-
1
-
-
33947712686
-
Stratified medicine: Strategic and economic implications of combining drugs and clinical biomarkers
-
Trusheim MR, Berndt ER, Douglas FL. Stratified medicine: strategic and economic implications of combining drugs and clinical biomarkers. Nat. Rev. Drug Disc. 6, 287-293 (2007).
-
(2007)
Nat. Rev. Drug Disc.
, vol.6
, pp. 287-293
-
-
Trusheim, M.R.1
Berndt, E.R.2
Douglas, F.L.3
-
2
-
-
48249123433
-
Pharmacogenic biomarker information in drug labels approved by the United States Food and Drug Administration: Prevalence of related drug use
-
Frueh FW, Amur S, Mummaneni P et al. Pharmacogenic biomarker information in drug labels approved by the United States Food and Drug Administration: prevalence of related drug use. Pharmacotherapy 28(8), 992-998 (2008).
-
(2008)
Pharmacotherapy
, vol.28
, Issue.8
, pp. 992-998
-
-
Frueh, F.W.1
Amur, S.2
Mummaneni, P.3
-
3
-
-
33846646004
-
The prospects for 'personalized medicine' in drug development and drug therapy
-
Woodcock J. The prospects for 'personalized medicine' in drug development and drug therapy. Clin. Pharmacol. Ther. 81, 164-169 (2007).
-
(2007)
Clin. Pharmacol. Ther.
, vol.81
, pp. 164-169
-
-
Woodcock, J.1
-
4
-
-
80155150460
-
Quantifying stratified medicine success factors: A multi-stakeholder perspective
-
US FDA, academic and industry consortium modeling analysis of the critical drivers affecting the economics of developing stratified medicines. It includes one CNS and two oncology case studies
-
Trusheim MR, Burgess B, Xinghua Hu S et al. Quantifying stratified medicine success factors: a multi-stakeholder perspective. Nat. Rev. Drug Disc. 10(11), 817-833 (2011). US FDA, academic and industry consortium modeling analysis of the critical drivers affecting the economics of developing stratified medicines. It includes one CNS and two oncology case studies.
-
(2011)
Nat. Rev. Drug Disc.
, vol.10
, Issue.11
, pp. 817-833
-
-
Trusheim, M.R.1
Burgess, B.2
Xinghua Hu, S.3
-
5
-
-
84862748550
-
-
Institute of Medicine. The National Academies Press Washington, DC, USA Multistakeholder, independent review of the challenges and costs of developing stratified medicines in oncology with potential policy implications
-
Institute of Medicine. Policy Issues in the Development of Personalized Medicine in Oncology: Workshop Summary. The National Academies Press Washington, DC, USA (2010). Multistakeholder, independent review of the challenges and costs of developing stratified medicines in oncology with potential policy implications.
-
(2010)
Policy Issues in the Development of Personalized Medicine in Oncology: Workshop Summary
-
-
-
6
-
-
0032445260
-
HER-2/ neu as a predictive marker of response to breast cancer therapy
-
Pegram MD, Pauletti G, Slamon DJ. HER-2/ neu as a predictive marker of response to breast cancer therapy. Breast Cancer Res. Treat. 52(1-3), 65-77 (1998).
-
(1998)
Breast Cancer Res. Treat.
, vol.52
, Issue.1-3
, pp. 65-77
-
-
Pegram, M.D.1
Pauletti, G.2
Slamon, D.J.3
-
7
-
-
40849118803
-
Analysis of KRAS mutations in patients with metastatic colorectal cancer receiving panitumumab monotherapy
-
Amodol RG, Wolf M, Freeman D et al. Analysis of KRAS mutations in patients with metastatic colorectal cancer receiving panitumumab monotherapy. Eur. J. Cancer Suppl. 5, 8 (2007).
-
(2007)
Eur. J. Cancer Suppl.
, vol.5
, pp. 8
-
-
Amodol, R.G.1
Wolf, M.2
Freeman, D.3
-
8
-
-
33846995628
-
Economics of new oncology drug development
-
An analysis of the reduction in oncology patient populations for any individual medicine due to the scientific molecular segmentation of the disease and the number of targeted therapies
-
DiMasi JA, Grabowski HG. Economics of new oncology drug development. J. Clin. Oncol. 25(2), 209-216 (2007). An analysis of the reduction in oncology patient populations for any individual medicine due to the scientific molecular segmentation of the disease and the number of targeted therapies.
