Hippocampal dosimetry predicts neurocognitive function impairment after fractionated stereotactic radiotherapy for benign or low-grade adult brain tumors

International Journal of Radiation Oncology Biology Physics

Volumn 83, Issue 4, 2012, Pages

  Gondi, Vinai ^a   Hermann, Bruce P ^a   Mehta, Minesh P ^c   Tomé, Wolfgang A ^a,b  

^a UNIVERSITY OF WISCONSIN SCHOOL OF MEDICINE AND PUBLIC HEALTH   (United States)

^b University of Wisconsin Madison   (United States)

^c NORTHWESTERN UNIVERSITY   (United States)

Author keywords

Brain tumors; Conformal radiotherapy; Hippocampus; Neurocognitive function; Radiation Therapy Oncology Group 0933

Indexed keywords

ADULT BRAIN; ADULT PATIENTS; BINARY LOGISTIC REGRESSION; BRAIN TUMORS; CLINICAL TRIAL; CONFORMAL RADIOTHERAPY; CRANIAL IRRADIATION; DOSE RESPONSE; DOSE-VOLUME HISTOGRAMS; EQUIVALENT DOSE; EXACT TESTS; FRACTIONATED STEREOTACTIC RADIOTHERAPY; HEALTHY CONTROLS; HIPPOCAMPUS; INTENSITY-MODULATED RADIOTHERAPY; MULTI VARIATE ANALYSIS; NON-LINEAR MODEL; ODDS RATIOS; RADIATION THERAPY ONCOLOGY GROUPS; UNIVARIATE; WORD LISTS; Z-SCORES;

DOSIMETRY; LOGISTICS; ONCOLOGY; RADIOTHERAPY; TUMORS;

BRAIN;

ADULT; AGED; ARTICLE; BRAIN TUMOR; CANCER GRADING; CANCER RADIOTHERAPY; CLINICAL ARTICLE; CLINICAL TRIAL; COGNITION; COGNITIVE DEFECT; CONTROLLED STUDY; FEMALE; FOLLOW UP; FRACTIONATED STEREOTACTIC RADIOTHERAPY; HIPPOCAMPUS; HISTOGRAM; HUMAN; MALE; PRIORITY JOURNAL; RADIATION DOSE;

ADULT; AGED; AGED, 80 AND OVER; BRAIN NEOPLASMS; CASE-CONTROL STUDIES; DOSE FRACTIONATION; DOSE-RESPONSE RELATIONSHIP, RADIATION; FEMALE; GLIOMA; HIPPOCAMPUS; HUMANS; MALE; MEMORY DISORDERS; MENINGEAL NEOPLASMS; MENINGIOMA; MENTAL RECALL; MIDDLE AGED; NEURILEMMOMA; ORGAN SPARING TREATMENTS; PROSPECTIVE STUDIES; RADIOSURGERY; REGRESSION ANALYSIS; YOUNG ADULT;

EID: 84862684991     PISSN: 03603016     EISSN: 1879355X     Source Type: Journal    
DOI: 10.1016/j.ijrobp.2011.10.021     Document Type: Article

References (18)

1. Gondi V, Tomé WA, Mehta MP. Why avoid the hippocampus? A comprehensive review. Radiother Oncol 2010;97:370-376.
2. Raber J, Rola R, LeFevour A, et al. Radiation-induced cognitive impairments are associated with changes in indicators of hippocampal neurogenesis. Radiat Res 2004;162:39-47.
3. Madsen TM, Kristjansen PE, Bolwig TG, et al. Arrested neuronal proliferation and impaired hippocampal function following fractionated brain irradiation in the adult rat. Neuroscience 2003;119:635-642.
4. Tomé WA, Meeks SL, McNutt TR, et al. Optically guided intensity modulated radiotherapy. Radiother Oncol 2001;61:33-44.
5. Tomé WA, Meeks SL, Buatti JM, et al. A high-precision system for conformal intracranial radiotherapy. Int J Radiat Oncol Biol Phys 2000;47:1137-1143.
6. Gondi V, Tolakanahalli R, Mehta MP, et al. Hippocampal-sparing whole-brain radiotherapy: A "how-to" technique using helical tomotherapy and linear acceleratorebased intensity modulated radiotherapy. Int J Radiat Oncol Biol Phys 2010;78:1244-1252.
7. Hermann BP, Seidenberg M, Schoenfeld J, et al. Empirical techniques for determining the reliability, magnitude, and pattern of neuropsychological change after epilepsy surgery. Epilepsia 1996;37:942-950.
8. Cameron HA, Woolley CS, McEwen BS, et al. Differentiation of newly born neurons and glia in the dentate gyrus of the adult rat. Neuroscience 1993;56:337-344.
9. Eriksson PS, Perfilieva E, Bjork-Eriksson T, et al. Neurogenesis in the adult human hippocampus. Nat Med 1998;4:1313-1317.
10. Lemaire V, Koehl M, Le Moal M, et al. Prenatal stress produces learning deficits associated with an inhibition of neurogenesis in the hippocampus. Proc Natl Acad Sci U S A 2000;97:11032-11037.
11. Monje ML, Mizumatsu S, Fike JR, et al. Irradiation induces neural precursor-cell dysfunction. Nat Med 2002;8:955-962.
12. Hsiao KY, Yeh SA, Chang CC, et al. Cognitive function before and after intensity-modulated radiation therapy in patients with nasopharyngeal carcinoma: A prospective study. Int J Radiat Oncol Biol Phys 2010;77:722-726.
13. Jalali R, Mallick I, Dutta D, et al. Factors influencing neurocognitive outcomes in young patients with benign and low-grade brain tumors treated with stereotactic conformal radiotherapy. Int J Radiat Oncol Biol Phys 2010;77:974-979.
14. Chang EL, Wefel JS, Hess KR, et al. Neurocognition in patients with brain metastases treated with radiosurgery or radiosurgery plus whole-brain irradiation: A randomised controlled trial. Lancet Oncol 2009;10:1037-1044.
15. Sun A, Bae K, Gore EM, et al. Phase III trial of prophylactic cranial irradiation compared with observation in patients with locally advanced non-small-cell lung cancer: Neurocognitive and quality-of-life analysis. J Clin Oncol 2010;29:279-286.
16. Douw L, Klein M, Fagel SS, et al. Cognitive and radiological effects of radiotherapy in patients with low-grade glioma: Long-term follow-up. Lancet Neurol 2009;8:810-818.
17. Shrager Y, Levy DA, Hopkins RO, et al. Working memory and the organization of brain systems. J Neurosci 2008;28:4818-4822.
18. Muller NG, Knight RT. The functional neuroanatomy of working memory: Contributions of human brain lesion studies. Neuroscience 2006;139:51-58.