Combined analysis using extended renal reference range of serum free light chain ratio and serum protein electrophoresis improves the diagnostic accuracy of multiple myeloma in renal insufficiency

Clinical Biochemistry

Volumn 45, Issue 10-11, 2012, Pages 740-744

  Park, Jeong Woo ^a   Kim, Yeo Kyeoung ^a   Bae, Eun Hui ^a   Ma, Seong Kwon ^a   Kim, Soo Wan ^a  

^a Chonnam National University Medical School   (South Korea)

Author keywords

Immunoglobulin light chains; Multiple myeloma; Renal insufficiency

Indexed keywords

FREE LIGHT CHAIN PROTEIN; IMMUNOGLOBULIN M; IMMUNOGLOBULIN MM; PLASMA PROTEIN; SYNDECAN 1; UNCLASSIFIED DRUG;

ACUTE KIDNEY FAILURE; ADULT; AGED; ARTICLE; CANCER DIAGNOSIS; CONTROLLED STUDY; DIAGNOSTIC ACCURACY; DIAGNOSTIC TEST ACCURACY STUDY; DIAGNOSTIC VALUE; FEMALE; HUMAN; HUMAN TISSUE; INTERMETHOD COMPARISON; KIDNEY BIOPSY; KIDNEY FAILURE; KIDNEY INJURY; MAJOR CLINICAL STUDY; MALE; MULTIPLE MYELOMA; PLASMA CELL; PREDICTIVE VALUE; PRIORITY JOURNAL; PROTEIN ELECTROPHORESIS; PROTEIN URINE LEVEL; REFERENCE VALUE; RENAL REPLACEMENT THERAPY; RETROSPECTIVE STUDY; SENSITIVITY AND SPECIFICITY;

ADULT; AGED; AGED, 80 AND OVER; BIOLOGICAL MARKERS; BLOOD PROTEIN ELECTROPHORESIS; BLOOD PROTEINS; FEMALE; HUMANS; IMMUNOGLOBULIN KAPPA-CHAINS; IMMUNOGLOBULIN LIGHT CHAINS; KIDNEY; MALE; MIDDLE AGED; MULTIPLE MYELOMA; REFERENCE VALUES; RENAL INSUFFICIENCY; REPRODUCIBILITY OF RESULTS; SENSITIVITY AND SPECIFICITY; YOUNG ADULT;

EID: 84862573600     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2012.03.032     Document Type: Article

References (24)