-
(2007)
J. Clin. Oncol.
, vol.25
, Issue.2
, pp. 209-216
-
-
DiMasi, J.A.1
Grabowski, H.G.2
-
9
-
-
51049083681
-
-
US Cancer Statistics Working Group. Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute, GA, USA
-
US Cancer Statistics Working Group. United States Cancer Statistics: 1999-2004 Incidence and Mortality Web-Based Report. Department of Health and Human Services, Centers for Disease Control and Prevention and National Cancer Institute, GA, USA (2007).
-
(2007)
United States Cancer Statistics: 1999-2004 Incidence and Mortality Web-Based Report
-
-
-
10
-
-
68249134187
-
How much is life worth: Cetuximab, non-small cell lung cancer, and the $440 billion question
-
An analysis of the combined cost to payers if all oncology personalized medicines command increasingly high prices and obtain widespread usage
-
Fojo T, Grady C. How much is life worth: cetuximab, non-small cell lung cancer, and the $440 billion question. J. Natl Cancer Inst. 101, 1044-1048 (2009). An analysis of the combined cost to payers if all oncology personalized medicines command increasingly high prices and obtain widespread usage.
-
(2009)
J. Natl Cancer Inst.
, vol.101
, pp. 1044-1048
-
-
Fojo, T.1
Grady, C.2
-
11
-
-
82455198979
-
Personalized medicine in oncology: Next generation
-
Chiang A, Million RP. Personalized medicine in oncology: next generation. Nat. Rev. Drug Disc. 10(12), 895-896 (2011).
-
(2011)
Nat. Rev. Drug Disc.
, vol.10
, Issue.12
, pp. 895-896
-
-
Chiang, A.1
Million, R.P.2
-
12
-
-
84862741376
-
Approval for drug that treats melanoma
-
25 March n A description of the recent oncology product launches, including their pricing
-
Pollack A. Approval for drug that treats melanoma. New York Times, 25 March (2011). n A description of the recent oncology product launches, including their pricing.
-
(2011)
New York Times
-
-
Pollack, A.1
-
13
-
-
31044434278
-
The current clinical practice of pharmacogenetic testing in Europe: TPMT and HER2 as case studies
-
Woelderink A, Ibarreta D, Hopkins MM and Rodriguez-Cerezo E. The current clinical practice of pharmacogenetic testing in Europe: TPMT and HER2 as case studies. Pharmacogenomics J. 6, 3-7 (2006).
-
(2006)
Pharmacogenomics J.
, vol.6
, pp. 3-7
-
-
Woelderink, A.1
Ibarreta, D.2
Hopkins, M.M.3
Rodriguez-Cerezo, E.4
-
14
-
-
40949134730
-
EGF-receptor targeting with monoclonal antibodies in colorectal carcinomas: Rationale for a pharmacogenomic approach
-
Loupakis F, Vasile E, Santini D, Masi G, Falcone A, Graziano F. EGF-receptor targeting with monoclonal antibodies in colorectal carcinomas: rationale for a pharmacogenomic approach. Pharmacogenomics 9(1), 55-69 (2008).
-
(2008)
Pharmacogenomics
, vol.9
, Issue.1
, pp. 55-69
-
-
Loupakis, F.1
Vasile, E.2
Santini, D.3
Masi, G.4
Falcone, A.5
Graziano, F.6
-
15
-
-
84862749235
-
GATT brings major changes in U.S. patent law
-
Radack DV. GATT brings major changes in U.S. patent law. JOM 47(5), 79 (1995).
-
(1995)
JOM
, vol.47
, Issue.5
, pp. 79
-
-
Radack, D.V.1
-
16
-
-
79960220632
-
The FDA is evading the law
-
23 December
-
Gottlieb S. The FDA is evading the law. Wall Street Journal, 23 December (2010).
-
(2010)
Wall Street Journal
-
-
Gottlieb, S.1
-
17
-
-
33645680700
-
Developing drugs for developing countries
-
Ridley DA, Grabowski HG, Moe J. Developing drugs for developing countries. Health Affairs 25(2), 313-324 (2006).
