A class of Monte-Carlo-based statistical algorithms for efficient detection of repolarization alternans

IEEE Transactions on Biomedical Engineering

Volumn 59, Issue 7, 2012, Pages 1882-1891

  Iravanian, Shahriar ^a,b   Kanu, Uche B ^c   Christini, David J ^c  

^a EMORY UNIVERSITY SCHOOL OF MEDICINE   (United States)

^b KAISER PERMANENTE MEDICAL CENTER   (United States)

^c WEILL CORNELL MEDICAL COLLEGE   (United States)

Author keywords

Alternans; biomedical signal processing; medical signal detection; pacemakers

Indexed keywords

ACTION POTENTIAL DURATIONS; ACTION POTENTIAL WAVEFORMS; ALTERNANS; BEAT-TO-BEAT FLUCTUATIONS; BIOMEDICAL SIGNAL PROCESSING; CARDIAC DEATH; CONTROL EXPERIMENTS; DETECTION ALGORITHM; DETECTION METHODS; EFFICIENT DETECTION; EXPERIMENTAL APPLICATION; GAUSSIANS; GENERALIZED LIKELIHOOD RATIO TEST; IMPLANTABLE CARDIAC DEVICES; LAPLACIANS; LOW COMPLEXITY; OPTICAL MAPPING; QUANTITATIVE MEASUREMENT; REPOLARIZATION ALTERNANS; SPECTRAL METHODS; STATISTICAL ALGORITHM;

EXPERIMENTS; HEART; MONTE CARLO METHODS; PACEMAKERS; SIGNAL DETECTION;

ALGORITHMS;

ALGORITHM; ARTICLE; CARDIAC REPOLARIZATION ALTERNAN; CARDIOVASCULAR PARAMETERS; HEART ELECTROPHYSIOLOGY; HEART MUSCLE POTENTIAL; HEART REPOLARIZATION; KERNEL METHOD; MONTE CARLO METHOD; PACEMAKER; SIGNAL DETECTION; T WAVE;

ACTION POTENTIALS; ALGORITHMS; ARRHYTHMIAS, CARDIAC; COMPUTER SIMULATION; ELECTROCARDIOGRAPHY; HUMANS; MONTE CARLO METHOD; ROC CURVE; SIGNAL PROCESSING, COMPUTER-ASSISTED;

EID: 84862740890     PISSN: 00189294     EISSN: 15582531     Source Type: Journal    
DOI: 10.1109/TBME.2012.2192733     Document Type: Article

References (46)

