Trichomonas vaginalis: Current understanding of host-parasite interactions

Essays in Biochemistry

Volumn 51, Issue 1, 2011, Pages 161-175

  Ryan, Christopher M ^a   De Miguel, Natalia ^a   Johnson, Patricia J ^a  

^a UNIVERSITY OF CALIFORNIA   (United States)

Author keywords

[No Author keywords available]

Indexed keywords

TRICHOMONAS; TRICHOMONAS VAGINALIS;

GLYCOSPHINGOLIPID; LIPOPHOSPHOGLYCAN; MEMBRANE PROTEIN; PROTEOME; PROTOZOAL PROTEIN;

GENETICS; GENOME; HOST PARASITE INTERACTION; HUMAN; METABOLISM; PARASITOLOGY; PATHOGENICITY; REVIEW; TRICHOMONAS VAGINALIS; TRICHOMONIASIS;

GENOME; GLYCOSPHINGOLIPIDS; HOST-PARASITE INTERACTIONS; HUMANS; MEMBRANE PROTEINS; PROTEOME; PROTOZOAN PROTEINS; TRICHOMONAS INFECTIONS; TRICHOMONAS VAGINALIS;

EID: 84862589351     PISSN: 00711365     EISSN: None     Source Type: Journal    
DOI: 10.1042/BSE0510161     Document Type: Article

References (53)