-
(2006)
Health Affairs
, vol.25
, Issue.2
, pp. 313-324
-
-
Ridley, D.A.1
Grabowski, H.G.2
Moe, J.3
-
18
-
-
79958130366
-
Opportunities for improving the drug development process: Results from a survey of industry and the FDA
-
Jaffe AB, Lerner J, Stern SM (Eds). MIT Press for the National Bureau of Economic Research, MA, USA
-
Berndt ER, Gottschalk AHB, Strobeck MW. Opportunities for improving the drug development process: results from a survey of industry and the FDA. In: Innovation Policy and the Economy. Jaffe AB, Lerner J, Stern SM (Eds). MIT Press for the National Bureau of Economic Research, MA, USA, 91-121 (2006).
-
(2006)
Innovation Policy and the Economy
, pp. 91-121
-
-
Berndt, E.R.1
Gottschalk, A.H.B.2
Strobeck, M.W.3
-
19
-
-
12344307477
-
A new system for moving drugs to market
-
A compelling case for revising the regulatory approval process to provide faster, appropriate access to emerging therapies and to continue learning about those therapies postapproval
-
Woosley RL, Rice G. A new system for moving drugs to market. Issues Sci. Technol. 21(2), 63-68 (2005). A compelling case for revising the regulatory approval process to provide faster, appropriate access to emerging therapies and to continue learning about those therapies postapproval.
-
(2005)
Issues Sci. Technol.
, vol.21
, Issue.2
, pp. 63-68
-
-
Woosley, R.L.1
Rice, G.2
-
20
-
-
84862777400
-
Adaptive licensing: Taking the next step in the evolution of drug approval
-
Eichler HG, Oye K, Baird LG et al. Adaptive licensing: taking the next step in the evolution of drug approval. Clin. Pharmacol. Ther. 91(3), 426-437 (2012).
-
(2012)
Clin. Pharmacol. Ther.
, vol.91
, Issue.3
, pp. 426-437
-
-
Eichler, H.G.1
Oye, K.2
Baird, L.G.3
-
21
-
-
79953193825
-
Early accelerated approval for highly targeted cancer drugs
-
Chabner BA. Early accelerated approval for highly targeted cancer drugs. N. Engl. J. Med. 364(12), 1087-1089 (2011).
-
(2011)
N. Engl. J. Med.
, vol.364
, Issue.12
, pp. 1087-1089
-
-
Chabner, B.A.1
-
22
-
-
79551609869
-
An accelerated pathway for targeted cancer therapies
-
McClellan M, Benner J, Schlisky R et al. An accelerated pathway for targeted cancer therapies. Nature Rev. Drug Disc. 10(2), 79-80 (2011).
-
(2011)
Nature Rev. Drug Disc.
, vol.10
, Issue.2
, pp. 79-80
-
-
McClellan, M.1
Benner, J.2
Schlisky, R.3
-
23
-
-
84862751214
-
NCATS launches
-
Fox FL. NCATS launches. Nat. Biotechnol. 30, 204 (2012).
-
(2012)
Nat. Biotechnol.
, vol.30
, pp. 204
-
-
Fox, F.L.1
-
24
-
-
20044364409
-
Vaccine advance - Purchase agreements for low-income countries: Practical issues
-
Berndt ER, Hurvitz JA. Vaccine advance - purchase agreements for low-income countries: practical issues. Health Affairs 24(3), 653-665 (2005).
-
(2005)
Health Affairs
, vol.24
, Issue.3
, pp. 653-665
-
-
Berndt, E.R.1
Hurvitz, J.A.2
-
25
-
-
77649116977
-
Incentivizing innovation: Adding to the tool kit
-
Lerner J, Stern SM (Eds). MIT Press for the National Bureau of Economic Research, MA, USA
-
Kremer M and Williams H. Incentivizing innovation: adding to the tool kit. In: Innovation Policy and the Economy. Lerner J, Stern SM (Eds). MIT Press for the National Bureau of Economic Research, MA, USA, 1-17 (2010).
-
(2010)
Innovation Policy and the Economy
, pp. 1-17
-
-
Kremer, M.1
Williams, H.2
-
26
-
-
0037374498
-
The price of innovation: New estimates of drug development costs
-
DiMasi JA, Hansen RW, Grabowski HG. The price of innovation: new estimates of drug development costs. J. Health Econ. 22(2), 141-185 (2003).
