An Assessment of the Ocular Safety of Excipient Maleic Acid Following Intravitreal Injection in Rabbits

Toxicologic Pathology

Volumn 40, Issue 5, 2012, Pages 797-806

  Aguirre, Shirley A ^a   Collette, Walter ^a   Gukasyan, Hovhannes J ^b   Huang, Wenhu ^a  

^a PFIZER INC   (United States)

^b Pharmaceutical Sciences Drug Product Development Research Support Group   (United States)

Author keywords

excipients; formulations; funduscopy; intravitreal; maleic acid; ocular; safety

Indexed keywords

MALEIC ACID; SODIUM CHLORIDE;

ANIMAL EXPERIMENT; ANTERIOR EYE CHAMBER; ARTICLE; CHEMOSIS; CLINICAL ASSESSMENT; CONJUNCTIVA DISEASE; CONJUNCTIVA FIBROSIS; CONJUNCTIVITIS; CONTROLLED STUDY; DRUG BLOOD LEVEL; DRUG FORMULATION; DRUG INJECTION VOLUME; DRUG SAFETY; DRUG TOLERABILITY; EYE; EYE IRRITATION; EYE TOXICITY; FEMALE; HISTOPATHOLOGY; NERVE DEGENERATION; NONHUMAN; OPHTHALMOSCOPY; OPTIC NERVE DEMYELINATION; OPTIC NERVE DISEASE; PH; PRIORITY JOURNAL; RABBIT; RETINA DEGENERATION; RETINA DISCOLORATION; RETINA DISEASE; RETINA FOLD; RETINA PIGMENT EPITHELIOPATHY; SCLERA DISEASE; VITREOUS BODY;

ANIMALS; ANTERIOR CHAMBER; DOSE-RESPONSE RELATIONSHIP, DRUG; DRUG EVALUATION, PRECLINICAL; EXCIPIENTS; EYE; FEMALE; INTRAOCULAR PRESSURE; INTRAVITREAL INJECTIONS; MALEATES; OPHTHALMOSCOPY; RABBITS; RETINA; RETINAL DISEASES; RISK ASSESSMENT; VISION, OCULAR;

EID: 84862739142     PISSN: 01926233     EISSN: 15331601     Source Type: Journal    
DOI: 10.1177/0192623312441400     Document Type: Article

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