1. A. Armoundas, M. Osaka, T. Mela, D. S. Rosenbaum, J. N. Ruskin, H. Garan, and R. J. Cohen, "T-wave alternans and dispersion of the QT interval as risk stratification markers in patients susceptible to sustained ventricular arrhythmias," Amer. J. Card., vol. 82, no. 9, pp. 1127-1129, Nov. 1998.
2. M. Gold, D. Bloomfield, K. Anderson, N, El-Sherif, D. J. Wilber, W. J. Groh, N. A. Estes, E. S. Kaufman, M. L. Greenberg, and D. S. Rosenbaum, "A comparison of T-wave alternans, signal averaged electrocardiography and programmed ventricular stimulation for arrhythmia risk stratification," J. Amer. College Card., vol. 36, no. 7, pp. 2247-2253, 2000.
3. S. Hohnloser, T. Klingenheben, Y. Li, M. Zabel, J. Peetermans, and R. J. Cohen, "T wave alternans as a predictor of recurrent ventricular tachyarrhythmias in ICD recipients: Prospective comparison with conventional risk markers," J. Card. Electrophys., vol. 9, pp. 1258-1268, 1998. (Pubitemid 28565123)
4. T. Klingenheben, M. Zabel, R. D'Agostino, R. J. Cohen, and S. H. Hohnloser, "Predictive value of T-wave alternans for arrhythmic events in patients with congestive heart failure," Lancet, vol. 356, no. 9230, pp. 651-652, Aug. 2000. (Pubitemid 30627594)
5. D. Rosenbaum, L. Jackson, J. Smith, H. Garan, J. N. Ruskin, and R. J. Cohen, "Electrical alternans and vulnerability to ventricular arrhythmias,"New Engl. J. Med., vol. 330, no. 4, pp. 235-241, Jan. 1994. (Pubitemid 24034135)
6. M. Chinushi, D. Kozhevnikov, E. B. Caref, M. Restivo, and N. El-Sherif, "Mechanism of discordant T wave alternans in the in vivo heart," J. Card. Electrophys., vol. 14, no. 6, pp. 632-638, Jun. 2003. (Pubitemid 36724389)
7. M. Chinushi, M. Restivo, E. B. Caref, and N. El-Sherif, "Electrophysiological basis of arrhythmogenicity of QT/T alternans in the long-QT syndrome: Tridimensional analysis of the kinetics of cardiac repolarization,"Circulat. Res., vol. 83, no. 6, pp. 614-628, Sep. 1998. (Pubitemid 28427745)
8. W. Shimizu and C. Antzelevitch, "Cellular and ionic basis for T-wave alternans under long-QT conditions," Circulation, vol. 99, no. 11, pp. 1499-1507, Mar. 1999. (Pubitemid 29140918)
9. N. El-Sherif, G. Turitto, R. P. Pedalino, and D. Robotis, "T-wave alternans and arrhythmia risk stratification," Ann. Noninvas. Electrocard., vol. 6, no. 4, pp. 323-332, Oct. 2001. (Pubitemid 33043685)
10. T. Chow, D. J. Kereiakes, C. Bartone, T. Booth, E. Schloss, T. Waller, E. Chung, S. Menon, B. Nallamothu, and P. S. Chan, "Prognostic utility of microvolt T-wave alternans in risk stratification of patients with ischemic cardiomyopathy," J. Amer. College Card., vol. 47, no. 9, pp. 1820-1827, May 2006. (Pubitemid 44308234)
11. G. Turitto, E. B. Caref, G. El-Attar, M. Helal, A. Mohamed, R. Pedalino, and N. El-Sherif, "Optimal target heart rate for exercise-induced T-wave alternans," Ann. Noninvas. Electrocardiol., vol. 6, no. 2, pp. 123-128, Apr. 2001. (Pubitemid 32423398)
12. D. M. Bloomfield, T. Bigger, R. C. Steinman, P. Namerow, M. Parides, A. B. Curtis, E. S. Kaufman, J. Davidenko, T. Shinn, and J. Fontaine, "Microvolt T-wave alternans and the risk of death or sustained ventricular arrhythmias in patients with left ventricular dysfunction," J. Amer. College Cardiol., vol. 47, no. 2, pp. 456-463, Jan. 2006. (Pubitemid 43063271)
