Iron overload potentiates diet-induced hypercholesterolemia and reduces liver ppar-α expression in hamsters

Journal of Biochemical and Molecular Toxicology

Volumn 26, Issue 6, 2012, Pages 224-229

  Bonomo, Larissa de Freitas ^a   Silva, Maísa ^a   Oliveira, Riva de Paula ^a   Silva, Marcelo Eustáquio ^a   Pedrosa, Maria Lucia ^a  

^a FEDERAL UNIVERSITY OF OURO PRETO   (Brazil)

Author keywords

7 hydroxilase; Cholesterol; HMG CoA redutase; Iron overload; PPAR

Indexed keywords

ARYLDIALKYLPHOSPHATASE 1; CHOLESTEROL; CHOLESTEROL 7ALPHA MONOOXYGENASE; HIGH DENSITY LIPOPROTEIN CHOLESTEROL; HYDROXYMETHYLGLUTARYL COENZYME A REDUCTASE; IRON; IRON DEXTRAN; PEROXISOME PROLIFERATOR ACTIVATED RECEPTOR ALPHA; TRIACYLGLYCEROL;

ANIMAL EXPERIMENT; ANIMAL MODEL; ANIMAL TISSUE; ARTICLE; CHOLESTEROL BLOOD LEVEL; CHOLESTEROL DIET; CONTROLLED STUDY; ENZYME ACTIVITY; GENE EXPRESSION; HAMSTER; HOMEOSTASIS; HYPERCHOLESTEROLEMIA; IRON OVERLOAD; LIVER WEIGHT; MALE; NONHUMAN; PROTEIN EXPRESSION; WEIGHT GAIN;

ANIMALS; CRICETINAE; DIET; GENE EXPRESSION; HYPERCHOLESTEROLEMIA; IRON OVERLOAD; LIVER; MALE; MESOCRICETUS; PPAR ALPHA;

CRICETINAE;

EID: 84862677186     PISSN: 10956670     EISSN: 10990461     Source Type: Journal    
DOI: 10.1002/jbt.21410     Document Type: Article

References (25)

