A computational framework for the design of optimal protein synthesis

Biotechnology and Bioengineering

Volumn 109, Issue 8, 2012, Pages 2127-2133

  Racle, Julien ^a   Overney, Jan ^a   Hatzimanikatis, Vassily ^a  

^a EPFL   (Switzerland)

Author keywords

Computational biology; Optimization; Proteomics; Sensitivity analysis; Synthetic biology; Systems biology

Indexed keywords

CODON SEQUENCES; COMPUTATIONAL BIOLOGY; COMPUTATIONAL FRAMEWORK; DESIGN PRINCIPLES; EXPERIMENTAL STUDIES; HETEROLOGOUS EXPRESSION; HETEROLOGOUS PROTEIN PRODUCTION; MECHANISTIC MODELS; MULTIPLE CONSTRAINT; OPTIMAL STEADY STATE; PROTEIN SYNTHESIS; PROTEIN YIELD; PROTEOMICS; RATE LIMITING; SECONDARY STRUCTURES; SEQUENCE SPACE; STEADY STATE; SYNTHETIC BIOLOGY; SYSTEMS BIOLOGY;

BIOINFORMATICS; MOLECULAR BIOLOGY; PROTEINS; SENSITIVITY ANALYSIS;

OPTIMIZATION;

INTERLEUKIN 18; MESSENGER RNA; TRANSFER RNA;

ALGORITHM; ARTICLE; BIOTECHNOLOGY; CODON; CONCEPTUAL FRAMEWORK; CONTROLLED STUDY; GENE SEQUENCE; HETEROLOGOUS EXPRESSION; MATHEMATICAL MODEL; MUTANT; PROCESS DESIGN; PROCESS OPTIMIZATION; PROTEIN SECONDARY STRUCTURE; PROTEIN SYNTHESIS; RIBOSOME; RNA SEQUENCE; RNA TRANSLATION; STEADY STATE; SYNTHETIC BIOLOGY;

BIOTECHNOLOGY; CODON; COMPUTERS; MODELS, THEORETICAL; PROTEIN BIOSYNTHESIS; PROTEIN ENGINEERING; PROTEINS;

EID: 84862666301     PISSN: 00063592     EISSN: 10970290     Source Type: Journal    
DOI: 10.1002/bit.24463     Document Type: Article

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