1. Petrin, D., Delgaty, K., Bhatt, R. and Garber, G. (1998) Clinical and microbiological aspects of Trichomonas vaginalis. Clin. Microbiol. Rev. 11, 300-317
2. Soper, D. (2004) Trichomoniasis: under control or undercontrolled? Am. J. Obstet. Gynecol. 190, 281-290
3. Lloyd, G.L., Case, J.R., De Frias, D. and Brannigan, R.E. (2003) Trichomonas vaginalis orchitis with associated severe oligoasthenoteratospermia and hypogonadism. J. Urol. 170, 924
4. Sutcliffe, S., Giovannucci, E., Alderete, J.F., Chang, T.H., Gaydos, C.A., Zenilman, J.M., de Marzo, A.M., Willett, W.C. and Platz, E.A. (2006) Plasma antibodies against Trichomonas vaginalis and subsequent risk of prostate cancer. Cancer Epidemiol. Biomarkers Prev. 15, 939-945
5. Pereira-Neves, A. and Benchimol, M. (2007) Phagocytosis by Trichomonas vaginalis: new insights. Biol. Cell 99, 87-101
6. da Costa, R.F., de Souza, W., Benchimol, M., Alderete, J.F. and Morgado-Diaz, J.A. (2005) Trichomonas vaginalis perturbs the junctional complex in epithelial cells. Cell Res. 15, 704-716
7. Provenzano, D. and Alderete, J.F. (1995) Analysis of human immunoglobulin-degrading cysteine proteinases of Trichomonas vaginalis. Infect. Immun. 63, 3388-3395
8. Carlton, J.M., Hirt, R.P., Silva, J.C., Delcher, A.L., Schatz, M., Zhao, Q., Wortman, J.R., Bidwell, S.L., Alsmark, U.C. M., Besteiro, S. et al. (2007) Draft genome sequence of the sexually transmitted pathogen Trichomonas vaginalis. Science 315, 207-212
9. de Miguel, N., Lustig, G., Twu, O., Chattopadhyay, A., Wohlschlegel, J.A. and Johnson, P.J. (2010) Proteome analysis of the surface of Trichomonas vaginalis reveals novel proteins and strain-dependent differential expression. Mol. Cell. Proteomics 9, 1554-1566
10. De Jesus, J.B., Cuervo, P., Britto, C., Saboia-Vahia, L., Costa, E.S.-F. F., Borges-Veloso, A., Barreiros Petropolis, D., Cupolillo, E. and Barbosa Domont, G. (2009) Cysteine peptidase expression in Trichomonas vaginalis isolates displaying high- and low-virulence phenotypes. J. Proteome Res. 8, 1555-1564
11. Cuervo, P., Cupolillo, E., Britto, C., González, L.J., E Silva-Filo, F.C., Lopes, L.C., Domont, G.B. and De Jesus, J.B. (2008) Differential soluble protein expression between Trichomonas vaginalis isolates exhibiting low and high virulence phenotypes. J. Proteomics 71, 109-122
12. Ramon-Luing, L.A., Rendon-Gandarilla, F.J., Cardenas-Guerra, R.E., Rodriguez-Cabrera, N.A., Ortega-Lopez, J., Avila-Gonzalez, L., Angel-Ortiz, C., Herrera-Sanchez, C.N., Mendoza-Garcia, M. and Arroyo, R. (2010) Immunoproteomics of the active degradome to identify biomarkers for Trichomonas vaginalis. Proteomics 10, 435-444
13. Hirt, R.P., Noel, C.J., Sicheritz-Ponten, T., Tachezy, J. and Fiori, P.L. (2007) Trichomonas vaginalis surface proteins: a view from the genome. Trends Parasitol. 23, 540-547
14. Crouch, M.L. and Alderete, J.F. (1999) Trichomonas vaginalis interactions with fibronectin and laminin. Microbiology 145, 2835-2843
15. Shiflett, A.M. and Johnson, P.J. (2010) Mitochondrion-related organelles in eukaryotic protists. Annu. Rev. Microbiol. 64, 409-429
16. Engbring, J.A. and Alderete, J.F. (1998) Characterization of Trichomonas vaginalis AP33 adhesin and cell surface interactive domains. Microbiology 144, 3011-3018
17. Garcia, A.F. and Alderete, J. (2007) Characterization of the Trichomonas vaginalis surface-associated AP65 and binding domain interacting with trichomonads and host cells. BMC Microbiol. 7, 116
18. Alderete, J.F., Millsap, K.W., Lehker, M.W. and Benchimol, M. (2001) Enzymes on microbial pathogens and Trichomonas vaginalis: molecular mimicry and functional diversity. Cell. Microbiol. 3, 359-370
19. Addis, M.F., Rappelli, P. and Fiori, P.L. (2000) Host and tissue specificity of Trichomonas vaginalis is not mediated by its known adhesion proteins. Infect. Immun. 68, 4358-4360
20. Ardalan, S., Lee, B.C. and Garber, G.E. (2009) Trichomonas vaginalis: the adhesins AP51 and AP65 bind heme and hemoglobin. Exp. Parasitol. 121, 300-306
21. Lama, A., Kucknoor, A., Mundodi, V. and Alderete, J.F. (2009) Glyceraldehyde-3-phosphate dehydrogenase is a surface-associated, fibronectin-binding protein of Trichomonas vaginalis. Infect. Immun. 77, 2703-2711
22. Warton, A. and Honigberg, B.M. (1980) Lectin analysis of surface saccharides in two Trichomonas vaginalis strains differing in pathogenicity. J. Protozool. 27, 410-419
23. Warton, A., Kon, V.B. and Papadimitriou, J.M. (1988) Demonstration of concanavalin A- and wheat germ agglutinin-binding sites on the Trichomonas vaginalis surface coat using lectin-gold particle conjugates. J. Electron Microsc. (Tokyo) 37, 134-140
24. Gilbert, R.O., Elia, G., Beach, D.H., Klaessig, S. and Singh, B.N. (2000) Cytopathogenic effect of Trichomonas vaginalis on human vaginal epithelial cells cultured in vitro. Infect. Immun. 68, 4200-4206
25. Singh, B.N., Lucas, J.J., Beach, D.H., Shin, S.T. and Gilbert, R.O. (1999) Adhesion of Tritrichomonas foetus to bovine vaginal epithelial cells. Infect. Immun. 67, 3847-3854
26. Singh, B.N. (1993) Lipophosphoglycan-like glycoconjugate of Tritrichomonas foetus and Trichomonas vaginalis. Mol. Biochem. Parasitol. 57, 281-294
27. Singh, B.N., Beach, D.H., Lindmark, D.G. and Costello, C.E. (1994) Identification of the lipid moiety and further characterization of the novel lipophosphoglycan-like glycoconjugates of Trichomonas vaginalis and Trichomonas foetus. Arch. Biochem. Biophys. 309, 273-280
