Changes in expression of vascular endothelial growth factor and its receptors in the aging mouse cochlea, part 1: The normal-hearing mouse

Journal of Otolaryngology - Head and Neck Surgery

Volumn 41, Issue SUPPL. 1, 2012, Pages

  Kandasamy, Thileeban ^a   Clinkard, David J ^b   Qian, Wei ^b   Chen, Stephen ^b   Chen, Joseph M ^b   Harrison, Robert V ^b   Lin, Vincent Y W ^b  

^a UNIVERSITY OF TORONTO   (Canada)

^b HOSPITAL FOR SICK CHILDREN   (Canada)

Author keywords

Angiogenesis; Presbycusis; Vascular endothelial growth factor

Indexed keywords

VASCULOTROPIN; VASCULOTROPIN RECEPTOR 1; VASCULOTROPIN RECEPTOR 2;

AGING; ANIMAL EXPERIMENT; ANIMAL TISSUE; ARTICLE; AUDITORY THRESHOLD; COCHLEA; CONTROLLED STUDY; EVOKED BRAIN STEM AUDITORY RESPONSE; GROUPS BY AGE; HEARING ACUITY; HISTOLOGY; IMMUNOHISTOCHEMISTRY; NONHUMAN; PRIORITY JOURNAL; PROTEIN EXPRESSION; REAL TIME POLYMERASE CHAIN REACTION; SPIRAL GANGLION; STRIA VASCULARIS; VASCULARIZATION;

AGING; ANIMALS; COCHLEA; GENE EXPRESSION REGULATION, DEVELOPMENTAL; HEARING; IMMUNOHISTOCHEMISTRY; MICE; NEOVASCULARIZATION, PHYSIOLOGIC; REAL-TIME POLYMERASE CHAIN REACTION; RNA, MESSENGER; VASCULAR ENDOTHELIAL GROWTH FACTOR A; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-1; VASCULAR ENDOTHELIAL GROWTH FACTOR RECEPTOR-2;

EID: 84862524120     PISSN: 19160216     EISSN: None     Source Type: Journal    
DOI: 10.2310/7070.2011.110091     Document Type: Article

References (16)

1. Davis A, Stephens D, Rayment A, Thomas K. Hearing impairments in middle age: the acceptability, benefit and cost of detection (ABCD). Br J Audiol 1997;26:1-14, doi:10.3109/03005369209077866.
2. Mulrow CD, Lichtenstein MJ. Screening for hearing impairment in the elderly: rationale and strategy. J Gen Intern Med 1991;6:249-58, doi:10.1007/BF02598971.
3. Schuknecht HF. Further observations on the pathology of presbycusis. Arch Otolaryngol 1964;80:369-82, doi:10.1001/archotol.1964.00750040381003.
4. Schuknecht HF, Gacek MR. Cochlear pathology in presbycusis. Ann Otol Rhinol Laryngol 1993;102:1-16. (Pubitemid 23025887)
5. Saitoh Y, Hosokawa M, Shimada A, et al. Age-related cochlear degeneration in senescence-accelerated mouse. Neurobiol Aging 1995;16:129-36, doi:10.1016/0197-4580(94)00153-7.
6. Gratton MA, Schmiedt RA, Schulte BA. Age-related decreases in endocochlear potential are associated with vascular abnormalities in the stria vascularis. Hear Res 1996;102:181-90, doi:10.1016/S0378-5955(96)90017-9.
7. Thomopoulos GN, Spicer SS, Gratton MA, Schulte BA. Age-related thickening of basement membrane in stria vascularis capillaries. Hear Res 1997;111:31-41, doi:10.1016/S0378-5955(97)00080-4. (Pubitemid 27395938)
8. Breen EC. VEGF in biological control. J Cell Biochem 2007;1-2:1358-67, doi:10.1002/jcb.21579. (Pubitemid 350223939)
9. Picciotti PM, Torsello A, Cantore I, et al. Expression of vascular endothelial growth factor and its receptors in the cochlea of various experimental animals. Acta Otolaryngol (Stockh) 2005;125:1152-7, doi:10.1080/00016480510044241. (Pubitemid 41800866)
10. Michel O, Hess A, Bloch W, et al. Immunohistochemical detection of vascular endothelial growth factor (VEGF) and VEGF receptors Flt-1 and KDR/Flk-1 in the cochlea of guinea pigs. Hear Res 2001;155:175-80, doi:10.1016/S0378- 5955(01)00262-3. (Pubitemid 32401599)
11. Picciotti PM, Fetoni AR, Paludetti G, et al. Vascular endothelial growth factor (VEGF) expression in noise-induced hearing loss. Hear Res 2006;214:76-83, doi:10.1016/j.heares.2006.02.004.
12. Selivanova O, Heinrich UR, Brieger J, et al. Fast alterations of vascular endothelial growth factor (VEGF) expression and that of its receptors (Flt-1, Flk-1 and neuropilin) in the cochlea of guinea pigs after moderate noise exposure. Eur Arch Otorhinolaryngol 2007;264:121-8, doi:10.1007/s00405-006-0154- 3. (Pubitemid 46011292)
13. Shi X. Cochlear pericyte responses to acoustic trauma and the involvement of hypoxia-inducible factor-1alpha and vascular endothelial growth factor. Am J Pathol 2009;174:1692-704, doi:10.2353/ajpath.2009.080739.
14. Picciotti P, Torsello A, Wolf FI, et al. Age-dependent modifications of expression level of VEGF and its receptors in the inner ear. Exp Gerontol 2004;39:1253-8, doi:10.1016/j.exger.2004.06.003. (Pubitemid 39024375)
15. Schmittgen T, Livak K. Analyzing real-time PCR data by the comparative CT method. Nat Protoc 2008;3:1101-8, doi:10.1038/nprot.2008.73. (Pubitemid 351818697)
16. Zheng QY, Johnson KR, Erway LC. Assessment of hearing in 80 inbred strains of mice by ABR threshold analyses. Hear Res 1999;130:94-107, doi:10.1016/S0378-5955(99)00003-9. (Pubitemid 29172586)