13. R. L. Verrier, K. Kumar, and B. D. Nearing, "Basis for sudden cardiac death prediction by T-wave alternans from an integrative physiology perspective,"Heart Rhythm, vol. 6, no. 3, pp. 416-422, Mar. 2009.
14. R. L. Verrier, B. D. Nearing, and K. F. Kwaku, "Noninvasive sudden death risk stratification by ambulatory ECG-based T-wave alternans analysis: Evidence and methodological guidelines," Ann. Noninvas. Electrocardiol., vol. 10, no. 1, pp. 110-120, Jan. 2005.
15. S. M. Narayan, "T-Wave alternans and the susceptibility to ventricular arrhythmias," J. Amer. College Cardiol., vol. 47, no. 2, pp. 269-281, Jan. 2006.
16. S. M. Narayan, "T-wave alternans testing for ventricular arrhythmias,"Progr. Cardiovasc. Diseases, vol. 51, no. 2, pp. 118-127, Sep. 2011.
17. S. M. Narayan, M. R. Franz, P. Clopton, E. J. Pruvot, and D. E. Krummen, "Repolarization alternans reveals vulnerability to human atrial fibrillation,"Circulation, vol. 123, pp. 2922-2930, Jun. 2011.
18. L. Burattini and W. Zareba, "Time-domain analysis of beat-to-beat variability of repolarization morphology in patients with ischemic cardiomyopathy,"J. Electrocardiol., vol. 32, pp. 166-172, Jan. 1999. (Pubitemid 30100123)
19. L. Burattini, W. Zareba, and R. Burattini, "Adaptive match filter based method for time vs. amplitude characterization of microvolt ECG T-wave alternans," Ann. Biomed. Eng., vol. 36, no. 9, pp. 1558-1564, Sep. 2008.
20. P. Laguna, G. B.Moody, J. Garca, A. Goldberger, and R. Mark, "Analysis of the ST-T complex of the electrocardiogram using the Karhunen-Love transform: Adaptive monitoring and alternans detection," Med. Biol. Eng. Comput., vol. 37, no. 2, pp. 175-189, Mar. 1999. (Pubitemid 29131288)
21. J. M. Smith, E.A.Clancy,C.R.Valeri, J. Ruskin, and R. Cohen, "Electrical alternans and cardiac electrical instability," Circulation, vol. 77, no. 1, pp. 110-121, Jan. 1988.
22. P. Strumillo and J. Ruta, "Poincar mapping for detecting abnormal dynamics of cardiac repolarization," IEEE Eng. Med. Biol. Mag., vol. 21, no. 1, pp. 62-65, Jan. 2002. (Pubitemid 34263920)
23. A. Maybhate, S. C. Hao, S. Iwai, J. U. Lee, A. B. Guttigoli, K. M. Stein, B. B. Lerman, and D. J. Christini, "Detection of repolarization alternans with an implantable cardioverter defibrillator lead in a porcine model,"IEEE Trans. Biol. Eng., vol. 52, no. 7, pp. 1188-1194, Jul. 2005. (Pubitemid 40961369)
24. J. P. Martinez and S. Olmos, "Methodological principles of T wave alternans analysis: A unified framework," IEEE Trans. Biomed. Eng, vol. 52, no. 4, pp. 599-613, Apr. 2005. (Pubitemid 40477170)
25. J. Pastore, S. Girouard, K. Laurita, F. Akar, and D. S. Rosenbaum, "Mechanism linking T-wave alternans to the genesis of cardiac fibrillation,"Circulation, vol. 99, no. 10, pp. 1385-1394, 1999. (Pubitemid 29129926)
26. J. Fox, M. Riccio, F. Hua, E. Bodenschatz, and R. F. Gilmour Jr., "Spatiotemporal transition to conduction block in canine ventricle," Circulat. Res., vol. 90, no. 3, pp. 289-296, Jan. 2002. (Pubitemid 34633930)
27. J. Pastore and D. Rosenbaum, "Role of structural barriers in the mechanism of alternans-induced reentry," Circulat. Res., vol. 87, no. 12, pp. 1157-1163, 2000.
28. G. Hall and D. Gauthier, "Experimental control of cardiac muscle alternans,"Phys. Rev. Lett., vol. 88, no. 19, 198102, Apr. 2002.
