Severe vitamin B12 deficiency in an exclusively breastfed 5-month-old Italian infant born to a mother receiving multivitamin supplementation during pregnancy

BMC Pediatrics

Volumn 12, Issue , 2012, Pages

  Guez, Sophie ^a   Chiarelli, Gabriella ^a   Menni, Francesca ^a   Salera, Simona ^a   Principi, Nicola ^a   Esposito, Susanna ^a  

^a UNIVERSITY OF MILAN   (Italy)

Author keywords

Anemia; Iron deficiency; Neurological problems; Vegan diet; Vegan mothers; Vitamin b12 deficiency

Indexed keywords

CYANOCOBALAMIN; FERROUS SULFATE; FOLIC ACID; HEMOGLOBIN; VITAMIN;

ANTHROPOMETRY; ARTICLE; BREAST FEEDING; CASE REPORT; CLINICAL ASSESSMENT; CYANOCOBALAMIN DEFICIENCY; DISEASE SEVERITY; ERYTHROCYTE CONCENTRATE; FEEDING DISORDER; HUMAN; INFANT; IRON DEFICIENCY ANEMIA; IRON THERAPY; ITALY; LATERAL BRAIN VENTRICLE; MALE; MATERNAL NUTRITION; MUSCLE HYPOTONIA; MYELINATION; NEUROIMAGING; NEUROLOGIC DISEASE; NUCLEAR MAGNETIC RESONANCE IMAGING; NUTRITIONAL STATUS; PALLOR; PREGNANCY; SOMNOLENCE; TREATMENT DURATION; VEGETARIAN DIET; VITAMIN SUPPLEMENTATION; DIET SUPPLEMENTATION; FEMALE; PRENATAL CARE;

ANEMIA, IRON-DEFICIENCY; BREAST FEEDING; DIET, VEGETARIAN; DIETARY SUPPLEMENTS; FEMALE; HUMANS; INFANT; ITALY; MALE; PREGNANCY; PRENATAL CARE; PRENATAL NUTRITIONAL PHYSIOLOGICAL PHENOMENA; VITAMIN B 12 DEFICIENCY; VITAMINS;

EID: 84862551904     PISSN: None     EISSN: 14712431     Source Type: Journal    
DOI: 10.1186/1471-2431-12-85     Document Type: Article

References (18)

1. Ludwig ML, Matthews RG. Structure-based perspectives on B12-dependent enzymes. Annu Rev Biochem 1997, 66:269-313. 10.1146/annurev.biochem.66.1.269, 9242908.
2. Stabler SP, Allen RH, Savage DG, Lindenbaum J. Clinical spectrum and diagnosis of cobalamin deficiency. Blood 1990, 76:871-881.
3. Watkins D, Rosenblatt DS. Inborn errors of cobalamin absorption and metabolism. Am J Med Genet C Semin Med Genet 2011, 157:33-44. 10.1002/ajmg.c.30288, 21312325.
4. Van Winckel M, Vande Velde S, De Bruyne R, Van Biervliet S. Clinical practice: vegetarian infant and child nutrition. Eur J Pediatr 2011, 170:1489-1494. 10.1007/s00431-011-1547-x, 21912895.
5. Institute of Medicine Food and Nutrition Board Dietary Reference Intakes: Thiamin, Riboflavin, Niacin, Vitamin B6, Folate, Vitamin B12, Pantothenic Acid, Biotin, and Choline 1998, National Academy Press, Washington, DC, Institute of Medicine Food and Nutrition Board.
6. Lövblad K, Ramelli G, Remonda L, Nirkko AC, Ozdoba C, Schroth G. Retardation of myelination due to dietary vitamin B12 deficiency: cranial MRI findings. Pediatr Radiol 1997, 27:155-158. 10.1007/s002470050090, 9028851.
7. Quentin C, Huybrechts S, Rozen L, De Laet C, Demulder A, Ferster A. Vitamin B12 deficiency in a 9-month-old boy. Eur J Pediatr 2012, 171:193-195. 10.1007/s00431-011-1577-4, 21947220.
8. Baker H, Frank O, Deangelis B, Feingold S, Kaminetzky HA. Role of placenta in maternal-fetal vitamin transfer in humans. Am J Obstet Gynecol 1981, 141:792-796.
9. Specker BL, Black A, Allen L, Morrow F. Vitamin B-12: low milk concentrations are related to low serum concentrations in vegetarian women and to methylmalonic aciduria in their infants. Am J Clin Nutr 1990, 52:1073-1076.
10. Erdeve O, Arsan S, Atasay B, Ileri T, Uysal Z. A breast-fed newborn with megaloblastic anemia-treated with the vitamin B12 supplementation of the mother. J Pediatr Hematol Oncol 2009, 31:763-765. 10.1097/MPH.0b013e3181b7edb5, 20051934.
11. Jones KM, Ramirez-Zea M, Zuleta C, Allen LH. Prevalent vitamin B-12 deficiency in twelve-month-old Guatemalan infants is predicted by maternal B-12 deficiency and infant diet. J Nutr 2007, 137:1307-1313.
12. Katre P, Bhat D, Lubree H, Otiv S, Joshi S, Joglekar C, Rush E, Yajnik C. Vitamin B12 and folic acid supplementation and plasma total homocysteine concentrations in pregnant Indian women with low B12 and high folate status. Asia Pac J Clin Nutr 2010, 19:335-343.
13. Jadhav M, Webb JK, Vaishnava S, Baker SJ. Vitamin B12 deficiency in Indian infants. A clinical syndrome. Lancet 1962, 2:903-907.
14. Thomas MR, Sneed SM, Wei C, Nail PA, Wilson M, Sprinkle EE. The effects of vitamin C, vitamin B6, vitamin B12, folic acid, riboflavin, and thiamin on the breast milk and maternal status of well-nourished women at 6 months postpartum. Am J Clin Nutr 1980, 33:2151-2156.
15. Sneed SM, Zane C, Thomas MR. The effects of ascorbic acid, vitamin B6, vitamin B12, and folic acid supplementation on the breast milk and maternal nutritional status of low socioeconomic lactating women. Am J Clin Nutr 1981, 34:1338-1346.
16. Allen LH. Multiple micronutrients in pregnancy and lactation: an overview. Am J Clin Nutr 2005, 81:1206S-1212S.
17. Dror DK, Allen LH. Effect of vitamin B12 deficiency on neurodevelopment in infants: current knowledge and possible mechanisms. Nutr Rev 2008, 66:250-255. 10.1111/j.1753-4887.2008.00031.x, 18454811.
18. Honzik T, Adamovicova M, Smolka V, Magner M, Hruba E, Zeman J. Clinical presentation and metabolic consequences in 40 breastfed infants with nutritional vitamin B12 deficiency - what have we learned?. Eur J Paediatr Neurol 2010, 14:488-495. 10.1016/j.ejpn.2009.12.003, 20089427.