Enhanced gene delivery to human primary endothelial cells using tropism-modified adenovirus vectors

Open Gene Therapy Journal

Volumn 1, Issue , 2008, Pages 7-11

  Preuss, Meredith A ^a   Glasgow, Joel N ^a,b,c   Everts, Maaike ^a,b,d   Stoff Khalili, Mariam A ^a   Wu, Hongju ^a,b   Curiel, David T ^a,b  

^a University of Alabama at Birmingham   (United States)

^b UNIVERSITY OF ALABAMA SCHOOL OF MEDICINE   (United States)

^c University of Alabama at Birmingham and Birmingham Veterans Affairs Medical Center   (United States)

^d University of Alabama at Birmingham   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

EID: 84862680994     PISSN: None     EISSN: 18750370     Source Type: Journal    
DOI: 10.2174/1875037000801010007     Document Type: Article

References (28)

1. Aird WC. Endothelial cell heterogeneity. Crit Care Med 2003; 31(4 Suppl): S221-30.
2. Mathis JM, Stewart PL, Zhu ZB, Curiel DT. Advanced generation adenoviral virotherapy agents embody enhanced potency based upon CAR-independent tropism. Clin Cancer Res 2006; 12(9): 2651-6.
3. Henry LJ, Xia D, Wilke ME, Deisenhofer J, Gerard RD. Characterization of the knob domain of the adenovirus type 5 fiber protein expressed in Escherichia coli. J Virol 1994; 68(8): 5239-46.
4. Xia D, Henry LJ, Gerard RD, Deisenhofer J. Crystal structure of the receptor-binding domain of adenovirus type 5 fiber protein at 1.7 A resolution. Structure 1994; 2(12): 1259-70.
5. Tomko RP, Xu R, Philipson L. HCAR and MCAR: the human and mouse cellular receptors for subgroup C adenoviruses and group B coxsackieviruses. Proc Natl Acad Sci USA 1997; 94(7): 3352-6.
6. Bergelson JM, Cunningham JA, Droguett G, et al. Isolation of a common receptor for Coxsackie B viruses and adenoviruses 2 and 5. Science 1997; 275(5304): 1320-3.
7. Louis N, Fender P, Barge A, Kitts P, Chroboczek J. Cell-binding domain of adenovirus serotype 2 fiber. J Virol 1994; 68(6): 4104-6.
8. Davison E, Diaz RM, Hart IR, Santis G, Marshall JF. Integrin alpha5beta1-mediated adenovirus infection is enhanced by the integrin-activating antibody TS2/16. J Virol 1997; 71(8): 6204-7.
9. Li E, Brown SL, Stupack DG, Puente XS, Cheresh DA, Nemerow GR. Integrin alpha(v)beta1 is an adenovirus coreceptor. J Virol 2001; 75(11): 5405-9.
10. Wickham TJ, Mathias P, Cheresh DA, Nemerow GR. Integrins alpha v beta 3 and alpha v beta 5 promote adenovirus internalization but not virus attachment. Cell 1993; 73(2): 309-19.
11. Salone B, Martina Y, Piersanti S, et al. Integrin alpha3beta1 is an alternative cellular receptor for adenovirus serotype 5. J Virol 2003; 77(24): 13448-54.
12. Bai M, Harfe B, Freimuth P. Mutations that alter an Arg-Gly-Asp (RGD) sequence in the adenovirus type 2 penton base protein abolish its cell-rounding activity and delay virus reproduction in flat cells. J Virol 1993; 67(9): 5198-205.
13. Glasgow JN, Everts M, Curiel DT. Transductional targeting of adenovirus vectors for gene therapy. Cancer Gene Ther 2006; 13(9): 830-44.
14. Carson SD, Hobbs JT, Tracy SM, Chapman NM. Expression of the coxsackievirus and adenovirus receptor in cultured human umbilical vein endothelial cells: regulation in response to cell density. J Virol 1999; 73(8): 7077-9.
15. Raschperger E, Thyberg J, Pettersson S, Philipson L, Fuxe J, Pettersson RF. The coxsackie-and adenovirus receptor (CAR) is an in vivo marker for epithelial tight junctions, with a potential role in regulating permeability and tissue homeostasis. Exp Cell Res 2006; 312(9): 1566-80.
16. Dmitriev I, Krasnykh V, Miller CR, et al. An adenovirus vector with genetically modified fibers demonstrates expanded tropism via utilization of a coxsackievirus and adenovirus receptorindependent cell entry mechanism. J Virol 1998; 72(12): 9706-13.
17. Wu H, Seki T, Dmitriev I, et al. Double modification of adenovirus fiber with RGD and polylysine motifs improves coxsackievirusadenovirus receptor-independent gene transfer efficiency. Hum Gene Ther 2002; 13(13): 1647-53.
18. Krasnykh VN, Mikheeva GV, Douglas JT, Curiel DT. Generation of recombinant adenovirus vectors with modified fibers for altering viral tropism. J Virol 1996; 70(10): 6839-46.
19. Stoff-Khalili MA, Rivera AA, Glasgow JN, et al. A human adenoviral vector with a chimeric fiber from canine adenovirus type 1 results in novel expanded tropism for cancer gene therapy. Gene Ther 2005; 12(23): 1696-706.
20. Glasgow JN, Kremer EJ, Hemminki A, Siegal GP, Douglas JT, Curiel DT. An adenovirus vector with a chimeric fiber derived from canine adenovirus type 2 displays novel tropism. Virology 2004; 324(1): 103-16.
21. Nicklin SA, White SJ, Nicol CG, Von Seggern DJ, Baker AH. In vitro and in vivo characterisation of endothelial cell selective adenoviral vectors. J Gene Med 2004; 6(3): 300-8.
22. Stevenson SC, Rollence M, Marshall-Neff J, McClelland A. Selective targeting of human cells by a chimeric adenovirus vector containing a modified fiber protein. J Virol 1997; 71(6): 4782-90.
23. Jornot L, Morris MA, Moix I, Rochat T. N-acetylcyteine augments adenovirus-mediated gene expression in human endothelial cells by enhancing transgene transcription and virus entry. J Gene Med 2002; 4: 54-65.
24. Denby L, Work LM, Graham D, et al. Adenoviral serotype 5 vectors pseudotyped with fibers from subgroup D show modified tropism in vitro and in vivo. Hum Gene Ther 2004; 15(11): 1054-64.
25. Shinozaki K, Suominen E, Carrick F, et al. Efficient infection of tumor endothelial cells by a capsid-modified adenovirus. Gene Ther 2006; 13(1): 52-9.
26. Fleischli C, Sirena D, Lesage G, et al. Species B adenovirus serotypes 3, 7, 11, and 35 share similar binding sites on the membrane cofactor protein CD46 receptor. J Gen Virol 2007; 88(pt11): 2925-34.
27. Marttila M, Persson D, Gustafsson D, et al. CD46 is a cellular receptor for all species B adenoviruses except types 3 and 7. J Virol 2005; 79(22): 14429-36.
28. Kremer EJ. CAR chasing: canine adenovirus vectors-all bite and no bark? J Gene Med 2004; 6 (Suppl 1): S139-51.