29. S. Gaeta, G. Bub, G. Abbott, and D. J. Christini, "Dynamical mechanism for subcellular alternans in cardiac myocytes," Circulat. Res., vol. 105, pp. 335-342, Jul. 2009.
30. U. B. Kanu, S. Iravanian, R. F. Gilmour, and D. J. Christini, "Control of action potential duration alternans in canine cardiac ventricular tissue,"IEEE Trans. Biomed. Eng., vol. 58, no. 4, pp. 894-904, Apr. 2011.
31. P. N. Jordan and D. J. Christini, "Adaptive diastolic interval control of cardiac action potential duration alternans," J. Cardiovasc. Electrophysiol., vol. 10, pp. 1177-1185, Oct. 2004.
32. D. Christini, M. Riccio, C. Culianu, J. Fox, A. Karma, and R. F. Gilmour, Jr., "Control of electrical alternans in canine cardiac purkinje fibers,"Phys. Rev. Lett., vol. 96, no. 10, 104101, 2006.
33. Z. Jia, H. Bien, and E. Entcheva, "Detecting space-time alternating biological signals close to the bifurcation point," IEEE Trans. Biomed. Eng., vol. 57, no. 2, pp. 316-324, Feb. 2010.
34. D. J. Christini and B. B. Lerman, "Implantable cardioverter- defibrillator detection of repolarization alternans: Uncovering a marker of electrical instability," Heart Rhythm, vol. 3, no. 7, pp. 798-799, Jul. 2006.
35. S. Nemati, O. Abdala, V. Monasterio, S. Yim-Yeh, A. Malhotra, and G. D. Clifford, "A nonparametric surrogate-based test of significance for T-wave alternans detection," IEEE Trans. Biomed. Eng., vol. 58, no. 5, pp. 1356-1364, May 2011.
36. F. C. Leone, R. B. Nottingham, and L. S. Nelson, "The folded normal distribution," Technometrics, vol. 3, no. 4, pp. 543-550, 1961.
37. D. E. Knuth, The Art of Computer Programming: Seminumerical Algorithms. vol. 2, Reading, MA: Addison-Wesley, 1969, pp. 124-125.
38. J. P. Martinez and S. Olmos, "Detection of T wave alternans in nonstationary noise: A GLRT approach," Comput. Cardiol., vol. 30, pp. 161-164, Sep. 2003.
39. J. P. Martinez and S. Olmos, "A robust T wave alternans detector based on the GLRT for Laplacian noise distribution," Comput. Cardiol., vol. 29, pp. 677-680, Sep. 2002.
40. "Electrocardiogram (ECG) Signal Processing," in Wiley Encyclopedia of Biomedical Engineering, vol. 2, M. Akay, Ed. New York: Wiley, Apr. 2006, pp. 1298-1313.
41. V. Monasterio, P. Laguna, and J. P. Martinez, "A multilead scheme based on periodic component analysis for Twave alternans analysis in the ECG,"Ann. Biomed. Eng., vol. 38, no. 8, pp. 2532-2541, Aug. 2010.
42. Z. Qu, A. Garfinkel, P. S. Chen, and J.Weiss, "Mechanisms of discordant alternans and induction of reentry in simulated cardiac tissue," Circulation, vol. 102, no. 14, pp. 1664-1670, Oct. 2000.
43. M. A.Watanabe, F. H. Fenton, S. J. Evans, H. M. Hastings, and A. Karma, "Mechanisms for discordant alternans," J. Cardiovasc. Electrophysiol., vol. 12, no. 2, pp. 196-206, Feb. 2001.
44. H. Hayashi, Y. Shiferaw, D. Sato, M. Nihei, S.-F. Lin, P.-S. Chen, A. Garfinkel, J. N.Weiss, and Z. Qu, "Dynamic origin of spatially discordant alternans in cardiac tissue," Biophys. J., vol. 92, no. 2, pp. 448-460, Jan. 2007. (Pubitemid 46145778)
45. F. X. Witkowski, L. J. Leon, P. A. Penkoske, W. R. Giles, M. L. Spano, W. L. Ditto, and A. T. Winfree, "Spatiotemporal evolution of ventricular fibrillation," Nature, vol. 392, no. 6671, pp. 78-82, Mar. 1998.
46. A. Karma, "Electrical alternans and spiralwave breakup in cardiac tissue,"Chaos: Interdiscipl. J. Nonlinear Sci., vol. 4, pp. 461-472, Sep. 1994.