Fate and transport of atorvastatin and simvastatin drugs during conventional wastewater treatment

Chemosphere

Volumn 88, Issue 10, 2012, Pages 1184-1189

  Ottmar, Karl J ^a   Colosi, Lisa M ^a   Smith, James A ^a  

^a University of Virginia   (United States)

Author keywords

Biodegradation; Model; Pharmaceuticals; Sorption; Wastewater treatment

Indexed keywords

BIODEGRADATION; DRUG PRODUCTS; EFFLUENTS; METABOLITES; MODELS; SORPTION;

BIODEGRADATION EXPERIMENTS; CHOLESTEROL LOWERING; CONVENTIONAL TREATMENTS; EFFLUENT CONCENTRATIONS; ENVIRONMENTAL BEHAVIOR; ENVIRONMENTAL THREATS; INFLUENT CONCENTRATIONS; PHARMACEUTICAL DRUGS;

WASTEWATER TREATMENT;

ATORVASTATIN; SIMVASTATIN;

ACCURACY ASSESSMENT; BIODEGRADATION; DRUG; ECOTOXICOLOGY; EFFLUENT; ENVIRONMENTAL RISK; MASS BALANCE; METABOLITE; POLLUTANT REMOVAL; RESEARCH WORK; SORPTION; SUBSTRATE; WASTEWATER; WATER TREATMENT;

ACCURACY; ARTICLE; BIODEGRADATION; BIOMASS; EFFLUENT; ENVIRONMENTAL IMPACT; ENVIRONMENTAL PARAMETERS; VALIDATION PROCESS; WASTE WATER MANAGEMENT;

UNITED STATES;

EID: 84862666324     PISSN: 00456535     EISSN: 18791298     Source Type: Journal    
DOI: 10.1016/j.chemosphere.2012.03.066     Document Type: Article

References (17)

1. Brain R.A., Reitsma T.S., Lissemore L.I., Bestari K.J., Sibley P.K., Solomon K.R. Herbicidal effects of statin pharmaceuticals in Lemna gibba. Environ. Sci. Technol. 2006, 40:5116-5123.
2. Dahl U., Gorokhova E., Breitholtz M. Application of growth-related sublethal endpoints in ecotoxicological assessments using a harpacticoid copepod. Aquat. Toxicol. 2006, 77:433-438.
3. Daughton C.G. Chemicals from the practice of healthcare: challenges and unknowns posed by residues in the environment. Environ. Toxicol. Chem. 2009, 28:2490-2494.
4. Eaton A.D., Clesceri L.S., Greenberg A.E. Standard Methods for the Examination of Water and Wastewater 1995, American Public Health Association, Washington DC. 19th ed.
5. Ericson J.F. Evaluation of the OECD 314B activated sludge die-away test for assessing the biodegradation of pharmaceuticals. Environ. Sci. Technol. 2010, 44:375-381.
6. Gauthier H., Yargeau V., Cooper D.G. Biodegradation of pharmaceuticals by Rhodococcus rhodochrous and Aspergillus niger by co-metabolism. Sci. Total Environ. 2010, 408:1701-1706.
7. Glassmeyer S.T., Furlong E.T., Kolpin D.W., Cahill J.D., Zaugg S.D., Werner S.L., Meyer M.T., Kryak D.D. Transport of chemical and microbial compounds from known wastewater discharges: potential for use as indicators of human fecal contamination. Environ. Sci. Technol. 2005, 39:5157-5169.
8. Halden R.U., Paull D.H. Co-occurrence of triclobarban and triclosan in US water resources. Environ. Sci. Technol. 2005, 39:1420-1426.
9. IMSHealth. 2011. Top therapeutic classes by US dispensed prescriptions. [accessed 06.2011]. http://www.imshealth.com/deployedfiles/ims/Global/Content/Corporate/Press%20Room/Top-line%20Market%20Data/2010%20Top-line%20Market%20Data/2010_Top_Therapeutic_Classes_by_RX.pdf.
10. Jefferson B., Burgess J.E., Pichon A., Harkness J., Judd S.J. Nutrient addition to enhance biological treatment of greywater. Water Res. 2001, 35:2702-2710.
11. Karthikeyan K.G., Meyer M.T. Occurrence of antibiotics in wastewater treatment facilities in Wisconsin, USA. Sci. Total Environ. 2006, 361:196-207.
12. Ottmar K.J., Colosi L.M., Smith J.A. Development and application of a model to estimate wastewater treatment plant prescription pharmaceutical influent loadings and concentrations. B. Environ. Contam. Tox. 2010, 84:507-512.
13. Ottmar K.J., Colosi L.M., Smith J.A. Sorption of statin pharmaceuticals to wastewater-treatment biosolids, terrestrial soils, and freshwater sediment. J. Environ. Eng-ASCE. 2010, 136:256-264.
14. Pholchan P., Jones M., Donnelly T., Sallis P.J. Fate of estrogens during the biological treatment of synthetic wastewater in a nitrite-accumulating sequencing batch reactor. Environ. Sci. Technol. 2008, 42:6141-6147.
15. Tchobanoglous G., Burton F., Stensel D.H. Wastewater Engineering: Treatment and Reuse 2003, McGraw-Hill, New York. fourth ed.
16. Quintana J.B., Weiss S., Reemtsma T. Pathways and metabolites of microbial degradation of selected acidic pharmaceutical and their occurrence in municipal wastewater treated by a membrane bioreactor. Water Res. 2005, 39:2654-2664.
17. US Environmental Protection Agency. 2007. Method 1694: pharmaceuticals and personal care products in water, soil, sediment, and biosolids by HPLC/MS/MS.