Methodological issues in detection and typing of serum monoclonal components;Aspetti metodologici nella ricerca e caratterizzazione delle componenti monoclonali nel siero

Biochimica Clinica

Volumn 36, Issue 2, 2012, Pages 84-89

  Dolci, Alberto ^a   Vernocchi, Arialdo ^b  

^a UNIVERSITY OF MILAN   (Italy)

^b IRCCS MULTIMEDICA   (Italy)

Author keywords

[No Author keywords available]

Indexed keywords

AMYLOID PROTEIN; IMMUNOGLOBULIN; IMMUNOGLOBULIN LIGHT CHAIN;

AGAR GEL ELECTROPHORESIS; AMYLOIDOSIS; AUTOANALYSIS; B LYMPHOCYTE; CAPILLARY ZONE ELECTROPHORESIS; CELL CLONE; CLONAL VARIATION; CONCENTRATION (PARAMETERS); IMMUNOASSAY; IMMUNOFIXATION; IMMUNOSUBTRACTION; INTERMETHOD COMPARISON; LIGHT CHAIN; METHODOLOGY; MYELOMA; PROTEIN ANALYSIS; QUANTITATIVE ASSAY; REVIEW; SCREENING TEST; SENSITIVITY AND SPECIFICITY; SERUM PROTEIN ELECTROPHORESIS;

EID: 84862550407     PISSN: 03930564     EISSN: None     Source Type: Journal    
DOI: None     Document Type: Review

References (38)

