Prostaglandin receptor EP4 in abdominal aortic aneurysms

American Journal of Pathology

Volumn 181, Issue 1, 2012, Pages 313-321

  Cao, Richard Y ^a   St Amand, Tim ^a   Li, XinZhi ^a   Yoon, Sung Hee ^a   Wang, Carol P ^a   Song, Hui ^a   Maruyama, Takayuki ^b   Brown, Peter M ^a   Zelt, David T ^a   Funk, Colin D ^a  

^a QUEEN S UNIVERSITY   (Canada)

^b ONO PHARMACEUTICAL CO   (Japan)

Author keywords

[No Author keywords available]

Indexed keywords

AE 3 208; CYCLOOXYGENASE 2; INTERLEUKIN 17; PROSTAGLANDIN E RECEPTOR 4; PROSTAGLANDIN RECEPTOR BLOCKING AGENT; UNCLASSIFIED DRUG;

ABDOMINAL AORTA ANEURYSM; ANIMAL EXPERIMENT; ANIMAL MODEL; ARTICLE; CELL EXPANSION; CONTROLLED STUDY; DISEASE SEVERITY; DRUG BLOOD LEVEL; INCIDENCE; MALE; MOUSE; NONHUMAN; PATHOGENESIS; PRIORITY JOURNAL; PROTEIN EXPRESSION; TH17 CELL;

ADULT; ANGIOTENSIN II; ANIMALS; AORTA; AORTIC ANEURYSM, ABDOMINAL; AORTIC RUPTURE; ATHEROSCLEROSIS; CYCLOOXYGENASE 2; DRUG EVALUATION, PRECLINICAL; FEMALE; GENE KNOCKDOWN TECHNIQUES; HUMANS; MACROPHAGES; MALE; MICE; MICE, KNOCKOUT; MIDDLE AGED; NAPHTHALENES; PHENYLBUTYRATES; RECEPTORS, PROSTAGLANDIN E, EP4 SUBTYPE; SIGNAL TRANSDUCTION;

EID: 84862665865     PISSN: 00029440     EISSN: 15252191     Source Type: Journal    
DOI: 10.1016/j.ajpath.2012.03.016     Document Type: Article

References (38)

