The interaction between hepatitis B virus X protein and AIB1 oncogene is required for the activation of NFκB signal transduction

Biochemical and Biophysical Research Communications

Volumn 423, Issue 1, 2012, Pages 6-12

  Hong, Andy ^a   Han, Dong Dong ^d   Wright, Christine J ^a   Burch, Tanya ^a   Piper, Jessica ^a   Osiowy, Carla ^a,b   Gao, Chunjin ^d   Chiang, Shirley ^a   Magill, Travis ^a   Dick, Kevin ^a   Booth, Timothy F ^a,b   Li, Xuguang ^c   He, Runtao ^a,b  

^a PUBLIC HEALTH AGENCY OF CANADA   (Canada)

^b UNIVERSITY OF MANITOBA   (Canada)

^c HEALTH CANADA   (Canada)

^d CAPITAL MEDICAL UNIVERSITY   (China)

Author keywords

AIB1; Hepatitis B; Hepatocellular carcinoma; Interaction; NCoA 3; NFkB; SRC 3; X protein

Indexed keywords

AMINO ACID; HEPATITIS B VIRUS X PROTEIN; IMMUNOGLOBULIN ENHANCER BINDING PROTEIN;

AMINO ACID SEQUENCE; ARTICLE; CONTROLLED STUDY; HUMAN; HUMAN CELL; HUMAN TISSUE; LIVER CELL CARCINOMA; MUTANT; NUCLEOTIDE SEQUENCE; ONCOGENE; PRIORITY JOURNAL; PROTEIN INTERACTION; PROTEIN MOTIF; PROTEIN PROTEIN INTERACTION; SIGNAL TRANSDUCTION;

AMINO ACID SEQUENCE; CARCINOGENS; CARCINOMA, HEPATOCELLULAR; CELL LINE, TUMOR; CONSERVED SEQUENCE; HUMANS; MOLECULAR SEQUENCE DATA; MUTATION; NF-KAPPA B; NUCLEAR RECEPTOR COACTIVATOR 3; PROTEIN INTERACTION DOMAINS AND MOTIFS; SERINE; SIGNAL TRANSDUCTION; TRANS-ACTIVATORS; TWO-HYBRID SYSTEM TECHNIQUES;

HEPATITIS B VIRUS;

EID: 84862677962     PISSN: 0006291X     EISSN: 10902104     Source Type: Journal    
DOI: 10.1016/j.bbrc.2012.05.021     Document Type: Article

References (25)