1. Dimopoulos M.A., Terpos E., Chanan-Khan A., Leung N., Ludwig H., Jagannath S., et al. Renal impairment in patients with multiple myeloma: a consensus statement on behalf of the International Myeloma Working Group. J Clin Oncol 2010, 28:4976-4984. [PubMed: 20956629].
2. Bradwell A.R., Carr-Smith H.D., Mead G.P., Tang L.X., Showell P.J., Drayson M.T., et al. Highly sensitive, automated immunoassay for immunoglobulin free light chains in serum and urine. Clin Chem 2001, 47:673-680. [PubMed: 11274017].
3. Katzmann J.A., Clark R.J., Abraham R.S., Bryant S., Lymp J.F., Bradwell A.R., et al. Serum reference intervals and diagnostic ranges for free kappa and free lambda immunoglobulin light chains: relative sensitivity for detection of monoclonal light chains. Clin Chem 2002, 48:1437-1444.
4. Dispenzieri A., Kyle R., Merlini G., Miguel J.S., Ludwig H., Hajek R., et al. International Myeloma Working Group guidelines for serum-free light chain analysis in multiple myeloma and related disorders. Leukemia 2009, 23:215-224. [PubMed: 19020545].
5. Hill P.G., Forsyth J.M., Rai B., Mayne S. Serum free light chains: an alternative to the urine Bence Jones proteins screening test for monoclonal gammopathies. Clin Chem 2006, 52:1743-1748. [PubMed: 16858075].
6. Katzmann J.A., Dispenzieri A., Kyle R.A., Snyder M.R., Plevak M.F., Larson D.R., et al. Elimination of the need for urine studies in the screening algorithm for monoclonal gammopathies by using serum immunofixation and free light chain assays. Mayo Clin Proc 2006, 81:1575-1578. [PubMed: 17165636].
7. Davids M.S., Murali M.R., Kuter D.J. Serum free light chain analysis. Am J Hematol 2010, 85:787-790. [PubMed: 20721885].
8. Briand P.Y., Decaux O., Caillon H., Grosbois B., Le Treut A., Guenet L. Analytical performance of the serum free light chain assay. Clin Chem Lab Med 2010, 48:73-79. [PubMed: 19929752].
9. Bakker A.J., Bierma-Ram A., Elderman-van der Werf C., Strijdhaftig M.L., van Zanden J.J. Screening for M-proteinemia: serum protein electrophoresis and free light chains compared. Clin Chem Lab Med 2009, 47:1507-1511. [PubMed: 19842994].
10. Wolff F., Thiry C., Willems D. Assessment of the analytical performance and the sensitivity of serum free light chains immunoassay in patients with monoclonal gammopathy. Clin Biochem 2007, 40:351-354. [PubMed: 17239359].
11. Böer K., Deufel T. Quantitation of serum free light chains does not compensate for serum immunofixation only when screening for monoclonal gammopathies. Clin Chem Lab Med 2009, 47:1109-1115. [PubMed: 19728853].
12. Hutchison C.A., Basnayake K., Cockwell P. Serum free light chain assessment in monoclonal gammopathy and kidney disease. Nat Rev Nephrol 2009, 5:621-628. [PubMed: 19786994].
13. Marshall G., Tate J., Mollee P. Borderline high serum free light chain kappa/lambda ratios are seen not only in dialysis patients but also in non-dialysis-dependent renal impairment and inflammatory states. Am J Clin Pathol 2009, 132:309. [PubMed: 19605825].
14. Hutchison C.A., Harding S., Hewins P., Mead G.P., Townsend J., Bradwell A.R., et al. Quantitative assessment of serum and urinary polyclonal free light chains in patients with chronic kidney disease. Clin J Am Soc Nephrol 2008, 3:1684-1690. [PubMed: 18945993].
15. Hutchison C.A., Plant T., Drayson M., Cockwell P., Kountouri M., Basnayake K., et al. Serum free light chain measurement aids the diagnosis of myeloma in patients with severe renal failure. BMC Nephrol 2008, 9:11. [PubMed: 18808676].
16. Abadie J.M., van Hoeven K.H., Wells J.M. Are renal reference intervals required when screening for plasma cell disorders with serum free light chains and serum protein electrophoresis?. Am J Clin Pathol 2009, 131:166-171. [PubMed: 19141376].
17. Diamantidis M.D., Ioannidou-Papagiannaki E., Ntaios G. Novel extended reference range for serum kappa/lambda free light chain ratio in diagnosing monoclonal gammopathies in renal insufficient patients. Clin Biochem 2009, 42:1202-1203. [PubMed: 19375413].
18. International Myeloma Working Group Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 2003, 121:749-757. [PubMed: 12780789].
19. Kyle R.A., Rajkumar S.V. Criteria for diagnosis, staging, risk stratification and response assessment of multiple myeloma. Leukemia 2009, 23:3-9. [PubMed: 18971951].
20. National Kidney Foundation K/DOQI clinical practice guidelines for chronic kidney disease: evaluation, classification, and stratification. Am J Kidney Dis 2002, 39(Suppl. 1):S1-S266. [PubMed: 11904577].
21. Kellum J.A. Defining and classifying AKI: one set of criteria. Nephrol Dial Transplant 2008, 23(5):1471-1472. [PubMed: 18272780].
22. Dimopoulos M.A., Terpos E. Multiple myeloma. Ann Oncol 2010, 21(Suppl. 7):143-150. [PubMed: 20943607].
23. Doyle A., Soutar R., Geddes C.C. Multiple myeloma in chronic kidney disease. Utility of discretionary screening using serum electrophoresis. Nephron Clin Pract 2009, 111:7-11. [PubMed: 19033691].
24. Ma E.S., Lee E.T. A case of IgM paraproteinemia in which serum free light chain values were within reference intervals. Clin Chem 2007, 53:362-363. [PubMed: 17259251].