1. Upchurch GR Jr, Schaub TA: Abdominal aortic aneurysm. Am Fam Physician 2006, 73:1198-1204
2. Lloyd-Jones D, Adams RJ, Brown TM, Carnethon M, Dai S, De Simone G, Ferguson TB, Ford E, Furie K, Gillespie C, Go A, Greenlund K, Haase N, Hailpern S, Ho PM, Howard V, Kissela B, Kittner S, Lackland D, Lisabeth L, Marelli A, McDermott MM, Meigs J, Mozaffarian D, Mussolino M, Nichol G, Roger VL, Rosamond W, Sacco R, Sorlie P, Thom T, Wasserthiel-Smoller S, Wong ND, Wylie-Rosett J: Heart disease and stroke statistics-2010 update: a report from the American Heart Association. Circulation 2010, 121:e46-e215
3. Golledge J, Muller J, Daugherty A, Norman P: Abdominal aortic aneurysm: pathogenesis and implications for management. Arterioscler Thromb Vasc Biol 2006, 26:2605-2613
4. van Vlijmen-van Keulen CJ, Pals G, Rauwerda JA: Familial abdominal aortic aneurysm: a systematic review of a genetic background. Eur J Vasc Endovasc Surg 2002, 24:105-116
5. McCormick ML, Gavrila D, Weintraub NL: Role of oxidative stress in the pathogenesis of abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 2007, 27:461-469
6. Thompson RW: Reflections on the pathogenesis of abdominal aortic aneurysms. Cardiovasc Surg 2002, 10:389-394
7. Baxter BT, Terrin MC, Dalman RL: Medical management of small abdominal aortic aneurysms. Circulation 2008, 117:1883-1889
8. Holmes DR, Wester W, Thompson RW, Reilly JM: Prostaglandin E2 synthesis and cyclooxygenase expression in abdominal aortic aneurysms. J Vasc Surg 1997, 25:810-815
9. King VL, Trivedi DB, Gitlin JM, Loftin CD: Selective cyclooxygenase-2 inhibition with celecoxib decreases angiotensin II-induced abdominal aortic aneurysm formation in mice. Arterioscler Thromb Vasc Biol 2006, 26:1137-1143
10. Gitlin JM, Trivedi DB, Langenbach R, Loftin CD: Genetic deficiency of cyclooxygenase-2 attenuates abdominal aortic aneurysm formation in mice. Cardiovasc Res 2007, 73:227-236
11. Morham SG, Langenbach R, Loftin CD, Tiano HF, Vouloumanos N, Jennette JC, Mahler JF, Kluckman KD, Ledford A, Lee CA, Smithies O: Prostaglandin synthase 2 gene disruption causes severe renal pathology in the mouse. Cell 1995, 83:473-482
12. Dinchuk JE, Car BD, Focht RJ, Johnston JJ, Jaffee BD, Covington MB, Contel NR, Eng VM, Collins RJ, Czerniak PM, Gorry SA, Trzaskos JM: Renal abnormalities and an altered inflammatory response in mice lacking cyclooxygenase II. Nature 1995, 378:406-409
13. Fitzgerald GA: Coxibs and cardiovascular disease. N Engl J Med 2004, 351:1709-1711
14. Grosser T, Fries S, FitzGerald GA: Biological basis for the cardiovascular consequences of COX-2 inhibition: therapeutic challenges and opportunities. J Clin Invest 2006, 116:4-15
15. Wang M, Lee E, Song W, Ricciotti E, Rader DJ, Lawson JA, Pure E, FitzGerald GA: Microsomal prostaglandin E synthase-1 deletion suppresses oxidative stress and angiotensin II-induced abdominal aortic aneurysm formation. Circulation 2008, 117:1302-1309
16. Bayston T, Ramessur S, Reise J, Jones KG, Powell JT: Prostaglandin E2 receptors in abdominal aortic aneurysm and human aortic smooth muscle cells. J Vasc Surg 2003, 38:354-359
17. Wang Y, Ait-Oufella H, Herbin O, Bonnin P, Ramkhelawon B, Taleb S, Huang J, Offenstadt G, Combadiere C, Renia L, Johnson JL, Tharaux PL, Tedgui A, Mallat Z: TGF-beta activity protects against inflammatory aortic aneurysm progression and complications in angiotensin II-infused mice. J Clin Invest 2010, 120:422-432
18. Tieu BC, Lee C, Sun H, Lejeune W, Recinos A 3rd, Ju X, Spratt H, Guo DC, Milewicz D, Tilton RG, Brasier AR: An adventitial IL-6/MCP1 amplification loop accelerates macrophage-mediated vascular inflammation leading to aortic dissection in mice. J Clin Invest 2009, 119:3637-3651
