Cerebrospinal fluid findings in adults with acute Lyme neuroborreliosis

Journal of Neurology

Volumn 259, Issue 4, 2012, Pages 630-636

  Djukic, Marija ^a   Schmidt Samoa, Carsten ^b   Lange, Peter ^b   Spreer, Annette ^b   Neubieser, Katja ^b   Eiffert, Helmut ^b   Nau, Roland ^a,b   Schmidt, Holger ^b  

^a Sleep Laboratory   (Germany)

^b UNIVERSITY MEDICAL CENTER GÖTTINGEN   (Germany)

Author keywords

Acute lyme neuroborreliosis; Clinical symptoms; CSF findings

Indexed keywords

ALBUMIN; IMMUNOGLOBULIN A; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LACTIC ACID; PROTEIN;

ADULT; ARTICLE; BORRELIA BURGDORFERI; CEREBROSPINAL FLUID ANALYSIS; FACIAL NERVE PARALYSIS; FEVER; HEADACHE; HUMAN; IMMUNOGLOBULIN PRODUCTION; LEUKOCYTE COUNT; LYME DISEASE; MAJOR CLINICAL STUDY; NEURITIS; NEUROSYPHILIS; PRIORITY JOURNAL; PROTEIN CEREBROSPINAL FLUID LEVEL; RETROSPECTIVE STUDY; VIRUS MENINGITIS;

ACUTE DISEASE; ADULT; FEMALE; HUMANS; IMMUNOGLOBULIN G; IMMUNOGLOBULIN M; LACTIC ACID; LYME NEUROBORRELIOSIS; MALE; MIDDLE AGED; RETROSPECTIVE STUDIES;

EID: 84862577300     PISSN: 03405354     EISSN: 14321459     Source Type: Journal    
DOI: 10.1007/s00415-011-6221-8     Document Type: Article

References (28)