-
(2003)
J. Health Econ.
, vol.22
, Issue.2
, pp. 141-185
-
-
DiMasi, J.A.1
Hansen, R.W.2
Grabowski, H.G.3
-
27
-
-
0028895424
-
Research and development costs for new drugs by therapeutic category: A study of the US pharmaceutical industry
-
DiMasi JA, Hansen RW, Grabowski HG, Lasagna L. Research and development costs for new drugs by therapeutic category: a study of the US pharmaceutical industry. Pharmacoeconomics 7, 152-160 (1995).
-
(1995)
Pharmacoeconomics
, vol.7
, pp. 152-160
-
-
DiMasi, J.A.1
Hansen, R.W.2
Grabowski, H.G.3
Lasagna, L.4
-
28
-
-
34548324706
-
The cost of biopharmaceutical R&D: Is biotech different?
-
DiMasi JA, Grabowski HG. The cost of biopharmaceutical R&D: is biotech different? Manage. Decis. Econ. 28, 469-479 (2007).
-
(2007)
Manage. Decis. Econ.
, vol.28
, pp. 469-479
-
-
DiMasi, J.A.1
Grabowski, H.G.2
-
29
-
-
33645675960
-
Estimating the cost of new drug development: Is it really $802 million?
-
Adams CP, Brantner VV. Estimating the cost of new drug development: is it really $802 million? Health Affairs 25(2), 420-428 (2006).
-
(2006)
Health Affairs
, vol.25
, Issue.2
, pp. 420-428
-
-
Adams, C.P.1
Brantner, V.V.2
-
30
-
-
58149186582
-
Do molecularly targeted agents in oncology have reduced attrition rates?
-
Walker I, Newell H. Do molecularly targeted agents in oncology have reduced attrition rates? Nat. Rev. Drug Disc. 8(1), 15-16 (2009).
-
(2009)
Nat. Rev. Drug Disc.
, vol.8
, Issue.1
, pp. 15-16
-
-
Walker, I.1
Newell, H.2
-
32
-
-
33847299170
-
Specialty pharmacy cost management strategies of private health care payers
-
Stern D, Reissman D. Specialty pharmacy cost management strategies of private health care payers. J. Manag. Care Pharm. 12(9), 736-744 (2006).
-
(2006)
J. Manag. Care Pharm.
, vol.12
, Issue.9
, pp. 736-744
-
-
Stern, D.1
Reissman, D.2
-
33
-
-
84862732514
-
US FDA clears Abbott's companion Dx for Pfizer's NSCLC Drug
-
29 August Accessed 6 January 2012
-
US FDA clears Abbott's companion Dx for Pfizer's NSCLC Drug. GenomeWeb Daily News. 29 August 2011. www.genomeweb.com/mdx/fda-clearsabbotts-companion- dx-pfizers-nsclc-drug (Accessed 6 January 2012)
-
(2011)
GenomeWeb Daily News
-
-
-
34
-
-
84930739294
-
US FDA approves Xalkori with companion diagnostic for a type of late-stage lung cancer
-
26 August Accessed 6 January 2012
-
Jefferson E. US FDA approves Xalkori with companion diagnostic for a type of late-stage lung cancer. FDA News Release. 26 August 2011. www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm269856.htm (Accessed 6 January 2012)
-
(2011)
FDA News Release
-
-
Jefferson, E.1
-
35
-
-
84862732515
-
Current experience with stratified medicines & current drugs in development
-
Presented at: Accessed 17 June 2011
-
McHale D. Current experience with stratified medicines & current drugs in development. Presented at: Fifth Forum of the Ministerial Industry Strategy Group (MISG) UK MHRA. 9 October 2009. www.mhra.gov.uk/home/groups/es- policy/documents/websiteresources/con065595.pdf (Accessed 17 June 2011)
-
Fifth Forum of the Ministerial Industry Strategy Group (MISG) UK MHRA. 9 October 2009
-
-
McHale, D.1
-
36
-
-
84857209778
-
-
US Department of Health and Human Services, US FDA. Accessed 1 February 2012
-
US Department of Health and Human Services, US FDA. FY 2011 innovative drug approvals. www.fda.gov/downloads/aboutfda/reportsmanualsforms/reports/ ucm278358.pdf (Accessed 1 February 2012)
-
FY 2011 Innovative Drug Approvals
-
-
-
37
-
-
0003964361
-
-
American Cancer Society No. 500810. 2 Accessed 17 June 2011
-
American Cancer Society. Cancer Facts and Figures 2010. American Cancer Society No. 500810. 2. (2010). www.cancer.org/Research/CancerFactsFigures/ CancerFactsFigures/cancer-facts-and-figures-2010 (Accessed 17 June 2011)
-
(2010)
Cancer Facts and Figures 2010
-
-
-
38
-
-
84862732513
-
$93,000 cancer drug: How much is a life worth?