1. Sheth S, Brittenham GM. Genetic disorders affecting proteins of iron metabolism: Clinical implications. Annu Rev Med 2000;51:443-464.
2. Luan de C, Li H, Li SJ, Zhao Z, Li X, Liu ZM. Body iron stores and dietary iron intake in relation to diabetes in adults in North China. Diabetes Care 2008;31(2):285-286.
3. Sullivan JL. Iron and the sex difference in heart disease risk. Lancet 1981;1(8233):1293-1294.
4. Stanley N, Stadler N, Woods AA, Bannon PG, Davies MJ. Concentrations of iron correlate with the extent of protein, but not lipid, oxidation in advanced human atherosclerotic lesions. Free Radic Biol Med 2006;40(9):1636-1643.
5. Emara AM, El Kelany RS, Moustafa KA. Comparative study of the protective effect between deferoxamine and deferiprone on chronic iron overload induced cardiotoxicity in rats. Hum Exp Toxicol 2006;25(7):375-385.
6. Després JP. Is visceral obesity the cause of the metabolic syndrome? Ann Med 2006;38(1):52-63.
7. Nesto RW. Managing cardiovascular risk in patients with metabolic syndrome. Clin Cornerstone 2005;7(2-3):46-51.
8. Barisani D, Pelucchi S, Mariani R, Galimberti S, Trombini P, Fumagalli D, Meneveri R, Nemeth E, Ganz T, Piperno A. Hepcidin and iron-related gene expression in subjects with dysmetabolic hepatic iron overload. J Hepatol 2008;49(1):123-133.
9. Menke A, Fernández-Real JM, Muntner P, Guallar E. The association of biomarkers of iron status with peripheral arterial disease in US adults. BMC Cardiovasc Disord 2009;9:34.
10. Kraml PJ, Klein RL, Huang Y, Nareika A, Lopes-Virella MF. Iron loading increases cholesterol accumulation and macrophage scavenger receptor I expression in THP-1 mononuclear phagocytes. Metabolism 2005;54(4):453-459.
11. Tsuchiya H, Ashla AA, Hoshikawa Y, Matsumi Y, Kanki K, Enjoji M, Momosaki S, Nakamuta M, Taketomi A, Maehara Y, Shomori K, Kurimasa A, Hisatome I, Ito H, Shiota G. Iron state in association with retinoid metabolism in non-alcoholic fatty liver disease. Hepatol Res 2010;40(12):1227-1238.
12. Goldenberg I, Benderly M, Goldbourt U. Update on the use of fibrates: Focus on bezafibrate. Vasc Health Risk Manag 2008;4(1):131-141.
13. Devchand PR, Keller H, Peters JM, Vazquez M, Gonzalez FJ, Wahli W. The PPARalpha-leukotriene B4 pathway to inflammation control. Nature 1996;384(6604):39-43.
14. Feijó AGS, Braga LMGM, Pitrez PMC. Animais na pesquisa e no ensino: aspectos éticos e técnicos. Porto Alegre: EDIPUCRS, 2010, 421.
15. Turbino-Ribeiro SM, Silva ME, Chianca DA Jr, de Paula H, Cardoso LM, Colombari E, Pedrosa ML. Iron overload in hypercholesterolemic rats affects iron homeostasis and serum lipids but not blood pressure. J. Nutr 2003;133:15-20.
16. Association of Official Analytical Chemists. Official methods of analysis. Washington, DC: AOAC; 1980.
17. Palou M, Priego T, Sánchez J, Villegas E, Rodriguez AM, Palou A, Picó C. Sequential changes in the expression of genes involved in lipid metabolism in adipose tissue and liver in response to fasting. Pflugers Arch 2008;456:825-836.
18. Li G, Liu X, Zhu H, Huang L, Liu Y, Ma C, Qin C. Insulin resistance in insulin-resistant and diabetic hamsters (Mesocricetus auratus) is associated with abnormal hepatic expression of genes involved in lipid and glucose metabolism. Comp Med 2009;59(5):449-458.
19. Xiong Q, Xie P, Li H, Hao L, Li G, Qiu T, Liu Y. Acute effects of microcystins exposure on the transcription of antioxidant enzyme genes in three organs (liver, kidney, and testis) of male Wistar rats. J Biochem Mol Toxicol 2010;24:361-367.
20. Arocho A, Chen B, Ladanyi M, Pan Q. Validation of the 2-DeltaDeltaCt calculation as an alternate method of data analysis for quantitative PCR of BCR-ABL P210 transcripts. Diagn Mol Pathol 2006;15(1):56-61.
21. Marcil V, Delvin E, Sané AT, Tremblay A, Levy E. Oxidative stress influences cholesterol efflux in THP-1 macrophages: Role of ATP-binding cassette A1 and nuclear factors. Cardiovasc Res 2006;72(3):473-482.
22. Iemitsu M, Miyauchi T, Maeda S, Tanabe T, Takanashi M, Irukayama-Tomobe, Sakai S, Ohmori H, Matsuda M, Yamaguchi I. Aging-induced decrease in the PPAR-alpha level in hearts is improved by exercise training. Am J Physiol Heart Circ Physiol 2002;283(5):H1750-H1760.
23. Dabbagh AJ, Shwaery GT, Keaney JF, Frei B. Effect of iron overload and iron deficiency on atherosclerosis in hypercholesterolemic rabbit. Arterioscler Thromb Vasc Biol 1997;17:2638-2645.
24. Moghadasian MH. Experimental atherosclerosis: A historical overview. Life Sci 2002;70:855-865.
25. Remillard P, Shen G, Milne R, Maheux P. Induction of cholesteryl ester transfer protein in adipose tissue and plasma of the fructose-fed hamster. Life Sci 2001;69:677-687.