; MYELOPROLIFERATIVE DISORDER; NONHUMAN; PRIORITY JOURNAL; SPLENOMEGALY;

EID: 84862743486     PISSN: 00064971     EISSN: 15280020     Source Type: Journal    
DOI: 10.1182/blood-2012-02-410928     Document Type: Letter

References (4)

1. Kinder M, Wei C, Shelat SG, et al. Hematopoietic stem cell function requires 12/15-lipoxygenase-dependent fatty acid metabolism. Blood. 2010;115(24): 5012-5022.
2. Kinder M, Thompson JE, Wei C, et al. Interferon regulatory factor-8-driven myeloid differentiation is regulated by 12/15-lipoxygenase- mediated redox signaling. Exp Hematol. 2010;38(11):1036-1046.e1-e4.
3. Middleton MK, Zukas AM, Rubinstein T, et al. Identification of 12/15-lipoxygenase as a suppressor of myeloproliferative disease. J Exp Med. 2006; 203(11):2529-2540. (Pubitemid 44664622)
4. Sun D, Funk CD. Disruption of 12/15-lipoxygenase expression in peritoneal macrophages. Enhanced utilization of the 5-lipoxygenase pathway and diminished oxidation of low density lipoprotein. J Biol Chem. 1996;271(39):24055-24062. (Pubitemid 26327385)