-
Associated Press. 27 September Accessed 17 June 2011
-
Associated Press. $93,000 cancer drug: how much is a life worth? Boston Herald 27 September 2010. http://news.bostonherald.com/business/ healthcare/view/2010092793000-cancer-drug-how-much-is-a-life-worth/srvc= home&position=recent (Accessed 17 June 2011)
-
(2010)
Boston Herald
-
-
-
39
-
-
84862748555
-
Time to consider cost in evaluating cancer drugs in United States?
-
Accessed 14 June 2011
-
Mucahy N. Time to consider cost in evaluating cancer drugs in United States? Medscape News Today. www.medscape.com/viewarticle/705689 (Accessed 14 June 2011)
-
Medscape News Today
-
-
Mucahy, N.1
-
41
-
-
0003814159
-
Costs and quality of life in multiple sclerosis: A cross-sectional study in the USA
-
Dec Accessed 17 June 2011
-
Kobelt G et al. Costs and quality of life in multiple sclerosis: a cross-sectional study in the USA. SSE/EFI Working Paper Series in Economics and Finance 594 (Dec 2004). http://swopec.hhs.se/hastef/papers/hastef0594.pdf (Accessed 17 June 2011)
-
(2004)
SSE/EFI Working Paper Series in Economics and Finance 594
-
-
Kobelt, G.1
-
42
-
-
84862732517
-
-
Accessed 11 February 2011
-
Recap by Deloitte. www.recap.com (Accessed 11 February 2011)
-
Recap by Deloitte
-
-
-
43
-
-
84862748554
-
Three-year market exclusivity extension for a new indication of a drug
-
Patent Baristas 7 March Accessed 17 June 2011
-
Albainy-Jenei S. Three-year market exclusivity extension for a new indication of a drug. Patent Baristas 7 March 2006. www.patentbaristas.com/ archives/2006/03/07/three-year-marketexclusivity-extension-for-a-new-indication- ofa-drug/ (Accessed 17 June 2011).
-
(2006)
-
-
Albainy-Jenei, S.1
-
46
-
-
84862728535
-
-
S.505, 27 January Accessed 18 December 2010
-
Copyright Term Extension Act of 1998, S.505, 27 January 1998. www.copyright.gov/legislation/s505.pdf (Accessed 18 December 2010)
-
(1998)
Copyright Term Extension Act of 1998
-
-
-
47
-
-
84861232675
-
-
Accessed 17 June 2011
-
US FDA. CFR-Code of Federal Regulations Title 21. www.accessdata.fda.gov/ scripts/cdrh/cfdocs/cfcfr/CFRSearch.cfm?CFRPart=314&showFR= 1&subpartNode=21:5.0.1.1.4.8 (Accessed 17 June 2011).