1. Hansen K, Lebech AM (1992) The clinical and epidemiological profile of Lyme neuroborreliosis in Denmark 1985-1990. A prospective study of 187 patients with Borrelia burgdorferi specific intrathecal antibody production. Brain 115:399-423. doi: 10.1093/brain/115.2.399
2. Ljostad U, Skarpaas T, Mygland A (2007) Clinical usefulness of intrathecal antibody testing in acute Lyme neuroborreliosis. Eur J Neurol 14:873-876. doi:10.1111/j.1468-1331.2007.01799.x (Pubitemid 47106769)
3. Rauer S (2008) Neuroboreliose. In: Diener HC, Putzki N (eds) Leitlinien für die diagnostik und therapie in der neurologie, 3rd edn. Georg Thieme Verlag, Stuttgart, pp 415-423
4. Blanc F, Jaulhac B, Fleury M et al (2007) Relevance of the antibody index to diagnose Lyme neuroborreliosis among seropositive patients. Neurology 69:953-958. doi:10.1212/01. wnl.0000269672.17807.e0 (Pubitemid 47366047)
5. Centers for Disease Control and Prevention (1998) Summary of notifiable diseases, United States, 1997. MMWR Morb Mortal Wkly Rep 46:3-87
6. Steere AC, Berardi VP, Weeks KE, Logigian EL, Ackermann R (1990) Evaluation of the intrathecal antibody response to Borrelia burgdorferi as a diagnostic test for Lyme neuroborreliosis. J Infect Dis 161:1203-1209. doi:10.1093/infdis/161.6.1203 (Pubitemid 20177881)
7. Aguero-Rosenfeld ME, Wang G, Schwartz I, Wormser GP (2005) Diagnosis of lyme borreliosis. Clin Microbiol Rev 18:484-509. doi:10.1128/CMR.18.3.484-509. 2005 (Pubitemid 40995113)
8. Hammers-Berggren S, Hansen K, Lebech AM, Karlsson M (1993) Borrelia burgdorferi-specific intrathecal antibody production in neuroborreliosis: a follow-up study. Neurology 43:169-175 (Pubitemid 23035376)
9. Kruger H, Reuss K, Pulz M, Rohrbach E, Pflughaupt KW, Martin R, Mertens HG (1989) Meningoradiculitis and encephalomyelitis due to Borrelia burgdorferi: a follow-up study of 72 patients over 27 years. J Neurol 236:322-328. doi:10.1007/BF00314373 (Pubitemid 19211314)
10. Rupprecht TA, Pfister HW, Angele B, Kastenhauer S, Wilske B, Koedel U (2005) The chemokine CXCL 13 (BLC): a putative diagnostic marker for neuroborreliosis. Neurology 65:448-450 (Pubitemid 41099810)
11. Senel M, Rupprecht TA, Tumani H, Pfister HW, Ludolph AC, Brettschneider J (2010) The chemokine CXCL13 in acute neuroborreliosis. J Neurol Neurosurg Psychiatry 81:929-933. doi: 10.1136/jnnp.2009.195438
12. Sipe JC, Knobler RL, Braheny SL, Rice GP, Panitch HS, Oldstone MB (1984) A neurologic rating scale (NRS) for use in multiple sclerosis. Neurology 34:1368-1372 (Pubitemid 14047252)
13. Wilske B, Fingerle V, Schulte-Spechtel U (2007) Microbiological and serological diagnosis of Lyme borreliosis. FEMS Immunol Med Microbiol 49:13-21. doi:10.1111/j.1574-695X.2006.00139.x (Pubitemid 46160581)
14. Reiber H, Felgenhauer K (1987) Protein transfer at the blood cerebrospinal fluid barrier and the quantitation of the humoral immune response within the central nervous system. Clin Chim Acta 163:319-328. doi:10.1016/0009-898(87)90250-6 (Pubitemid 17050086)
15. Kaiser R, Lücking CH (1993) Intrathecal synthesis of specific antibodies in neuroborreliosis. Comparison of different ELISA techniques and calculation methods. J Neurol Sci 118:64-72. doi: 10.1016/0022-510X(93)90247-V (Pubitemid 23269968)
16. Reiber H, Lange P (1991) Quantification of virus-specific antibodies in cerebrospinal fluid and serum: sensitive and specific detection of antibody synthesis in brain. Clin Chem 37:1153-1160 (Pubitemid 21925939)
17. Reiber H (2005) Proteindiagnostik. In: Zettl U, Lehmnitz R, Mix E (eds) Klinische Liquordiagnostik, 2nd edn. Walter de Gruyter, New York, pp 177-248
18. Tumani H, Nölker G, Reiber H (1995) Relevance of cerebrospinal fluid variables for early diagnosis of neuroborreliosis. Neurology 45:1663-1670
19. Christen HJ, Hanefeld F, Eiffert H, Thomsen R (1993) Epidemiology and clinical manifestations of Lyme-Borreliosis in childhood-A prospective multicentre study with special regard of neuroborreliosis. Acta Paediatr Scand 82:1-75. doi:10.1111/j.1651-2227.1993.tb18082.x (Pubitemid 23072307)
20. Lebech AM, Hansen K, Brandrup F, Clemmensen O, Halkier-Sørensen L (2000) Diagnostic value of PCR for detection of Borrelia burgdorferi DNA in clinical specimens from patients with erythema migrans and Lyme neuroborreliosis. Mol Diagn 5:139-150
21. Coyle PK, Schutzer SE, Deng Z, Krupp LB, Belman AL, Benach JL, Luft BJ (1995) Detection of Borrelia burgdorferi-specific antigen in antibody-negative cerebrospinal fluid in neurologic Lyme disease. Neurology 45:2010-2015
22. Hansen K, Lebech AM (1991) Lyme neuroborreliosis: a new sensitive diagnostic assay for intrathecal synthesis of Borreliaburgdorferi-specific immunoglobulin G, A, and M. Ann Neurol 30:197-205. doi:10.1002/ana.410300212
23. Steere AC (1993) Seronegative Lyme disease. JAMA 270:1369. doi:10.1001/jama.1993.03510110111042 (Pubitemid 23267900)
24. Baig S, Olsson T, Hansen K, Link H (1991) Anti-Borrelia burgdorferi antibody response over the course of Lyme neuroborreliosis. Infect Immun 59:1050-1056
25. Cepok S, Zhou D, Vogel F, Rosche B, Grummel V, Sommer N, Hemmer B (2003) The immune response at onset and during recovery from Borrelia burgdorferi meningoradiculitis. Arch Neurol 60:849-855 (Pubitemid 36705973)
26. Bannwarth A (1941) Chronische lymphozytäre meningitis, entzündliche polyneuritis and rheumatismus. Arch Psychaitr Nervenkr 113:284-376
27. Myglanda A, Ljøstada U, Fingerled V, Rupprecht T, Schmutzhard E, Steiner I (2010) EFNS guidelines on the diagnosis and management of European Lyme neuroborreliosis. Eur J Neurol 17:8-16. doi:10.1111/j.1468-1331.2009.02862. x
28. Pfister HW, Rupprecht TA (2006) Clinical aspects of neuroborrelisis and post-Lyme disease syndrome in adult patients. Int J Med Microbiol 40:11-16. doi:10.1016/j.ijmm.2005.12.003 (Pubitemid 43668605)