28. Bastida-Corcuera, F.D., Okumura, C.Y., Colocoussi, A. and Johnson, P.J. (2005) Trichomonas vaginalis lipophosphoglycan mutants have reduced adherence and cytotoxicity to human ectocervical cells. Eukaryot. Cell 4, 1951-1958
29. Fichorova, R.N., Trifonova, R.T., Gilbert, R.O., Costello, C.E., Hayes, G.R., Lucas, J.J. and Singh, B.N. (2006) Trichomonas vaginalis lipophosphoglycan triggers a selective upregulation of cytokines by human female reproductive tract epithelial cells. Infect. Immun. 74, 5773-5779
30. Singh, B.N., Hayes, G.R., Lucas, J.J., Sommer, U., Viseux, N., Mirgorodskaya, E., Trifonova, R.T., Sassi, R.R., Costello, C.E. and Fichorova, R.N. (2009) Structural details and composition of Trichomonas vaginalis lipophosphoglycan in relevance to the epithelial immune function. Glycoconj. J. 26, 3-17
31. Okumura, C.Y. M., Baum, L.G. and Johnson, P.J. (2008) Galectin-1 on cervical epithelial cells is a receptor for the sexually transmitted human parasite Trichomonas vaginalis. Cell. Microbiol. 10, 2078-2090
32. Fichorova, R.N. (2009) Impact of T. vaginalis infection on innate immune responses and reproductive outcome. J. Reprod. Immunol. 83, 185-189
33. Alderete, J.F. and Garza, G.E. (1985) Specific nature of Trichomonas vaginalis parasitism of host cell surfaces. Infect. Immun. 50, 701-708
34. Kim, K. (2004) Role of proteases in host cell invasion by Toxoplasma gondii and other apicomplexa. Acta Tropica 91, 69-81
35. Bonilha, V.L., Ciavaglia Mdo, C., de Souza, W. and Costa e Silva Filho, F. (1995) The involvement of terminal carbohydrates of the mammalian cell surface in the cytoadhesion of trichomonads. Parasitol. Res. 81, 121-126
36. Noel, C.J., Diaz, N., Sicheritz-Ponten, T., Safarikova, L., Tachezy, J., Tang, P., Fiori, P.L. and Hirt, R.P. (2010) Trichomonas vaginalis vast BspA-like gene family: evidence for functional diversity from structural organisation and transcriptomics. BMC Genomics 11, 99
37. De Jesus, J.B., Cuervo, P., Junqueira, M., Britto, C., Silva-Filho, F.C., Soares, M.J., Cupolillo, E., Fernandes, O. and Domont, G.B. (2007) A further proteomic study on the effect of iron in the human pathogen Trichomonas vaginalis. Proteomics 7, 1961-1972
38. De Jesus, J.B., Cuervo, P., Junqueira, M., Britto, C., Silva-Filho, F.C., Saboia-Vahia, L., Gonzalez, L.J. and Barbosa Domont, G. (2007) Application of two-dimensional electrophoresis and matrixassisted laser desorption/ionization time-of-flight mass spectrometry for proteomic analysis of the sexually transmitted parasite Trichomonas vaginalis. J. Mass Spectrom. 42, 1463-1473
39. Huang, K.Y., Chien, K.Y., Lin, Y.C., Hsu, W.M., Fong, I.K., Huang, P.J., Yueh, Y.M., Gan, R.R. and Tang, P. (2009) A proteome reference map of Trichomonas vaginalis. Parasitol. Res. 104, 927-933
40. Henze, K. (2007) The proteome of T. vaginalis hydrogenosomes. In Microbiology Monographs (Tachezy, J., ed.), pp. 163-176, Springer, Berlin
41. Hemler, M.E. (2003) Tetraspanin proteins mediate cellular penetration, invasion, and fusion events and define a novel type of membrane microdomain. Annu. Rev. Cell Dev. Biol. 19, 397-422
42. Freeman, M. (2008) Rhomboid proteases and their biological functions. Annu. Rev. Genet. 42, 191-210
43. Xia, W. and Wolfe, M.S. (2003) Intramembrane proteolysis by presenilin and presenilin-like proteases. J. Cell Sci. 116, 2839-2844
44. Tran, M.H., Pearson, M.S., Jeffrey, M.B., Smyth, D.J., Jones, M.K., Duke, M., Don, T.A., McManus, D.P., Correa-Oliveira, R. and Loukas, A. (2006) Tetraspanins on the surface of Schistosoma mansoni are protective antigens against schistosomiasis. Nat. Med. 12, 835-840
45. Baxt, L.A., Baker, R.P., Singh, U. and Urban, S. (2008) An Entamoeba histolytica rhomboid protease with atypical specificity cleaves a surface lectin involved in phagocytosis and immune evasion. Genes Dev. 22, 1636-1646
46. Henderson, I.R. and Lam, A.C. (2001) Polymorphic proteins of Chlamydia spp. - autotransporters beyond the Proteobacteria. Trends Microbiol. 9, 573-578
47. Alderete, J.F., Newton, E., Dennis, C. and Neale, K.A. (1991) The vagina of women infected with Trichomonas vaginalis has numerous proteinases and antibody to trichomonad proteinases. Genitourin. Med. 67, 469-474
48. Kummer, S., Hayes, G.R., Gilbert, R.O., Beach, D.H., Lucas, J.J. and Singh, B.N. (2008) Induction of human host cell apoptosis by Trichomonas vaginalis cysteine proteases is modulated by parasite exposure to iron. Microb. Pathog. 44, 197-203
49. Sommer, U., Costello, C.E., Hayes, G.R., Beach, D.H., Gilbert, R.O., Lucas, J.J. and Singh, B.N. (2005) Identification of Trichomonas vaginalis cysteine proteases that induce apoptosis in human vaginal epithelial cells. J. Biol. Chem. 280, 23853-23860
50. Kucknoor, A.S., Mundodi, V. and Alderete, J.F. (2007) The proteins secreted by Trichomonas vaginalis and vaginal epithelial cell response to secreted and episomally expressed AP65. Cell. Microbiol. 9, 2586-2597
51. Hernandez-Gutierrez, R., Avila-Gonzalez, L., Ortega-Lopez, J., Cruz-Talonia, F., Gomez-Gutierrez, G. and Arroyo, R. (2004) Trichomonas vaginalis: characterization of a 39-kDa cysteine proteinase found in patient vaginal secretions. Exp. Parasitol. 107, 125-135
52. Alvarez-Sanchez, M.E., Avila-Gonzalez, L., Becerril-Garcia, C., Fattel-Facenda, L.V., Ortega-Lopez, J. and Arroyo, R. (2000) A novel cysteine proteinase (CP65) of Trichomonas vaginalis involved in cytotoxicity. Microb. Pathog. 28, 193-202
53. Sajid, M. and McKerrow, J.H. (2002) Cysteine proteases of parasitic organisms. Mol. Biochem. Parasitol. 120, 1-21