-
CFR-Code of Federal Regulations Title 21
-
-
-
48
-
-
79952263351
-
-
News release, 8 April Accessed 17 June 2011
-
US FDA. US FDA approves coartem tablets to treat malaria. News release, 8 April 2009. www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm149559.htm (Accessed 17 June 2011)
-
(2009)
US FDA Approves Coartem Tablets to Treat Malaria
-
-
-
53
-
-
84862732518
-
-
13 December Accessed 17 June 2011
-
Glassman A. Break out the champagne! The AMC delivers vaccine. Center for Global Development, 13 December 2010. http://blogs.cgdev.org/globalhealth/2010/ 12/break-out-the-champagne-the-amc-deliversvaccines.phpl (Accessed 17 June 2011)
-
(2010)
Break out the Champagne! The AMC Delivers Vaccine
-
-
Glassman, A.1
-
54
-
-
84862741382
-
-
Mndaily.com 4 April Accessed 17 June 2011
-
Nord J, Lynn K. Pawlenty approves 'angel' tax credit bill. Mndaily.com 4 April 2010. www.mndaily.com/2010/04/04/pawlentyapproves-%E2%80%98angel%E2%80%99- tax-credit-bill (Accessed 17 June 2011)
-
(2010)
Pawlenty Approves 'Angel' Tax Credit Bill
-
-
Nord, J.1
Lynn, K.2
-
55
-
-
84862732521
-
President Obama signs small business jobs act-learn what's in it
-
September 27 Accessed 17 June 2011
-
Lee J. President Obama signs small business jobs act-learn what's in it. 2010 September 27 In: The White House blog. www.whitehouse.gov/blog/2010/09/27/ president-obama-signs-small-business-jobsact-learn-whats-it (Accessed 17 June 2011)
-
(2010)
The White House Blog
-
-
Lee, J.1
-
56
-
-
84862733032
-
-
Unpublished SM thesis, Harvard-MIT Division of Health Sciences and Technology, MA, USA June Accessed 9 January 2012 A Masters thesis demonstrating that despite strong scientific hypotheses, developing a chronic myeloid leukemia medicine for the small drug-resistant population is not economically viable under nearly any current scenario
-
Sterk J. Assessing the impact of tumor evolution on oncology drug development and commercialization. Unpublished SM thesis, Harvard-MIT Division of Health Sciences and Technology, MA, USA (June 2011). http://dspace.mit.edu/ handle/1721.1/65523 (Accessed 9 January 2012) A Masters thesis demonstrating that despite strong scientific hypotheses, developing a chronic myeloid leukemia medicine for the small drug-resistant population is not economically viable under nearly any current scenario.
-
(2011)
Assessing the Impact of Tumor Evolution on Oncology Drug Development and Commercialization
-
-
Sterk, J.1
-
57
-
-
84876923310
-
A quality-adjusted price index for colorectal cancer drugs
-
July Accessed 6 May 2012
-
Lucarelli C, Nicholson S. A quality-adjusted price index for colorectal cancer drugs. NBER Working Paper No. 15174 (July 2009). www.nber.org/papers/ w15174 (Accessed 6 May 2012)
-
(2009)
NBER Working Paper No. 15174
-
-
Lucarelli, C.1
Nicholson, S.2
-
58
-
-
84862733033
-
New model aims to put brakes on rising cost of cancer care
-
October 19, Accessed 17 June 2011
-
Yee CM. New model aims to put brakes on rising cost of cancer care. Minneapolis Star Tribune October 19, 2010. www.startribune.com/business/ 105312318.html?elr=KArksUUUoDEy3LGDiO7ai (Accessed 17 June 2011)
-
(2010)
Minneapolis Star Tribune
-
-
Yee, C.M.1
-
59
-
-
84862748558
-
Bristol-Myers Sprycel Drug Beats Gleevec in Leukemia Patients, Study Says
-
5 June Accessed 17 June 2011
-
Petttypiece S. Bristol-Myers Sprycel Drug Beats Gleevec in Leukemia Patients, Study Says. Bloomberg News (5 June 2010). www.bloomberg.com/news/2010- 2006-05/bristol-myers-sprycel-drug-beats-gleevec-inleukemia-patients-study-says. html (Accessed 17 June 2011)
-
(2010)
Bloomberg News
-
-
Petttypiece, S.1
-
61
-
-
38849155626
-
Research and development in the pharmaceutical industry
-
October Accessed 6 May 2012
-
Austin DH, Kyle J, Moore D. Research and development in the pharmaceutical industry. Congressional Budget Office Pub No. 2589 (October 2006). www.cbo.gov/sites/default/files/cbofiles/ftpdocs/76xx/doc7615/10-02- drugr-d.pdf (Accessed 6 May 2012)
-
(2006)
Congressional Budget Office Pub No. 2589
-
-
Austin, D.H.1
Kyle, J.2
Moore, D.3
-
62
-
-
0003636657
-
-
Office of Technology Assessment. OTA-H-522 February Accessed 6 May 2012
-
Office of Technology Assessment. Pharmaceutical R&D: costs, risks and rewards, OTA-H-522 (February 1993). www.fas.org/ota/reports/9336.pdf (Accessed 6 May 2012)
-
(1993)
Pharmaceutical R&D: Costs, Risks and Rewards
-
-
|