Targeted endothelial gene delivery by ultrasonic destruction of magnetic microbubbles carrying lentiviral vectors

Pharmaceutical Research

Volumn 29, Issue 5, 2012, Pages 1282-1294

  Mannell, Hanna ^a   Pircher, Joachim ^a   Räthel, Thomas ^a   Schilberg, Katharina ^a   Zimmermann, Katrin ^b   Pfeifer, Alexander ^b   Mykhaylyk, Olga ^c   Gleich, Bernhard ^c   Pohl, Ulrich ^a   Krötz, Florian ^a  

^a LUDWIG MAXIMILIANS UNIVERSITY   (Germany)

^b UNIVERSITY OF BONN   (Germany)

^c TECHNICAL UNIVERSITY OF MUNICH   (Germany)

Author keywords

Endothelial cells; Gene delivery; Lentiviral transduction; Magnetic nanoparticles; Microbubbles; Ultrasound

Indexed keywords

3 (4,5 DIMETHYL 2 THIAZOLYL) 2,5 DIPHENYLTETRAZOLIUM BROMIDE; ENHANCED GREEN FLUORESCENT PROTEIN; LENTIVIRUS VECTOR; MAGNETIC NANOPARTICLE; SUPERPARAMAGNETIC IRON OXIDE NANOPARTICLE;

ARTICLE; CELL VIABILITY; CONTROLLED STUDY; ECHOGRAPHY; ENDOTHELIUM CELL; FLOW CYTOMETRY; FLUORESCENCE MICROSCOPY; GENETIC TRANSFECTION; HUMAN; HUMAN CELL; IN VITRO STUDY; MAGNETIC FIELD; MICROBUBBLE; NONHUMAN; PARTICLE SIZE; PRECIPITATION; PRIORITY JOURNAL; PROCESS DEVELOPMENT; SIGNAL TRANSDUCTION; SYSTEMIC THERAPY; TARGET CELL DESTRUCTION; VIRAL GENE DELIVERY SYSTEM; VIRUS CELL INTERACTION; X RAY PHOTOELECTRON SPECTROSCOPY;

CELL SURVIVAL; DRUG DELIVERY SYSTEMS; ENDOTHELIAL CELLS; FLOW CYTOMETRY; GENE TRANSFER TECHNIQUES; GENETIC VECTORS; GREEN FLUORESCENT PROTEINS; HUMANS; LENTIVIRUS; MAGNETICS; MICROBUBBLES; PARTICLE SIZE; ULTRASONICS;

EID: 84862686673     PISSN: 07248741     EISSN: 1573904X     Source Type: Journal    
DOI: 10.1007/s11095-012-0678-8     Document Type: Article

References (31)