1. Graziani MS, Dolci A, Greco C, et al per il Gruppo di Studio "Proteine" della SIBioC. Indicazioni per la richiesta di elettroforesi sieroproteica. Biochim Clin 2008;32:48-51.
2. Katzmann JA, Kyle RA, Benson J, et al. Screening panels for detection of monoclonal gammopathies. Clin Chem 2009;55:1517-22.
3. Keren DF. Procedures for the evaluation of monoclonal immunoglobulins. Arch Pathol Lab Med 1999;123:126-32. (Pubitemid 29093597)
4. Jolliff CR, Blessum CR. Comparison of serum protein electrophoresis by agarose gel and capillary zone electrophoresis in a clinical setting. Electrophoresis 1997;18:1781-4. (Pubitemid 27451833)
5. Gay-Bellile C, Bengoufa D, Houze P, et al. Automated multicapillary electrophoresis for analysis of human serum proteins. Clin Chem 2003;49:1909-15. (Pubitemid 37340326)
6. Katzmann JA, Clark R, Sanders E, et al. A. Prospective study of serum protein capillary electrophoresis immunotyping of monoclonal proteins by immunosubtraction. Am J. Clin Pathol 1998;110:503-9. (Pubitemid 28443444)
7. Bossuyt X, Marien G. False-negative results in detection of monoclonal proteins by capillary zone electrophoresis: A prospective study. Clin Chem 2001;47:1477-9. (Pubitemid 32678833)
8. Mariën G, Vranken G, Demuylder M, et al. Clinical capillary zone electrophoresis of serum proteins: balancing high sensitivity and high specificity. Clin Chem 2003;49:1419-20.
9. Bossuyt X. Separation of serum proteins by automated capillary zone electrophoresis. Clin Chem Lab Med 2003;41:762-72. (Pubitemid 36834120)
10. McCudden CR, Mathews SP, Hainsworth SA, et al. Performance comparison of capillary and agarose gel electrophoresis for the identification and characterization of monoclonal immunoglobulins. Am J Clin Pathol 2008;129:451-8. (Pubitemid 352029299)
11. Infusino I, Dolci A, Panteghini M. Confronto tra due sistemi per elettroforesi capillare e in gel d'agarosio per la ricerca e caratterizzazione di componenti monoclonali nel siero. Biochim Clin 2008;32:554-8.
12. Merlini G, Marciano S, Gasparro C, et al. The Pavia approach to clinical protein analysis. Clin Chem Lab Med 2001;39:1025-8. (Pubitemid 33133622)
13. Katzmann JA, Stankowski-Drengler TJ, Kyle RA, et al. Specificity of serum and urine protein electrophoresis for the diagnosis of monoclonal gammophaties. Clin Chem 2010;56:1899-900.
14. Lakshminarayanan R, Li Y, Janatpour K, et al. Detection by immunofixation of M protein in hypogammaglobulinemic patients with normal serum protein electrophoresis results. Am J Clin Pathol 2007;127:746-51.
15. Palladini G, Russo P, Bosoni T, et al. Identification of amyloidogenic light chains requires the combination of serum-free light chain assay with immunofixation of serum and urine. Clin Chem 2009;55:499-504.
16. Righetti G, Graziani MS. Sei casi di gammopatia monoclonale IgD. Biochim Clin 2011;35:417-22.
17. Luraschi P, Infusino I, Zorzoli I et al. Heavy chain disease can be detected by capillary zone electrophoresis. Clin Chem 2005;51;247-9. (Pubitemid 40024049)
18. Mariën G, Verhoef G, Bossuyt X. Detection of heavy chain disease by capillary zone electrophoresis. Clin Chem 2005;51:1302-3.
19. Ognibene A, Graziani MS, Caldini A, et al. Computerassisted detection of monoclonal components: results from the multicenter study for the evaluation of CASPER (Computer Assisted Serum Protein Electrophoresis Recognizer) algorithm. Clin Chem Lab Med 2008;46:1183-8.
20. International Myeloma Working Group. Criteria for the classification of monoclonal gammopathies, multiple myeloma and related disorders: a report of the International Myeloma Working Group. Br J Haematol 2003;121:749-57.
21. Durie BGM, Harousseau JL, Miguelet JS, et al. on behalf of International Myeloma Working Group. International uniform response criteria for multiple myeloma. Leukemia 2006;20:1467-73. (Pubitemid 44264086)
22. Mussap M, Pietrogrande F, Ponchia S, et al. Measurement of serum monoclonal components: comparison between densitometry and capillary zone electrophoresis. Clin Chem Lab Med 2006;44:609-11. (Pubitemid 43735634)
23. Luraschi P, Infusino I, Merlotti C, Franzini C. Analytical variation in the measurement of serum monoclonal component by capillary electrophoresis. Clin Chim Acta 2004;349:151-6. (Pubitemid 39312000)
24. Merlini G. Perché è importante identificare e segnalare le piccole componenti monoclonali. Biochim Clin 2012;36:25-8.
25. Alper CA, Johnson AM. Immunofixation electrophoresis: a technique for the study of protein polymorphism. Vox Sang 1969;17:445-52.
26. Aguzzi F, Poggi N. "Immunosubtraction" electrophoresis: a simple method for identifying specific proteins producing the cellulose acetate electrophoretogram. Boll Ist Sieroter Milan 1977;56:212-6. (Pubitemid 8175537)
27. Bossuyt X, Mariën G. Detection of monoclonal proteins by capillary zone electrophoresis: comparison of 2 multichannel automated systems. Clin Chem 2007;53:152-3. (Pubitemid 46047784)
28. Pateri F, Dolci A. L'elettroforesi capillare è più sensibile dell'immunofissazione nel rilevare componenti monoclonali IgG. Biochim Clin 2005;29:224.
29. Bienvenu J, Graziani MS, Arpin F, et al. Multicenter evaluation of the Paragon CZE 2000 capillary zone electrophoresis system for serum protein electrophoresis and monoclonal component typing. Clin Chem 1998;44:599-605. (Pubitemid 28141358)
30. Keularts IM, Beunis MH, van Oord J, et al. Detection and identification of low-concentration M proteins with CZE/IS; a 'dry' analysis. Ann Clin Biochem 2005,42:133-5. (Pubitemid 40520507)
31. Harke L, Chan C, Bhagavan NV, et al. A healthy young man presenting with multiple rib fractures. Clin Chem 2010;56:1390-3.
32. Dolci A, Infusino I, Mozzi R, et al. Indicazioni per il corretto impiego delle indagini biochimiche nelle gammopatie monoclonali con particolare riferimento alla determinazione delle catene leggere libere delle immunoglobuline nel siero. Biochim Clin 2008;32:564-8.
33. Albertini R, Merlini G. La misura delle catene leggere libere delle immunoglobuline nel siero: aspetti analitici e clinici. Biochim Clin 2010;34:26-9.
34. Bradwell AR, Carr-Smith HD, Mead GP, et al. Highly sensitive, automated immunoassay for immunoglobulin free light chains in serum and urine. Clin Chem 2001;47:673-80. (Pubitemid 32275810)
35. Tate JR, Bazeley S, Sykes S, et al. Quantitative serum free light-chain assay - analytical issues. Clin Biochem Rev 2009;30:131-40.
36. Dispenzieri A, Kyle R, Merlini G. et al. International Myeloma Working Group guidelines for serum-free light chains analysis in multiple myeloma and related disorders. Leukemia 2009;23:215-24.
37. Kyle RA, Durie BG, Rajkumar SV, et al. for the International Myeloma Working Group. Monoclonal gammopathy of undetermined significance (MGUS) and smoldering (asymptomatic) multiple myeloma: IMWG consensus perspectives risk factors for progression and guidelines for monitoring and management. Leukemia 2010;24:1121-7.
38. Te Velthuis H, Knop I, Stam P, et al. N Latex FLC - new monoclonal high-performance assays for the determination of free light chain kappa and lambda. Clin Chem Lab Med 2011;49:1323-32.