19. Shimizu K, Shichiri M, Libby P, Lee RT, Mitchell RN: Th2-predominant inflammation and blockade of IFN-gamma signaling induce aneurysms in allografted aortas. J Clin Invest 2004, 114:300-308
20. Yao C, Sakata D, Esaki Y, Li Y, Matsuoka T, Kuroiwa K, Sugimoto Y, Narumiya S: Prostaglandin E2-EP4 signaling promotes immune inflammation through Th1 cell differentiation and Th17 cell expansion. Nat Med 2009, 15:633-640
21. Sheibanie AF, Yen JH, Khayrullina T, Emig F, Zhang M, Tuma R, Ganea D: The proinflammatory effect of prostaglandin E2 in experimental inflammatory bowel disease is mediated through the IL-23→IL-17 axis. J Immunol 2007, 178:8138-8147
22. Daugherty A, Cassis LA: Mouse models of abdominal aortic aneurysms. Arterioscler Thromb Vasc Biol 2004, 24:429-434
23. Daugherty A, Manning MW, Cassis LA: Angiotensin II promotes atherosclerotic lesions and aneurysms in apolipoprotein E-deficient mice. J Clin Invest 2000, 105:1605-1612
24. Seta F, Chung AD, Turner PV, Mewburn JD, Yu Y, Funk CD: Renal and cardiovascular characterization of COX-2 knockdown mice. Am J Physiol Regul Integr Comp Physiol 2009, 296:R1751-R1760
25. Cao RY, Adams MA, Habenicht AJ, Funk CD: Angiotensin II-induced abdominal aortic aneurysm occurs independently of the 5-lipoxygenase pathway in apolipoprotein E-deficient mice. Prostaglandins Other Lipid Mediat 2007, 84:34-42
26. Daugherty A, Manning MW, Cassis LA: Antagonism of AT2 receptors augments angiotensin II-induced abdominal aortic aneurysms and atherosclerosis. Br J Pharmacol 2001, 134:865-870
27. Cao RY, Amand T, Ford MD, Piomelli U, Funk CD: The murine angiotensin II-induced abdominal aortic aneurysm model: rupture risk and inflammatory progression patterns. Front Pharmacol 2010, 1:1-9
28. Rosner, B: Fundamentals of Biostatistics. ed 7. Belmont, CA, Duxbury Press, 2011
29. Ikegami R, Sugimoto Y, Segi E, Katsuyama M, Karahashi H, Amano F, Maruyama T, Yamane H, Tsuchiya S, Ichikawa A: The expression of prostaglandin E receptors EP2 and EP4 and their different regulation by lipopolysaccharide in C3H/HeN peritoneal macrophages. J Immunol 2001, 166:4689-4696
30. Badylak SF, Valentin JE, Ravindra AK, McCabe GP, Stewart-Akers AM: Macrophage phenotype as a determinant of biologic scaffold remodeling. Tissue Eng Part A 2008, 14:1835-1842
31. Tani T, Ayuzawa R, Takagi T, Kanehira T, Maurya DK, Tamura M: Angiotensin II bi-directionally regulates cyclooxygenase-2 expression in intestinal epithelial cells. Mol Cell Biochem 2008, 315:185-193
32. Hu ZW, Kerb R, Shi XY, Wei-Lavery T, Hoffman BB: Angiotensin II increases expression of cyclooxygenase-2: implications for the function of vascular smooth muscle cells. J Pharmacol Exp Ther 2002, 303:563-573
33. Sugimoto Y, Narumiya S: Prostaglandin E receptors. J Biol Chem 2007, 282:11613-11617
34. Tang EH, Shvartz E, Shimizu K, Rocha VZ, Zheng C, Fukuda D, Shi GP, Sukhova G, Libby P: Deletion of EP4 on bone marrow-derived cells enhances inflammation and angiotensin II-induced abdominal aortic aneurysm formation. Arterioscler Thromb Vasc Biol 2011, 31:261-269
35. Esaki Y, Li Y, Sakata D, Yao C, Segi-Nishida E, Matsuoka T, Fukuda K, Narumiya S: Dual roles of PGE2-EP4 signaling in mouse experimental autoimmune encephalomyelitis. Proc Natl Acad Sci U S A 2010, 107:12233-12238
36. Chen S, Crother TR, Arditi M: Emerging role of IL-17 in atherosclerosis. J Innate Immun 2010, 2:325-333
37. Yu Y, Cheng Y, Fan J, Chen XS, Klein-Szanto A, Fitzgerald GA, Funk CD: Differential impact of prostaglandin H synthase 1 knockdown on platelets and parturition. J Clin Invest 2005, 115:986-995
38. Rateri DL, Moorleghen JJ, Balakrishnan A, Owens AP 3rd, Howatt DA, Subramanian V, Poduri A, Charnigo R, Cassis LA, Daugherty A: Endothelial cell-specific deficiency of Ang II type 1a receptors attenuates Ang II-induced ascending aortic aneurysms in LDL receptor -/- mice. Circ Res 2011, 108:574-581