Separation and detection of bis-maleimide-polyethylene glycol and mono-maleimide-polyethylene glycol by reversed-phase high pressure liquid chromatography

Journal of Chromatography A

Volumn 1246, Issue , 2012, Pages 117-122

  Tang, Liya ^a   Jariwala, Freneil ^b   Bolgar, Mark ^a   Lloyd, David K ^a  

^a BRISTOL MYERS SQUIBB   (United States)

^b STEVENS INSTITUTE OF TECHNOLOGY   (United States)

Author keywords

Bis maleimide PEG; Impurity analysis; Maleimide PEG; Mono maleimide PEG; Polyethylene glycol; Reversed phase HPLC

Indexed keywords

ANALYTES; AVERAGE MOLECULAR WEIGHT; BIS-MALEIMIDE-PEG; CHROMATOGRAPHIC SEPARATIONS; COLUMN TEMPERATURE; CRITICAL PARAMETER; LIMIT OF QUANTITATIONS; LOW LEVEL; MALEIMIDES; MOBILE PHASE; MONO-MALEIMIDE-PEG; MONOFUNCTIONAL; PEGYLATION; PROTEIN PEGYLATION; RETENTION TIME; REVERSED PHASE; REVERSED PHASE HPLC; SEPARATION CONDITION; THERAPEUTIC PROTEIN; UV CHROMOPHORES; UV DETECTION;

ACETONITRILE; CHROMATOGRAPHY; CHROMOPHORES; HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; HIGH PRESSURE LIQUID CHROMATOGRAPHY; MOLECULAR WEIGHT; PROTEINS; SEPARATION;

POLYETHYLENE GLYCOLS;

ACETONITRILE; BISFUNCTIONAL MALEIMIDE POLYETHYLENE GLYCOL; MACROGOL; MONOFUNCTIONAL MALEIMIDE POLYETHYLENE GLYCOL; PROTEIN; UNCLASSIFIED DRUG;

ACCURACY; ARTICLE; CONTROLLED STUDY; DERIVATIZATION; DISPERSION; LIMIT OF QUANTITATION; MOLECULAR WEIGHT; PRIORITY JOURNAL; PROTEIN MODIFICATION; PROTEIN PEGYLATION; REVERSED PHASE HIGH PERFORMANCE LIQUID CHROMATOGRAPHY; SENSITIVITY AND SPECIFICITY; TEMPERATURE;

CHROMATOGRAPHY, HIGH PRESSURE LIQUID; CHROMATOGRAPHY, REVERSE-PHASE; DRUG DELIVERY SYSTEMS; MALEIMIDES; MOLECULAR WEIGHT; POLYETHYLENE GLYCOLS; REPRODUCIBILITY OF RESULTS;

EID: 84862574072     PISSN: 00219673     EISSN: 18733778     Source Type: Journal    
DOI: 10.1016/j.chroma.2012.03.044     Document Type: Article

References (18)

1. Veronese F.M., Pasut G. Drug Discov. Today 2005, 10:1451.
2. Veronese F.M., Mero A. Biodrugs 2008, 22:315.
3. Payne R.W., Murphy B.M., Manning M.C. Pharm. Dev. Technol. 2011, 16:423.
4. Abuchowski A., van Es T., Palczuk N.C., Davis F.F. J. Biol. Chem. 1977, 252:3578.
5. Roberts M.J., Bentley M.D., Harris J.M. Adv. Drug Deliv. Rev. 2002, 54:459.
6. Zalipsky S. Bioconjug. Chem. 1995, 6:150.
7. Huang L., Gough P.C., DeFelippis M.R. Anal. Chem. 2009, 81:567.
8. Kou D., Manius G., Zhan S., Chokshi H.P. J. Chromatogr. A 2009, 1216:5424.
9. Dust J.M., Fang Z., Harris J.M. Macromolecules 1990, 23:3742.
10. Barman B.N., Champion D.H., Sjoberg S.L. J. Chromatogr. A 2009, 1216:6816.
11. Niemczyk H.J., van Arnum S.D. Anal. Chim. Acta 2008, 615:88.
12. van Arnum S.D., Niemczyk H.J., Chang C. J. Pharm. Biomed. Anal. 2008, 50:138.
13. Ananda K., Nacharaju P., Smith P.K., Acharya S.A., Manjula B.N. Anal. Biochem. 2008, 374:231.
14. Abrar S., Trathnigg B. Anal. Bioanal. Chem. 2011, 400:2577.
15. Trathnigg B., Cuong N.V., Ahmed H. J. Sep. Sci. 2009, 32:2857.
16. Khan M.N. J. Pharm. Sci. 1984, 73:1767.
17. Kalia J., Raines R.T. Bioorg. Med. Chem. Lett. 2007, 17:6286.
18. Cho D., Park S., Hong J., Chang T. J. Chromatogr. A 2003, 986:191.