The effect of low dose human chorionic gonadotropin on follicular response and oocyte maturation in PCOS patients undergoing IVF cycles: A randomized clinical trial of efficacy and safety

Archives of Gynecology and Obstetrics

Volumn 284, Issue 6, 2011, Pages 1431-1438

  Ashrafi, Mahnaz ^a,b   Kiani, Kiandokht ^a   Ghasemi, Afsaneh ^b   Rastegar, Fatemeh ^a   Nabavi, Maryam ^a  

^a ROYAN INSTITUTE FOR REPRODUCTIVE BIOMEDICINE   (Iran)

^b IRAN UNIVERSITY OF MEDICAL SCIENCES   (Iran)

Author keywords

Follicular response; Low dose hCG; Oocyte maturation; Polycystic ovarian syndrome

Indexed keywords

CHORIONIC GONADOTROPIN; ESTRADIOL; FOLLITROPIN; RECOMBINANT FOLLITROPIN; TESTOSTERONE; RECOMBINANT PROTEIN;

ARTICLE; CELL STIMULATION; COMPARATIVE EFFECTIVENESS; CONTROLLED STUDY; COST EFFECTIVENESS ANALYSIS; DRUG DOSE REDUCTION; DRUG EFFICACY; DRUG SAFETY; FEMALE; FEMALE GENITAL TRACT PARAMETERS; FERTILIZATION IN VITRO; FOLLICLE DIAMETER; FOLLICULAR PHASE; FOLLITROPIN BLOOD LEVEL; HUMAN; LOW DRUG DOSE; MAJOR CLINICAL STUDY; MONOTHERAPY; NIDATION; OOCYTE MATURATION; OVARY FOLLICLE DEVELOPMENT; OVARY HYPERSTIMULATION; OVARY POLYCYSTIC DISEASE; OVULATION INDUCTION; PREGNANCY RATE; PROSPECTIVE STUDY; RANDOMIZED CONTROLLED TRIAL; TESTOSTERONE BLOOD LEVEL; TREATMENT DURATION; ADULT; CLINICAL TRIAL; COMPARATIVE STUDY; CONTROLLED CLINICAL TRIAL; DRUG EFFECT; GROWTH, DEVELOPMENT AND AGING; OOCYTE DEVELOPMENT; OVARY FOLLICLE; PATHOPHYSIOLOGY; PREGNANCY; TREATMENT OUTCOME;

ADULT; CHORIONIC GONADOTROPIN; FEMALE; FERTILIZATION IN VITRO; FOLLICLE STIMULATING HORMONE; HUMANS; OOGENESIS; OVARIAN FOLLICLE; OVULATION INDUCTION; POLYCYSTIC OVARY SYNDROME; PREGNANCY; PROSPECTIVE STUDIES; RECOMBINANT PROTEINS; TREATMENT OUTCOME;

EID: 84862597322     PISSN: 09320067     EISSN: 14320711     Source Type: Journal    
DOI: 10.1007/s00404-010-1827-0     Document Type: Article

References (31)

