Tyrosine-mutant AAV8 delivery of human MERTK provides long-term retinal preservation in RCS rats.

Investigative ophthalmology & visual science

Volumn 53, Issue 4, 2012, Pages 1895-1904

  Deng, Wen Tao ^a   Dinculescu, Astra ^b   Li, Qiuhong ^b   Boye, Sanford L ^b   Li, Jie ^b   Gorbatyuk, Marina S ^b   Pang, Jijing ^b   Chiodo, Vince A ^b   Matthes, Michael T ^b   Yasumura, Douglas ^b   Liu, L ^b   Alkuraya, Fowzan S ^b   Zhang, Kang ^b   Vollrath, Douglas ^b   LaVail, Matthew M ^b   Hauswirth, William W ^b  

^a UNIVERSITY OF FLORIDA COLLEGE OF MEDICINE   (United States)

^b NONE

Author keywords

[No Author keywords available]

Indexed keywords

MERTK PROTEIN, HUMAN; ONCOPROTEIN; PROTEIN TYROSINE KINASE; RNA; TYROSINE;

ANIMAL; ARTICLE; COMPARATIVE STUDY; DISEASE MODEL; DRUG EFFECT; ELECTRORETINOGRAPHY; FOLLOW UP; GENE THERAPY; GENE VECTOR; GENETICS; HUMAN; IMMUNOHISTOCHEMISTRY; INJECTION; METABOLISM; METHODOLOGY; MUTATION; NEWBORN; OPTICAL COHERENCE TOMOGRAPHY; PIGMENT EPITHELIUM; PLASMID; RAT; RAT STRAIN; RETINA; RETINITIS PIGMENTOSA; REVERSE TRANSCRIPTION POLYMERASE CHAIN REACTION; TIME; TRANSGENE; TRANSMISSION ELECTRON MICROSCOPY; ULTRASTRUCTURE; WESTERN BLOTTING;

ANIMALS; ANIMALS, NEWBORN; BLOTTING, WESTERN; DISEASE MODELS, ANIMAL; ELECTRORETINOGRAPHY; FOLLOW-UP STUDIES; GENE THERAPY; GENETIC VECTORS; HUMANS; IMMUNOHISTOCHEMISTRY; INJECTIONS; MICROSCOPY, ELECTRON, TRANSMISSION; MUTATION; PLASMIDS; PROTO-ONCOGENE PROTEINS; RATS; RATS, MUTANT STRAINS; RECEPTOR PROTEIN-TYROSINE KINASES; RETINA; RETINAL PIGMENT EPITHELIUM; RETINITIS PIGMENTOSA; REVERSE TRANSCRIPTASE POLYMERASE CHAIN REACTION; RNA; TIME FACTORS; TOMOGRAPHY, OPTICAL COHERENCE; TRANSGENES; TYROSINE;

EID: 84862658514     PISSN: None     EISSN: 15525783     Source Type: Journal    
DOI: 10.1167/iovs.11-8831     Document Type: Article

References (0)