Diagnosing myocardial infarction by serial measurement of high sensitivity troponin - What type of relative change value (delta) and how much should it be?

Clinical Biochemistry

Volumn 45, Issue 10-11, 2012, Pages 717-718

  Collinson, Paul O ^a  

^a ST GEORGE'S UNIVERSITY OF LONDON   (United Kingdom)

Author keywords

Cardiac troponin i; Cardiac troponin T; Delta change; Relative change value; Troponin

Indexed keywords

TROPONIN; TROPONIN I; TROPONIN T;

DIAGNOSTIC ACCURACY; DIAGNOSTIC VALUE; EDITORIAL; ELECTROCARDIOGRAPHY; HEART INFARCTION; HUMAN; PRIORITY JOURNAL; PROTEIN BLOOD LEVEL; PROTEIN DETERMINATION; SENSITIVITY AND SPECIFICITY;

ACUTE CORONARY SYNDROME; BIOLOGICAL MARKERS; FEMALE; HUMANS; IMMUNOASSAY; MALE; TROPONIN I;

EID: 84862568191     PISSN: 00099120     EISSN: 18732933     Source Type: Journal    
DOI: 10.1016/j.clinbiochem.2012.05.035     Document Type: Editorial

References (20)

1. Wu A.H., Akhigbe P., Wians F. Long-term biological variation in cardiac troponin I. Clin Biochem 2012, 714-716.
2. Apple F.S., Smith S.W., Pearce L.A., et al. Delta changes for optimizing clinical specificity and 60-day risk of adverse events in patients presenting with symptoms suggestive of acute coronary syndrome utilizing the ADVIA Centaur TnI-Ultra assay. Clin Biochem 2012, 711-713.
3. Reichlin T., Hochholzer W., Bassetti S., et al. Early diagnosis of myocardial infarction with sensitive cardiac troponin assays. N Engl J Med 2009, 361:858-867.
4. Keller T., Zeller T., Peetz D., et al. Sensitive troponin I assay in early diagnosis of acute myocardial infarction. N Engl J Med 2009, 361:868-877.
5. Goodacre S.W., Bradburn M., Cross E., et al. The Randomised Assessment of Treatment using Panel Assay of Cardiac Markers (RATPAC) trial: a randomised controlled trial of point-of-care cardiac markers in the emergency department. Heart 2011, 97:190-196.
6. Mills N.L., Churchhouse A.M., Lee K.K., et al. Implementation of a sensitive troponin I assay and risk of recurrent myocardial infarction and death in patients with suspected acute coronary syndrome. JAMA 2011, 305:1210-1216.
7. Collinson P.O., Rosalki S.B., Flather M., et al. Early diagnosis of myocardial infarction by timed sequential enzyme measurements. Ann Clin Biochem 1988, 25(Pt 4):376-382.
8. Thygesen K., Alpert J.S., White H.D., et al. Universal definition of myocardial infarction. Circulation 2007, 116:2634-2653.
9. Eggers K.M., Jaffe A.S., Venge P., et al. Clinical implications of the change of cardiac troponin I levels in patients with acute chest pain - an evaluation with respect to the Universal Definition of Myocardial Infarction. Clin Chim Acta 2011, 412:91-97.
10. Aldous S., Pemberton C., Richards A.M., et al. High-sensitivity troponin T for early rule-out of myocardial infarction in recent onset chest pain. Emerg Med J 2011.
11. Aldous S.J., Richards A.M., Cullen L., et al. Early dynamic change in high-sensitivity cardiac troponin T in the investigation of acute myocardial infarction. Clin Chem 2011, 57:1154-1160.
12. Wu A.H., Lu Q.A., Todd J., et al. Short- and long-term biological variation in cardiac troponin I measured with a high-sensitivity assay: implications for clinical practice. Clin Chem 2009, 55:52-58.
13. Vasile V.C., Saenger A.K., Kroning J.M., et al. Biologic variation of a novel cardiac troponin I assay. Clin Chem 2011, 57:1080-1081.
14. Apple F.S., Collinson P.O. Analytical characteristics of high-sensitivity cardiac troponin assays. Clin Chem 2012, 58:54-61.
15. Apple F.S., Pearce L.A., Smith S.W., et al. Role of monitoring changes in sensitive cardiac troponin I assay results for early diagnosis of myocardial infarction and prediction of risk of adverse events. Clin Chem 2009, 55:930-937.
16. Giannitsis E., Becker M., Kurz K., et al. High-sensitivity cardiac troponin T for early prediction of evolving non-ST-segment elevation myocardial infarction in patients with suspected acute coronary syndrome and negative troponin results on admission. Clin Chem 2010, 56:642-650.
17. Keller T., Zeller T., Ojeda F., et al. Serial changes in highly sensitive troponin I assay and early diagnosis of myocardial infarction. JAMA 2011, 306:2684-2693.
18. Reichlin T., Irfan A., Twerenbold R., et al. Utility of absolute and relative changes in cardiac troponin concentrations in the early diagnosis of acute myocardial infarction. Circulation 2011, 124:136-145.
19. Mueller M., Biener M., Vafaie M., et al. Absolute and relative kinetic changes of high-sensitivity cardiac troponin T in acute coronary syndrome and in patients with increased troponin in the absence of acute coronary syndrome. Clin Chem 2012, 58:209-218.
20. Kavsak P.A., Ko D.T., Wang X., et al. Increasing cardiac troponin changes measured by a research high-sensitivity troponin I assay: absolute vs percentage changes and long-term outcomes in a chest pain cohort. Clin Chem 2010, 56:1902-1904.