1. Van der Meer M, Hompes PG, De Boer JA, Schats R, Schoemaker J (1998) Cohort size rather than follicle-stimulating hormone threshold level determines ovarian sensitivity in polycystic ovary syndrome. J Clin Endocrinol Metab 83:423-426 (Pubitemid 28496516)
2. Filicori M, Cognigni GE, Tabarelli C, Pocognoli P, Taraborrelli S, Spettoli D, Ciampaglia W (2002) Stimulation and growth of antral ovarian follicles by selective LH activity administration in women. J Clin Endocrinol Metab 87:1156-1161 (Pubitemid 36121081)
3. Filicori M, Cognigni GE, Taraborrelli S, Parmegiani L, Bernardi S, Ciampaglia W (2002) Intracytoplasmic sperm injection pregnancy after low-dose human chorionic gonadotropin alone to support ovarian folliculogenesis. Fertil Steril 78:414-416 (Pubitemid 34831746)
4. Filicori M, Cognigni GE, Gamberini E, Parmegiani L, Troilo E, Roset B (2005) Efficacy of low-dose human chorionic gonadotropin alone to complete controlled ovarian stimulation. Fertil Steril 84:394-401 (Pubitemid 41125260)
5. Lee KL, Couchman GM, Walmer DK (2005) Successful pregnancies in patients with estrogenic anovulation after low-dose human chorionic gonadotropin therapy alone following hMG for controlled ovarian hyperstimulation. J Assist Reprod Genet 22:37-40 (Pubitemid 40558077)
6. Sullivan MW, Stewart-Akers A, Krasnow JS, Berga SL, Zeleznik AJ (1999) Ovarian responses in women to recombinant folliclestimulating hormone and luteinizing hormone (LH): a role for LH in the final stages of follicular maturation. J Clin Endocrinol Metab 84:228-232 (Pubitemid 29036707)
7. Zeleznik AJ, Hillier SG (1984) The role of gonadotropins in the selection of the preovulatory follicle. Clin Obstet Gynecol 27:927-940 (Pubitemid 15224078)
8. Thompson KA, LaPolt PS, River J, Henderson G, Dahl KD, Meldrum DR (1995) Gonadotropin requirements of the developing follicle. Fertil Steril 63:273-276
9. Branigan EF, Estes A (2005) Use of micro-dose human chorionic gonadotropin (hCG) after clomiphene citrate (CC) to complete folliculogenesis in previous CC-resistant anovulation. Am J Obstet Gynecol 192:1890-1894.
10. The Rotterdam ESHRE/ASRM-Sponsored PCOS Consensus Workshop Group (2004) Revised 2003 consensus on diagnostic criteria and long-term health risks related to polycystic ovary syndrome. Fertil Steril 81:19-25
11. World Health Organization (2001) Laboratory manual of the WHO for the examination of human semen and sperm-cervical mucus interaction. Ann Ist Super Sanita 37: I-XII, 1-123
12. Madani T, Ashrafi M, Abadi AB, Kiani K (2009) Appropriate timing of uterine cavity length measurement positively affects assisted reproduction cycle outcome. Reprod Biomed Online 19:734-736
13. Baczkowski T, Kurzawa R, Glabowski W (2004) Methods of embryo scoring in in vitro fertilization. Reprod Biol 4:5-22
14. Veeck LL (1992) Oocyte quality and assisted conception. Acta Eur Fertil 23:275-288
15. Aboulghar MA, Mansour RT (2003) Ovarian hyperstimulation syndrome: classifications and critical analysis of preventive measures. Hum Reprod Update 9:275-289 (Pubitemid 36827064)
16. Filicori M (1999) The role of luteinizing hormone in folliculogenesis and ovulation induction. Fertil Steril 71:405-414 (Pubitemid 29094112)
17. The European and Israeli Study Group on Highly Purified Menotropin versus Recombinant Follicle-Stimulating Hormone (2002) Efficacy and safety of highly purified menotropin versus recombinant follicle-stimulating hormone in in vitro fertilization/intracytoplasmic sperm injection cycles: a randomized, comparative trial. Fertil Steril 78:520-528
18. Agrawal R, Holmes J, Jacobs HS (2000) Follicle-stimulating hormone or human menopausal gonadotropin for ovarian stimulation in in vitro fertilization cycles: a meta-analysis. Fertil Steril 73:338-343 (Pubitemid 30060370)
19. Kilani Z, Dakkak A, Ghunaim S, Cognigni GE, Tabarelli C, Parmegiani L, Filicori M (2003) A prospective, randomized, controlled trial comparing highly purified hMG with recombinant FSH in women undergoing ICSI: ovarian response and clinical outcomes. Hum Reprod 18:1194-1199 (Pubitemid 36740563)
20. Ng EH, Lau EY, Yeung WS, Ho PC (2001) HMG is as good as recombinant human FSH in terms of oocyte and embryo quality: a prospective randomized trial. Hum Reprod 16:319-325 (Pubitemid 32149428)
21. Zeleznik AJ (2001) Follicle selection in primates: "many are called but few are chosen". Biol Reprod 65:655-659 (Pubitemid 32777347)
22. Yoshimura Y, Wallach EE (1987) Studies of the mechanism (s) of mammalian ovulation. Fertil Steril 47:22-34
23. Kyono K, Fuchinou K, Nakaj Y, Yag A, Sasaki K (2004) A prospective randomized study of three ovulation induction protocols for IVF: GnRH agonist versus antagonist with and without low dose hCG. Fertil Steril 82:S31
24. Serafini P, Yadid I, Motta EL, Alegretti JR, Fioravanti J, Coslovsky M (2006) Ovarian stimulation with daily late follicular phase administration of low-dose human chorionic gonadotropin for in vitro fertilization: a prospective, randomized trial. Fertil Steril 86:830-838 (Pubitemid 44485029)
25. Commenges-Ducos M, Piault S, Papaxanthos A, Ribes C, Dallay D, Commenges D (2002) Recombinant follicle-stimulating hormone versus human menopausal gonadotropin in the late follicular phase during ovarian hyperstimulation for in vitro fertilization. Fertil Steril 78:1049-1054 (Pubitemid 35292508)
26. Gordon UD, Harrison RF, Fawzy M, Hennelly B, Gordon AC (2001) A randomized prospective assessor-blind evaluation of luteinizing hormone dosage and in vitro fertilization outcome. Fertil Steril 75:324-331 (Pubitemid 32112109)
27. Mitwally MF, Casper RF (2004) Aromatase inhibition reduces the dose of gonadotropin required for controlled ovarian hyperstimulation. J Soc Gynecol Invest 11:406-415. (Pubitemid 39179897)
28. Nargund G, Hutchison L, Scaramuzzi R, Campbell S (2007) Low-dose HCG is useful in preventing OHSS in high-risk women without adversely affecting the outcome of IVF cycles. Reprod Biomed Online 14:682-685 (Pubitemid 46951700)
29. Gomez R, Lima I, Simon C, Pellicer A (2004) Administration of low-dose LH induces ovulation and prevents vascular hyperpermeability and vascular endothelial growth factor expression in superovulated rats. Reproduction 127:483-489. (Pubitemid 38495770)
30. Stokman PG, de Leeuw R, van den Wijngaard HA, Kloosterboer HJ, Vemer HM, Sanders AL (1993) Human chorionic gonadotropin in commercial human menopausal gonadotropin preparations. Fertil Steril 60:175-178 (Pubitemid 23198942)
31. Filicori M, Cognigni GE, Pocognoli P, Tabarelli C, Spettoli D, Taraborrelli S, Ciampaglia W (2002) Modulation of folliculogenesis and steroidogenesis in women by graded menotropin administration. Hum Reprod 17:2009-2015