Evaluating contemporary antibiotics as a risk factor for Clostridium difficile infection in surgical trauma patients

Journal of Trauma and Acute Care Surgery

Volumn 72, Issue 3, 2012, Pages 691-695

  Shah, Kruti ^a   Pass, Leigh Ann ^a   Cox, Mark ^a   Lanham, Matthew ^b   Arnold, Forest W ^c  

^a University of Louisville Health Care   (United States)

^b VIRGINIA POLYTECHNIC INSTITUTE AND STATE UNIVERSITY   (United States)

^c University of Louisville School of Medicine   (United States)

Author keywords

Antibiotics; Clostridium difficile infection; Nosocomial infection; Surgical patients

Indexed keywords

ANTIBIOTIC AGENT; CEFAZOLIN; CEFEPIME; CEFTRIAXONE; CILASTATIN PLUS IMIPENEM; CLINDAMYCIN; LEVOFLOXACIN; LINEZOLID; PIPERACILLIN PLUS TAZOBACTAM; SERUM ALBUMIN; SULTAMICILLIN; TOBRAMYCIN; VANCOMYCIN; ANTIINFECTIVE AGENT;

ADULT; ARTICLE; CLOSTRIDIUM DIFFICILE INFECTION; CONTROLLED STUDY; FEMALE; HUMAN; INFECTION RISK; MAJOR CLINICAL STUDY; MALE; PRIORITY JOURNAL; RETROSPECTIVE STUDY; SURGICAL INJURY; SURGICAL PATIENT; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTION; COMPARATIVE STUDY; CONFIDENCE INTERVAL; DRUG SCREENING; FOLLOW UP; HOSPITAL PATIENT; INCIDENCE; INJURY; ISOLATION AND PURIFICATION; LENGTH OF STAY; METHODOLOGY; MICROBIOLOGY; MIDDLE AGED; ORTHOPEDIC SURGERY; RISK; RISK FACTOR; SURGICAL INFECTION; TREATMENT OUTCOME; UNITED STATES;

ANTI-BACTERIAL AGENTS; CLOSTRIDIUM DIFFICILE; CLOSTRIDIUM INFECTIONS; CONFIDENCE INTERVALS; DRUG EVALUATION; FEMALE; FOLLOW-UP STUDIES; HUMANS; INCIDENCE; INPATIENTS; KENTUCKY; LENGTH OF STAY; MALE; MIDDLE AGED; ODDS RATIO; ORTHOPEDIC PROCEDURES; RETROSPECTIVE STUDIES; RISK FACTORS; SURGICAL WOUND INFECTION; TREATMENT OUTCOME; WOUNDS AND INJURIES;

EID: 84862657895     PISSN: 21630755     EISSN: 21630763     Source Type: Journal    
DOI: 10.1097/TA.0b013e31823c5637     Document Type: Article

References (18)

1. Dubberke E, Wertheimer A. Review of current literature on the economic burden of Clostridium difficile infection. Infect Control Hosp Epidemiol. 2009;30:57-66.
2. Henrich T, Krakower D, Bitton A, Yokoe D. Clinical risk factors for severe Clostridium difficile-associated disease. Emerg Infect Dis. 2009;15:415-422.
3. Blondeau J. What have we learned about antimicrobial use and the risks for Clostridium difficile-associated diarrhea? J Antimicrob Chemother. 2009;63:238-242.
4. Bignardi G. Risk factors for Clostridium difficile infection. J Hosp Infect. 1998;40:1-15.
5. Raveh D, Rabinowitz B, Breuer G, Rudensky B, Yinnon AM. Risk factors for Clostridium difficile toxin-positive nosocomial diarrhea. Int J Antimicrob Agents. 2006;28:231-237.
6. Gerding D. Clindamycin, cephalosporins, fluoroquinolones, and Clostridium difficile-associated diarrhea: this is an antimicrobial resistance problem. Clin Infect Dis. 2004;38:646-648.
7. Winstrom J, Norrby SR, Myhre EB, et al. Frequency of antibioticassociated diarrhea in 2642 antibiotic-treated hospitalized patients: a prospective study. J Antimicrob Chemother. 2001;47:43-50.
8. Yip C, Loeb M, Salama S, Moss L, Olde J. Quinolone use as a risk factor for nosocomial Clostridium difficile-associated diarrhea. Infect Control Hosp Epidemiol. 2001;22:572-575.
9. McCusker M, Harris A, Perencevich E, Roghmann M. Fluoroquinolone use and Clostridium difficile-associated diarrhea. Emerg Infect Dis. 2003;9:730-733.
10. Muto CA, Pokrywka M, Shutt K, et al. A large outbreak of Clostridium difficile-associated disease with an unexpected proportion of deaths and colectomies at a teaching hospital following increased fluoroquinolone use. Infect Control Hosp Epidemiol. 2005;26:273-280.
11. Owens RC Jr, Donskey CJ, Gaynes RP, Loo VG, Muto CA. Antimicrobial associated risk factors for Clostridium difficile infection. Clin Infect Dis. 2008;46 (suppl 1):S19-S31.
12. Garey K, Sethi S, Yadav Y, DuPont H. Meta-analysis to assess risk factors for recurrent Clostridium difficile infection. J Hosp Infect. 2008;70:298-304.
13. Privitera G, Scarpellini P, Ortisi G, Nicastro G, Nicolin R, de Lalla F. Prospective study of Clostridium difficile intestinal colonization and disease following single-dose antibiotic prophylaxis surgery. Antimicrob Agents Chemother. 1991;35:208-210.
14. Carignan A, Allard C, Pépin J, Cossette B, Nault V, Valiquette L. Risk of Clostridium difficile infection after perioperative antibacterial prophylaxis before and during an outbreak of infection due to a hypervirulent strain. Clin Infect Dis. 2008;46:1838-1843.
15. Harbarth S. Samore MH, Carmeli Y. Antibiotic prophylaxis and the risk of Clostridium difficile-associated diarrhea. J Hosp Infect. 2001;48:93-97.
16. Dial S, Delaney JA, Barkun AN, Suissa S. Use of gastric acid-suppressive agents and the risk of community-acquired Clostridium difficile-associated disease. JAMA. 2005;294:2989-2995.
17. Gerding DN, Johnson S, Peterson LR, Mulligan ME, Silva J Jr. Clostridium difficile-associated diarrhea and colitis. Infect Control Hosp Epidemiol. 1995;16:459-477.
18. Cohen S, Gerding D, Johnson S, et al; Society for Healthcare Epidemiology of America; Infectious Diseases Society of America. Clinical practice guidelines for Clostridium difficile infection in adults: 2010 update by the Society of Healthcare Epidemiology of America (SHEA) and the Infectious Diseases Society of America (IDSA). Infect Control Hosp Epidemiol. 2010;31:431-455.