1. Tan Y.J. Hepatitis B virus infection and the risk of hepatocellular carcinoma. World J. Gastroenterol. 2011, 17(44):4853-4857.
2. Wei Y., Neuveut C., Tiollais P., Buendia M.A. Molecular biology of the hepatitis B virus and role of the X gene. Pathol. Biol. 2010, 58(4):267-272.
3. Ng S.A., Lee C. Hepatitis B virus X gene and hepatocarcinogenesis. J. Gastroenterol. 2011, 46(8):974-990.
4. York B., O'Malley B.W. Steroid receptor coactivator (SRC) family: masters of systems biology. J. Biol. Chem. 2010, 285(50):38743-38750.
5. Xu J., Li Q. Review of the in vivo functions of the p160 steroid receptor coactivator family. Mol. Endocrinol. 2003, 17(9):1681-1692.
6. Lydon J.P., O'Malley B.W. Minireview: steroid receptor coactivator-3: a multifarious coregulator in mammary gland metastasis. Endocrinology 2011, 152(1):19-25.
7. Gojis O., Rudraraju B., Alifrangis C., Krell J., Libalova P., Palmieri C. The role of steroid receptor coactivator-3 (SRC-3) in human malignant disease. Eur. J. Surg. Oncol. 2010, 36(3):224-229.
8. He R., Li X. Mammalian two-hybrid assay for detecting protein-protein interactions in vivo. Methods Mol. Biol. 2008, 439:327-337.
9. Cheng A.S., Chan H.L., Leung W.K., To K.F., Go M.Y., Chan J.Y., Liew C.T., Sung J.J. Expression of HBx and COX-2 in chronic hepatitis B, cirrhosis and hepatocellular carcinoma: implication of HBx in upregulation of COX-2. Mod. Pathol. 2004, 17(10):1169-1179.
10. Carroll R.S., Brown M., Zhang J., DiRenzo J., Font De Mora J., Black P.M. Expression of a subset of steroid receptor cofactors is associated with progesterone receptor expression in meningiomas. Clin. Cancer Res. 2000, 6(9):3570-3575.
11. Savkur R.S., Burris T.P. The coactivator LXXLL nuclear receptor recognition motif. J. Pept. Res. 2004, 63(3):207-212.
12. Kew M.C. Hepatitis B virus x protein in the pathogenesis of hepatitis B virus-induced hepatocellular carcinoma. J. Gastroenterol. Hepatol. 2011, (1):144-152.
13. Hwang Y.K., Kim N.K., Park J.M., Lee K., Han W.K., Kim H.I., Cheong H.S. HLA-A2 1 restricted peptides from the HBx antigen induce specific CTL responses in vitro and in vivo. Vaccine 2002, 20:3770-3777.
14. Paterlini P., Poussin K., Kew M., Franco D., Bréchot C. Selective accumulation of the X transcript of hepatitis B virus in patients negative for hepatitis B surface antigen with hepatocellular carcinoma. Hepatology 1995, 21:313-321.
15. Peng Z., Zhang Y., Gu W., Wang Z., Li D., Zhang F., Qiu G., Xie K. Integration of the hepatitis B virus X fragment in hepatocellular carcinoma and its effects on the expression of multiple molecules: a key to the cell cycle and apoptosis. Int. J. Oncol. 2005, 26:467-473.
16. Su Q., Schrô der C.H., Hofman W.J., Otto G., Pichlmayr R., Bannasch P. Expression of hepatitis B virus X protein in HBV-infected human livers and hepatocellular carcinoma. Hepatology 1998, 27:1109-1120.
17. Pang R., Lee T.K., Poon R.T., Fan S.T., Wong K.B., Kwong Y.L., Tse E. Pin1 interacts with a specific serine-proline motif of hepatitis B virus X-protein to enhance hepatocarcinogenesis. Gastroenterology 2007, 132(3):1088-1103.
18. Liao L., Kuang S.Q., Yuan Y., Gonzalez S.M., O'Malley B.W., Xu J. Molecular structure and biological function of the cancer-amplified nuclear receptor coactivator SRC-3/AIB1. J. Steroid Biochem. Mol. Biol. 2002, 83(1-5):3-14.
19. Chiang S., Burch T., Van Domselaar G., Dick K., Radziwon A., Brusnyk C., Edwards M.R., Piper J., Cutts T., Cao J., Li X., He R. The interaction between thymine DNA glycosylase and nuclear receptor coactivator 3 is required for the transcriptional activation of nuclear hormone receptors. Mol. Cell Biochem. 2010, 333(1-2):221-232.
20. Chen F., Beezhold K., Castranova V. Tumor promoting or tumor suppressing of NF-kappa B, a matter of cell context dependency. Int. Rev. Immunol. 2008, 27(4):183-204.
21. Celec P. Nuclear factor kappa B - molecular biomedicine: the next generation. Biomed. Pharmacother. 2002, 58(6-7):365-371.
22. Liou H.C., Baltimore D. Regulation of the NF-kappa B/rel transcription factor and I kappa B inhibitor system. Curr. Opin. Cell Biol. 1993, 5(3):477-487.
23. Na S.Y., Lee S.K., Han S.J., Choi H.S., Im S.Y., Lee J.W. Steroid receptor coactivator-1 interacts with the p50 subunit and coactivates nuclear factor kappa B-mediated transactivations. J. Biol. Chem. 1998, 273(18):10831-10834.
24. Purcell N.H., Yu C., He D., Xiang J., Paran N., DiDonato J.A., Yamaoka S., Shaul Y., Lin A. Activation of NF-kappa B by hepatitis B virus X protein through an I kappa B kinase-independent mechanism. Am. J. Physiol. Gastrointest. Liver Physiol. 2001, 280(4):G669-G677.
25. Lucito R., Schneider R.J. Hepatitis B virus X protein activates transcription factor NF-kappa B without a requirement for protein kinase C. J. Virol. 1992, 66(2):983-991.