Factors associated with indeterminate and false negative results of quantiFERON-TB gold in-tube test in active tuberculosis

Tuberculosis and Respiratory Diseases

Volumn 72, Issue 5, 2012, Pages 416-425

  Cho, Kiwon ^a   Cho, Eunha ^a   Kwon, Soohoon ^a   Im, Sanghyuk ^a   Sohn, In ^a   Song, Sookhee ^a   Kim, Hyeok ^a   Kim, Suhyun ^a  

^a Seoul Medical Center   (South Korea)

Author keywords

Aged; Interferon gamma release tests; Tuberculin test

Indexed keywords

C REACTIVE PROTEIN;

ADULT; AGE DISTRIBUTION; AGED; ARTICLE; CD4 LYMPHOCYTE COUNT; CONTROLLED STUDY; DIAGNOSTIC TEST; FALSE NEGATIVE RESULT; FEMALE; HUMAN; INTENSIVE CARE UNIT; LUNG TUBERCULOSIS; LYMPHOCYTOPENIA; MAJOR CLINICAL STUDY; MALE; QUANTIFERON TB GOLD IN TUBE TEST;

EID: 84862540488     PISSN: 17383536     EISSN: None     Source Type: Journal    
DOI: 10.4046/trd.2012.72.5.416     Document Type: Article

References (20)

1. Sester M, Sotgiu G, Lange C, Giehl C, Girardi E, Migliori GB, et al. Interferon-gamma release assays for the diagnosis of active tuberculosis: a systematic review and meta-analysis. Eur Respir J 2011;37:100-11.
2. Lee HW, Park HY, Ann YM, Sohn KC. Clinical significance of interferon gamma release assay for diagnosis of tuberculosis in children. Korean J Pediatr Infect Dis 2010;17:137-47.
3. Mazurek GH, Jereb J, Lobue P, Iademarco MF, Metchock B, Vernon A, et al. Guidelines for using the QuantiFERON-TB Gold test for detecting Mycobacterium tuberculoids infection, United States. MMWR Recomm Rep 2005;54:49-55.
4. Mazurek GH, Jereb J, Vernon A, LoBue P, Goldberg S, Castro K, et al. Updated guidelines for using interferon gamma release assays to detect Mycobacterium tuberculosis infection - United States, 2010. MMWR Recomm Rep 2010;59:1-25.
5. Kobashi Y, Sugiu T, Mouri K, Obase Y, Miyashita N, Oka M. Indeterminate results of QuantiFERON TB-2G test performed in routine clinical practice. Eur Respir J 2009;33:812-5.
6. Wang CS, Chen HC, Yang CJ, Wang WY, Chong IW, Hwang JJ, et al. The impact of age on the demographic, clinical, radiographic characteristics and treatment outcomes of pulmonary tuberculosis patients in Taiwan. Infection 2008;36:335-40.
7. Kobashi Y, Mouri K, Miyashita N, Okimoto N, Matsushima T, Kageoka T, et al. QuantiFERON TB-2G test for patients with active tuberculosis stratified by age groups. Scand J Infect Dis 2009;41:841-6.
8. Kang YA, Lee HW, Hwang SS, Um SW, Han SK, Shim YS, et al. Usefulness of whole-blood interferon-gamma assay and interferon-gamma enzyme-linked immunospot assay in the diagnosis of active pulmonary tuberculosis. Chest 2007;132:959-65.
9. Shin JY, Jung SY, Lee JE, Park JW, Yoo SJ, Park HS, et al. Characteristics of pulmonary tuberculosis in elderly people. Tuberc Respir Dis 2010;69:163-70.
10. Patel YR, Mehta JB, Harvill L, Gateley K. Flexible bronchoscopy as a diagnostic tool in the evaluation of pulmonary tuberculosis in an elderly population. J Am Geriatr Soc 1993;41:629-32.
11. Park SY, Jeon K, Um SW, Kwon OJ, Kang ES, Koh WJ. Clinical utility of the QuantiFERON-TB Gold In-Tube test for the diagnosis of active pulmonary tuberculosis. Scand J Infect Dis 2009;41:818-22.
12. Park SY, Park YB, Choi JH, Lee JY, Kim JS, Mo EK. The diagnostic value of interferon-gamma assay in patients with active tuberculosis. Tuberc Respir Dis 2009;66:13-9.
13. Miranda C, Yen-Lieberman B, Terpeluk P, Tomford JW, Gordon S. Reducing the rates of indeterminate results of the QuantiFERON-TB Gold In-Tube test during routine preemployment screening for latent tuberculosis infection among healthcare personnel. Infect Control Hosp Epidemiol 2009;30:296-8.
14. Ferrara G, Losi M, Meacci M, Meccugni B, Piro R, Roversi P, et al. Routine hospital use of a new commercial whole blood interferon-gamma assay for the diagnosis of tuberculosis infection. Am J Respir Crit Care Med 2005;172:631-5.
15. Kobashi Y, Mouri K, Yagi S, Obase Y, Miyashita N, Okimoto N, et al. Clinical utility of the QuantiFERON TB-2G test for elderly patients with active tuberculosis. Chest 2008;133:1196-202.
16. Kobashi Y, Fukuda M, Yoshida K, Oka M. An indeterminate QuantiFERON TB-2G response for miliary tuberculosis, due to severe pancytopenia. J Infect Chemother 2007;13:414-7.
17. Kobashi Y, Mouri K, Obase Y, Fukuda M, Miyashita N, Oka M. Clinical evaluation of QuantiFERON TB-2G test for immunocompromised patients. Eur Respir J 2007;30:945-50.
18. Kobashi Y, Mouri K, Yagi S, Obase Y, Fukuda M, Miyashita N, et al. Usefulness of the QuantiFERON TB-2G test for the differential diagnosis of pulmonary tuberculosis. Intern Med 2008;47:237-43.
19. Kim EY, Lim JE, Jung JY, Son JY, Lee KJ, Yoon YW, et al. Performance of the tuberculin skin test and interferon-gamma release assay for detection of tuberculosis infection in immunocompromised patients in a BCG-vaccinated population. BMC Infect Dis 2009;9:207.
20. Kim YY, Lee J, Lee YJ, Lee SY, Lee YH, Choi KJ, et al. Sensitivity of whole-blood interferon-gamma release assay according to the severity and the location of disease in patients with active tuberculosis. Tuberc Respir Dis 2011;70:125-31.