1. Barry MA, Hofherr SE, Chen CY, Senac JS, Hillestad ML, Shashkova EV. Systemic delivery of therapeutic viruses. Curr Opin Mol Ther. 2009;11:411-20.
2. Pfeiferand A, Hofmann A. Lentiviral transgenesis. Methods Mol Biol. 2009;530:391-405.
3. Cines DB, Pollak ES, Buck CA, Loscalzo J, Zimmerman GA, McEver RP, Pober JS, Wick TM, Konkle BA, Schwartz BS, Barnathan ES, McCrae KR, Hug BA, Schmidt AM, Stern DM. Endothelial cells in physiology and in the pathophysiology of vascular disorders. Blood. 1998;91:3527-61.
4. Phillips L, Klibanov A, Wamhoff B, Hossack J. Targeted gene transfection from microbubbles into vascular smooth muscle cells using focused, ultrasound-mediated delivery. Ultrasound Med Biol. 2010;36:1470-80.
5. Zhou J, Wang Y, Xiong Y, Wang H, Feng Y, Chen J. Delivery of TFPI-2 using ultrasound with a microbubble agent (SonoVue) inhibits intimal hyperplasia after balloon injury in a rabbit carotid artery model. Ultrasound Med Biol. 2010;36:1876-83.
6. Tinkov S, Coester C, Serba S, Geis N, Katus H, Winter G, Bekeredjian R. New doxorubicin-loaded phospholipid microbubbles for targeted tumor therapy: in-vivo characterization. J Control Release. 2010;148:368-72.
7. Kondo I, Ohmori K, Oshita A, Takeuchi H, Fuke S, Shinomiya K, Noma T, Namba T, Kohno M. Treatment of acute myocardial infarction by hepatocyte growth factor gene transfer: the first demonstration of myocardial transfer of a "functional" gene using ultrasonic microbubble destruction. J Am Coll Cardiol. 2004;44:644-53.
8. Bekeredjian R, Chen S, Frenkel PA, Grayburn PA, Shohet RV. Ultrasound-targeted microbubble destruction can repeatedly direct highly specific plasmid expression to the heart. Circulation. 2003;108:1022-6.
9. Stride E, Porter C, Prieto AG, Pankhurst Q. Enhancement of micro-bubble mediated gene delivery by simultaneous exposure to ultrasonic and magnetic fields. Ultrasound Med Biol. 2009;35:861-8.
10. Vlaskou D, Pradhan P, Bergemann C, Klibanov AL, Hensel K, Schmitz G, Plank C, Mykhaylyk O. Magnetic microbubbles: magnetically targeted and ultrasound-triggered vectors for gene delivery in vitro. AIP Conf Proc. 2010;1311:485-94.
11. Liu Y, Miyoshi H, Nakamura M. Encapsulated ultrasound micro-bubbles: therapeutic application in drug/gene delivery. J Control Release. 2006;114:89-99.
12. Lampe M, Briggs J, Endress T, Glass B, Riegelsberger S, Krausslich H, Lamb D, Brauchle C, Muller B. Double-labelled HIV-1 particles for study of virus-cell interaction. Virology. 2007;360:92-104.
13. Hofmann A, Wenzel D, Becher UM, Freitag DF, Klein AM, Eberbeck D, Schulte M, Zimmermann K, Bergemann C, Gleich B, Roell W, Weyh T, Trahms L, Nickenig G, Fleischmann BK, Pfeifer A. Combined targeting of lentiviral vectors and positioning of transduced cells by magnetic nanoparticles. Proc Natl Acad Sci USA. 2009;106:44-9.
14. Trueck C, Zimmermann K, Mykhaylyk O, Anton M, Vosen S, Wenzel D, Fleischmann B, Pfeifer A. Optimization of magnetic nanoparticles assisted lentiviral gene transfer. Pharmaceut Res. In revision; 2011.
15. Mannell H, Hellwig N, Gloe T, Plank C, Sohn HY, Groesser L, Walzog B, Pohl U, Krotz F. Inhibition of the tyrosine phosphatase SHP-2 suppresses angiogenesis in vitro and in vivo. J Vasc Res. 2008;45:153-63.
16. Mykhaylyk O, Antequera Y, Vlaskou D, Plank C. Generation of magnetic nonviral gene transfer agents and magnetofection in vitro. Nat Protoc. 2007;2:2391-411.
17. Vlaskou D, Mykhaylyk O, Tresilwised N, Pithayanukul P, Möller W, Plank C. Magnetic nanoparticle formulations for DNA and siRNA delivery. J Magn Magn Mater. 2007;311:275-81.
18. Mykhaylyk O, Sanchez-Antequera Y, Vlaskou D, Hammerschmid E, Anton M, Zelphati O, Plank C. Liposomal magnetofection. Meth Mol Biol. 2010;605:487-525.
19. Mykhaylyk O, Zelphati O, Hammerschmid E, Anton M, Rosenecker J, Plank C. Recent advances in magnetofection and its potential to deliver siRNAs in vitro. Methods Mol Biol. 2009;487:111-46.
20. Räthel T, Mannell H, Gleich B, Pohl U, Krötz F. Magnetic stents retain nanoparticle-bound antirestenotic drugs transported by lipid microbubbles Pharmaceutical Research. Accepted, 2011.
21. Krotz F, de Wit C, Sohn HY, Zahler S, Gloe T, Pohl U, Plank C. Magnetofection-a highly efficient tool for antisense oligonucleotide delivery in vitro and in vivo. Mol Ther. 2003;7:700-10.
22. Krotz F, Sohn HY, Gloe T, Plank C, Pohl U. Magnetofection potentiates gene delivery to cultured endothelial cells. J Vasc Res. 2003;40:425-34.
23. Soetanto K. Development of magnetic microbubbles for Drug Delivery System (DDS). Jpn J Appl Phys. 2000;39:3230-2.
24. Shohet RV, Chen S, Zhou Y-T, Wang Z, Meidell RS, Unger RH, Grayburn PA. Echocardiographic destruction of albumin micro-bubbles directs gene delivery to the myocardium. Circulation. 2000;101:2554-6.
25. Beeri R, Guerrero JL, Supple G, Sullivan S, Levine RA, Hajjar RJ. New efficient catheter-based system for myocardial gene delivery. Circulation. 2002;106:1756-9.
26. Taylor S, Rahim A, Bush N, Bamber J, Porter C. Targeted retroviral gene delivery using ultrasound. J Gene Med. 2007;9:77-87.
27. Su C, Chang C, Wang H, Wu Y, Bettinger T, Tsai C, Yeh H. Ultrasonic microbubble-mediated gene delivery causes phenotypic changes of human aortic endothelial cells. Ultrasound Med Biol. 2010;36:449-58.
28. Wang Y, Xu H, Lu M, Tang Q. Expression of thymidine kinase mediated by a novel non-viral delivery system under the control of vascular endothelial growth factor receptor 2 promoter selectively kills human umbilical vein endothelial cells. World J Gastroenterol. 2008;14:224-30.
29. Meijering B, Henning R, Van Gilst W, Gavrilovic I, Van Wamel A, Deelman L. Optimization of ultrasound and microbubbles targeted gene delivery to cultured primary endothelial cells. J Drug Target. 2007;15:664-71.
30. Pislaru SV, Harbuzariu A, Gulati R, Witt T, Sandhu NP, Simari RD, Sandhu GS. Magnetically targeted endothelial cell localization in stented vessels. J Am Coll Cardiol. 2006;48:1839-45.
31. Chorny M, Fishbein I, Yellen BB, Alferiev IS, Bakay M, Ganta S, Adamo R, Amiji M, Friedman G, Levy RJ. Targeting stents with local delivery of paclitaxel-loaded magnetic nanoparticles using uniform fields. Proc Natl Acad Sci USA. 2010;107:8346-51.